Cerebrospinal fluid neurofilament tracks fMRI correlates of attention at the first attack of multiple sclerosis

Tortorella, Carla; Direnzo, Vita; Taurisano, Paolo; Romano, Raffaella; Ruggieri, Maddalena; Zoccolella, Stefano; Mastrapasqua, Mariangela; Popolizio, Teresa; Blasi, Giuseppe; Bertolino, Alessandro; Trojano, María

doi:10.1177/1352458514546789

Cited by 21 publications

(18 citation statements)

References 27 publications

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“…The results presented here indicate an association of both CSF CHI3L1 and NF‐L levels with clinical parameters (EDSS score and number of relapses, respectively) in our cohort of patients. CHI3L1 has been previously related to long‐term cognitive impairment , whereas NF‐L correlated with attention using functional magnetic resonance imaging . The present study underpins these previous data, revealing that levels of CHI3L1 and NF‐L correlate in the early stages of MS with worse performance on Trail Making Test A and WLG, respectively, indicating a decrease in attention and information‐processing speed as well as alterations in executive functions.…”

Section: Discussionsupporting

confidence: 80%

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain

Quintana

Coll

Salavedra-Pont

et al. 2018

Euro J of Neurology

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Section: Discussionsupporting

confidence: 80%

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain

Quintana

Coll

Salavedra-Pont

et al. 2018

Euro J of Neurology

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“…CSF NF-L has also been shown to increase in axonal degenerative disease such as Alzheimer’s disease (AD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)83435363738. Thus, measurement of NF-L in serum may have utility in the clinical and research settings for these axonal degenerative diseases, where currently biomarker-supported diagnosis and are limited to analyses of CSF.…”

Section: Discussionmentioning

confidence: 99%

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Shahim

Gren

Liman

et al. 2016

Sci Rep

304

271

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Axonal white matter injury is believed to be a major determinant of adverse outcomes following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament light protein (NF-L), a protein found in long white-matter axons, in blood samples, may serve as a suitable biomarker for neuronal damage in TBI patients. To test our hypotheses, we designed a study in two parts: i) we developed an immunoassay based on Single molecule array technology for quantification of NF-L in blood, and ii) in a proof-of-concept study, we tested our newly developed method on serial serum samples from severe TBI (sTBI) patients (n = 72) and controls (n = 35). We also compared the diagnostic and prognostic utility of NF-L with the established blood biomarker S100B. NF-L levels were markedly increased in sTBI patients compared with controls. NF-L at admission yielded an AUC of 0.99 to detect TBI versus controls (AUC 0.96 for S100B), and increased to 1.00 at day 12 (0.65 for S100B). Importantly, initial NF-L levels predicted poor 12-month clinical outcome. In contrast, S100B was not related to outcome. Taken together, our data suggests that measurement of serum NF-L may be useful to assess the severity of neuronal injury following sTBI.

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“…Here, we provide evidence that the duration of the TUG is associated with the severity of neuroaxonal injury quantified by sNfL. 4 CSF NFL levels have been associated with attentional control in patients with MS. 9 Also, attentional performances are associated with the duration of the TUG in older adults and in patients with MS, 2 in addition to its strong association with the EDSS score and gait disability. 1 The multimodality of the TUG that integrates several components of both gait and cognitive parameters may explain why the TUG is the only one measure (among spatiotemporal gait parameters and cognitive performances) that was associated with sNfL in our study.…”

Section: Discussionmentioning

confidence: 99%

Serum neurofilament light chains in MS

Allali

Kuhle

Bréville

et al. 2020

Neurol Neuroimmunol Neuroinflamm

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ObjectiveThis cross-sectional study aims to assess the association between neuroaxonal damage assessed by serum neurofilament light chain (sNfL) and the Timed Up and Go (TUG)—a reliable and rapid measure of global neurologic disability—in patients with MS.MethodsA total of 41 consecutive patients with MS (38.0 ± 10.4 years; 57% women) with low level of disability (Expanded Disability Status Scale [EDSS] score 0–3) (EDSS score 1.0, interquartile range [IQR] 0.0–2.0) were included in this study. The TUG and sNfL were measured in a 6-month interval, together with a comprehensive neuropsychological and quantitative gait evaluation. The association of sNfL (dependant variable) with TUG, and other gait, cognitive, and behavioral measures (independent variables) were evaluated with multiple linear regressions adjusted for age, sex, and EDSS score.ResultsThe sNfL concentration was 23.51 pg/mL (IQR 16.51–32.21 pg/mL), and the mean TUG was 9.27 ± 1.70 seconds. Only the TUG was associated with sNfL (β = 0.021; 95% CI 0.003–0.037; p = 0.022) (after adjusting for age, sex, and EDSS score), whereas this was not the case for gait and neuropsychological measures.ConclusionsThe TUG—an easy and unexpansive measure of disability—is associated with the degree of neuroaxonal damage, as measured by sNfL, in patients with MS with low level of disability. These findings confirm the validity of the TUG as a reliable bedside measure of global neurologic disability as a result of neuroaxonal damage.

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Cerebrospinal fluid neurofilament tracks fMRI correlates of attention at the first attack of multiple sclerosis

Abstract: Our findings suggest a relationship between CSF NFL levels and load-dependent failure of putaminal recruitment pattern during sustained attention in CIS and suggest a role of CSF NFL as a marker of subclinical abnormality of cognitive pathway recruitment in CIS.

Cited by 21 publications

References 27 publications

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Serum neurofilament light chains in MS

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