Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm

Abstract

Acute increased concentrations of PTX3 in CSF but not in plasma are related to the occurrence of vasospasm, indicating that measurement of CSF PTX3 associated with the clinical evaluation can improve early diagnosis of this complication.

Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals

“…In this context, Zanier [49] investigated the concentrations of PTX3 and its relation with SCV in the plasma and cerebrospinal fluid (CSF) of 38 aSAH patients. PTX3 was elevated in all SAH patients in both plasma and CSF.…”

Ficolin-3–mediated lectin complement pathway activation in patients with subarachnoid hemorrhage

“…Several studies have demonstrated a complementmediated inflammatory response in patients with SAH 16,30,31 ; however, a specific role of LCP has never been shown. A significant relationship between CRP levels and outcome (favorable 6,532 vs unfavorable 7,892 ng/mL, p , 0.01) was observed.…”

“…Clinical management was performed as previously described 16,17 according to international guidelines. A cohort of 39 consecutive patients admitted to the neuro-critical care unit (intensive care unit) with a diagnosis of SAH were prospectively enrolled between 2009 and 2012.…”

“…Early cerebral ischemia was defined as a new hypodense lesion that was visible on the CT performed within the first 3 days post-SAH and delayed cerebral ischemia (DCI) as the appearance of a new hypodense area in one or more arterial-dependent territories detectable on the 21to 28-day follow-up CT. 16 Two investigators blinded to the clinical history independently assessed the occurrence of CT brain ischemia. Early cerebral ischemia was defined as a new hypodense lesion that was visible on the CT performed within the first 3 days post-SAH and delayed cerebral ischemia (DCI) as the appearance of a new hypodense area in one or more arterial-dependent territories detectable on the 21to 28-day follow-up CT. 16 Two investigators blinded to the clinical history independently assessed the occurrence of CT brain ischemia.…”

Diagnostic Value of Pentraxin-3 in Patients with Spontaneous Subarachnoid and Intracerebral Hemorrhage

“…In their study, Ryu et al (20) detected that for ischemic stroke patients, the level of PTX3 at the time of presentation is higher in deceased patients compared to living patients. Zanier et al (21) showed that the level of PTX3 reached its highest in plasma and cerebrospinal fluid (CSF) samples in SAH patients during first 48 hours and during development of vasospasm. In our study, it was detected that the levels of PTX3 at the twelfth hour after presentation were statistically and significantly higher in deceased patients compared to living patients of the SAH group (p<0.05).…”