Cerebrospinal fluid hydrocephalus shunting: cisterna magna, ventricular frontal, ventricular occipital

Gholampour, Seifollah; Patel, Jay; Yamini, Bakhtiar; Frim, David M.

doi:10.1007/s10143-022-01798-0

Cited by 10 publications

(5 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly even 15 months after shunting and after disappearing all clinical signs and symptoms of hydrocephalus, except for the brain volume, other parameters did not return to the normal range. Previous studies showed that the most common reasons for shunt failure are obstruction, infection, and overdrainage 61 . In some patients, signs, symptoms, and pain will return after shunting and this leads to an unsuccessful shunting.…”

Section: Discussionmentioning

confidence: 99%

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Gholampour

Frim²,

Yamini³

2022

Commun Biol

Self Cite

View full text Add to dashboard Cite

The unpredictable complexities in hydrocephalus shunt outcomes may be related to the recovery behavior of brain tissue after shunting. The simulated cerebrospinal fluid (CSF) velocity and intracranial pressure (ICP) over 15 months after shunting were validated by experimental data. The mean strain and creep of the brain had notable changes after shunting and their trends were monotonic. The highest stiffness of the hydrocephalic brain was in the first consolidation phase (between pre-shunting to 1 month after shunting). The viscous component overcame and damped the input load in the third consolidation phase (after the fifteenth month) and changes in brain volume were stopped. The long-intracranial elastance (long-IE) changed oscillatory after shunting and there was not a linear relationship between long-IE and ICP. We showed the long-term effect of the viscous component on brain recovery behavior of hydrocephalic brain. The results shed light on the brain recovery mechanism after shunting and the mechanisms for shunt failure.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Gholampour

Frim²,

Yamini³

2022

Commun Biol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enlarged ventricles are often associated with elevated intracranial pressure (ICP), but the pressure can often be within the normal range as in normal-pressure hydrocephalus (NPH), especially in older individuals 38 . Treatments for hydrocephalus include invasive neurosurgeries that create a new drainage route for the fluid, but these dramatic procedures can result in postsurgical complications 39 . Ventriculomegaly is another neurological disease characterized by ventricular enlargement with excessive CSF accumulation 40 .…”

Section: Mainmentioning

confidence: 99%

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation

Choi,

Park,

Choi

et al. 2024

Nat Neurosci

View full text Add to dashboard Cite

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment with the chemical agonist Yoda1 is sufficient to increase cerebrospinal fluid (CSF) outflow by improving lymphatic absorption and transport. The abnormal accumulation of CSF, which often leads to hydrocephalus and ventriculomegaly, currently lacks effective treatments. We discovered that meningeal lymphatics in mouse models of Down syndrome were incompletely developed and abnormally formed. Selective overexpression of Piezo1 in lymphatics or systemic administration of Yoda1 in mice with hydrocephalus or Down syndrome resulted in a notable decrease in pathological CSF accumulation, ventricular enlargement and other associated disease symptoms. Together, our study highlights the importance of Piezo1-mediated lymphatic mechanotransduction in maintaining brain fluid drainage and identifies Piezo1 as a promising therapeutic target for treating excessive CSF accumulation and ventricular enlargement.

show abstract

“…Previous studies have attempted to consider the impact of various variables to reduce shunt failure and improve shunt outcomes. In this context, we evaluated the effect of different catheter routes on the risk of shunt failure ( Gholampour et al, 2022b ). Additionally, several studies have examined the impact of valve characteristics on shunt efficacy.…”

Section: Introductionmentioning

confidence: 99%

Optimization of number and range of shunt valve performance levels in infant hydrocephalus: a machine learning analysis

Waterstraat,

Dehghan,

Gholampour

2024

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Shunt surgery is the main treatment modality for hydrocephalus, the leading cause of brain surgery in children. The efficacy of shunt surgery, particularly in infant hydrocephalus, continues to present serious challenges in achieving improved outcomes. The crucial role of correct adjustments of valve performance levels in shunt outcomes has been underscored. However, there are discrepancies in the performance levels of valves from different companies. This study aims to address this concern by optimizing both the number and range of valve performance levels for infant hydrocephalus, aiming for improved shunt surgery outcomes. We conducted a single-center cohort study encompassing infant hydrocephalus cases that underwent initial shunt surgery without subsequent failure or unimproved outcomes. An unsupervised hierarchical machine learning method was utilized for clustering and reporting the valve drainage pressure values for all patients within each identified cluster. The optimal number of clusters corresponds to the number of valve performance levels, with the valve drainage pressure ranges within each cluster indicating the pressure range for each performance level. Comparisons based on the Silhouette coefficient between 3-7 clusters revealed that this coefficient for the 4-cluster (4-performance level) was at least 28.3% higher than that of other cluster formations in terms of intra-cluster similarity. The Davies-Bouldin index for the 4-performance level was at least 37.2% lower than that of other configurations in terms of inter-cluster dissimilarity. Cluster stability, indicated by a Jaccard index of 71% for the 4-performance level valve, validated the robustness, reliability, and repeatability of our findings. Our suggested optimized drainage pressure ranges for each performance level (1.5–5.0, 5.0–9.0, 9.0–15.0, and 15.0–18.0 cm H2O) may potentially assist neurosurgeons in improving clinical outcomes for patients with shunted infantile hydrocephalus.

show abstract

Cerebrospinal fluid hydrocephalus shunting: cisterna magna, ventricular frontal, ventricular occipital

Cited by 10 publications

References 72 publications

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation

Optimization of number and range of shunt valve performance levels in infant hydrocephalus: a machine learning analysis

Contact Info

Product

Resources

About