2017
DOI: 10.1186/s12936-017-1954-1
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Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Abstract: BackgroundOne-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunction in other CNS infections. In the present study, the association between the kynurenine pathway and neurologic/cognitive complications in children with CM was investigated.MethodsCerebrospinal fluid (CSF) concentra… Show more

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Cited by 36 publications
(36 citation statements)
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“…The anthranilic acid (6) has intensive blue fluorescence [31], which can overlap with the red [33,36] our synthesized nano-system is potentially suitable for a rapid detection of Kyn. The dynamic range was appointed between 15-100 μM (Fig.…”
Section: (Here Figure 3)mentioning
confidence: 99%
“…The anthranilic acid (6) has intensive blue fluorescence [31], which can overlap with the red [33,36] our synthesized nano-system is potentially suitable for a rapid detection of Kyn. The dynamic range was appointed between 15-100 μM (Fig.…”
Section: (Here Figure 3)mentioning
confidence: 99%
“…The content of KYN estimated by means of paper chromatography and fluorescence spectral analysis is 1 nmol/mL in human aqueous humor and 10–100 nmol/g in lenses [25]. In comparison, the concentration of KYN in human cerebrospinal fluid is 134.5 nM [26] and in serum 1.8 μM [27, 28]. A topical application of KYN is considered to be safe [7].…”
Section: Discussionmentioning
confidence: 99%
“…Kynurenine pathway Inhibition of quinolinic and picolinic acids CM [96][97][98] Trends in Parasitology transporter A1 (ABCA1) is a key molecule modulating the formation of microparticles. ABCA1 regulates the movement of PS from the inner to the outer leaflet.…”
Section: Microparticles and The Kynurenine Pathway As Regulators Of Tmentioning
confidence: 99%
“…One such pathway implicated in the BBB dysfunction is the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan. Studies on malaria patients have revealed an increase in levels of kynurenine and kynurenine metabolitesquinolinic acid, kynurenic acid, and picolinic acidin the cerebrospinal fluid [96][97][98]. The levels of quinolinic and picolinic acids correlated with the severity of the disease [97].…”
Section: Microparticles and The Kynurenine Pathway As Regulators Of Tmentioning
confidence: 99%