2021
DOI: 10.1002/cti2.1318
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Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Abstract: The high morbidity and mortality of neuroinflammatory diseases drives significant interest in understanding the underlying mechanisms involved in the innate and adaptive immune response of the central nervous system (CNS). Diagnostic biomarkers are important to define treatable neuroinflammation. Metabolomics is a rapidly evolving research area offering novel insights into metabolic pathways, and elucidation of reliable metabolites as biomarkers for diseases. This review focuses on the emerging literature rega… Show more

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Cited by 36 publications
(43 citation statements)
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“…Up to now, there is still no clarity regarding the pathogenesis and how RANBP2 promotes the development of ANE. Early biomarkers for ANE are still under investigation, but CSF neopterin is one of those being looked at ( 34 , 35 ). Treatment evidence is limited to case reports and case series data.…”
Section: Para- and Post-infectious Neurological Disordersmentioning
confidence: 99%
“…Up to now, there is still no clarity regarding the pathogenesis and how RANBP2 promotes the development of ANE. Early biomarkers for ANE are still under investigation, but CSF neopterin is one of those being looked at ( 34 , 35 ). Treatment evidence is limited to case reports and case series data.…”
Section: Para- and Post-infectious Neurological Disordersmentioning
confidence: 99%
“…Investigations based on metabolomics may have a role in distinguishing neuroinflammation from infection [57]. Of particular interest are lipid-based biomarkers, such as free phosphatidyl choline levels [58,59].…”
Section: Csf Features Of Infectionmentioning
confidence: 99%
“…Metabolite analysis and interpretation of CSF is fundamental to understanding the mechanisms of neuroinflammation, enabling biomarker discovery and disease diagnosis, and suggesting therapeutic directions. There are many challenges, however, to obtaining CSF normal controls from healthy individuals, owing to ethical issues and the invasive nature of the matrix [64]. Unlike CSF, biological samples such as blood and urine can be obtained non-invasively and safely, and various metabolic changes can be observed.…”
Section: Biomarkers Of Multiple Sclerosis (Mus)mentioning
confidence: 99%
“…Still, most of these are related to general inflammatory responses and cannot be used as clinical diagnostic indicators [65]. Therefore, the study of CSF metabolomics is essential to discover biomarkers for multiple sclerosis [64].…”
Section: Biomarkers Of Multiple Sclerosis (Mus)mentioning
confidence: 99%