Cerebrospinal fluid volume in neonates undergoing spinal anaesthesia: a descriptive magnetic resonance imaging study

Rochette, A.; Rancourt, M.-P. Malenfant; Sola, Chrystelle; Prodhomme, O.; Saguintaah, M.; Schaub, Roxane; Molinari, Noelle Angelique M.; Capdevila, Xavier; Dadure, Christophe

doi:10.1093/bja/aew185

Cited by 22 publications

(34 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, spinal CSF volume was not as large as previously reported in neonates . Rochette et al also reported that the spinal CSF volume, from the first thoracic vertebra to the caudal end, was 1.97 (0.54) mL/kg in preterm and term neonates, which was similar to the present study. The spinal CSF volume reported by Rochette et al and the present study are half of the previously reported CSF volumes…”

Section: Discussionsupporting

confidence: 90%

“…This study has extended previous work on CSF analyses in neonates and children younger than 3 years of age to also include older children. Therefore, it is the first study that describes the developmental change in CSF volumes and their relationships with age, height, and weight across broad pediatric age groups, from neonates and infants to adolescents.…”

Section: Discussionmentioning

confidence: 72%

“…First, the CSF volumes were calculated by measuring the areas of spinal cord and dural sac and the heights of MR images. Although this method was used in previous studies, calculated CSF volumes may be different from actual CSF volumes because of this indirect measurement. However, we measured the spinal cord and dural sac areas using multiple vertices in both T1 and T2 images to improve accuracy compared to a previous study .…”

Section: Discussionmentioning

confidence: 99%

“…Although this method was used in previous studies, calculated CSF volumes may be different from actual CSF volumes because of this indirect measurement. However, we measured the spinal cord and dural sac areas using multiple vertices in both T1 and T2 images to improve accuracy compared to a previous study . Second, this is purely an observational report in which the findings may not necessarily translate into clinical care (ie, dosing of local anesthetics for intrathecal blocks in pediatric patients).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Rochette et al used magnetic resonance imaging (MRI) to show that the CSF volume from T1 to S5 in neonates can be estimated as 2 mL/kg in both preterm and term neonates. Forestier et al also used MRI to show the relationships between spinal CSF volume and age, as well as height and weight in patients under 3 years of age.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Lumbosacral and thoracolumbosacral cerebrospinal fluid volume changes in neonates, infants, children, and adolescents: A retrospective magnetic resonance imaging study

Jang

Lee

Seo

et al. 2018

Pediatric Anesthesia

View full text Add to dashboard Cite

Summary Background The volume of cerebrospinal fluid can affect the pharmacokinetics and pharmacodynamics of local anesthetics for spinal anesthesia and other intrathecal medications. Aims The objective of this study was to estimate the lumbosacral cerebrospinal fluid volume and thoracolumbosacral cerebrospinal fluid volume using magnetic resonance images in pediatric patients from neonates and infants to adolescents. Methods Spinal magnetic resonance images of 500 pediatric patients (age <18 years) were reviewed. The lumbosacral cerebrospinal fluid volumes of 418 patients and thoracolumbosacral cerebrospinal fluid volumes of 248 patients were measured. The relationship between cerebrospinal fluid volumes and age, height, and weight were evaluated. The lumbosacral and thoracolumbosacral cerebrospinal fluid volumes per weight were calculated to elucidate developmental changes. Results The lumbosacral and thoracolumbosacral cerebrospinal fluid volumes showed linear correlations with height (r2 = 0.730 and r2 = 0.661, respectively), whereas they showed curvilinear correlations with age (r2 = 0.752 and r2 = 0.717, respectively) and weight (r2 = 0.734 and r2 = 0.734, respectively). The mean lumbosacral cerebrospinal fluid volume per weight (mL/kg) was 0.85 (standard deviation [SD]: 0.19, 95% confidence interval [CI]: 0.81‐0.90) in neonates and infants, 0.86 (SD: 0.22, 95% CI: 0.83‐0.89) in toddlers and preschoolers, 0.71 (SD: 0.26, 95% CI: 0.66‐0.76) in schoolers, and 0.54 (SD: 0.20, 95% CI: 0.49‐0.60) in adolescents. The mean thoracolumbosacral cerebrospinal fluid volume per weight (mL/kg) was 1.95 (SD: 0.37, 95% CI: 1.86‐2.04) in neonates and infants, 1.82 (SD: 0.41, 95% CI: 1.75‐1.88) in toddlers and preschoolers, 1.38 (SD: 0.40, 95% CI: 1.23‐1.52) in schoolers, and 0.99 (SD: 0.34, 95% CI: 0.45‐1.53) in adolescents. Conclusion The lumbosacral and thoracolumbosacral cerebrospinal fluid volumes in pediatric patients were much smaller than previously presented values, showing linear correlations with height, and demonstrate curvilinear correlations with age and weight.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lumbosacral and thoracolumbosacral cerebrospinal fluid volume changes in neonates, infants, children, and adolescents: A retrospective magnetic resonance imaging study

Jang

Lee

Seo

et al. 2018

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Gerhart

Watt

Edginton

et al. 2019

CPT Pharmacom & Syst Pharma

View full text Add to dashboard Cite

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular filtration and metabolism. The model was optimized using 760 plasma samples from 166 infants (median postmenstrual age (range) 28 weeks (24–50)) and 27 cerebrospinal fluid ( CSF ) samples from 22 infants ( postmenstrual age 28 weeks (24–33)). Simulations evaluated achievement of the surrogate efficacy target of area under the unbound concentration‐time curve ≥ 400 mg • hour/L over the dosing interval in plasma and CSF using dosing guidelines. Average fold error of predicted concentrations was 0.73 and 1.14 for plasma and CSF , respectively. Target attainment in plasma and CSF was reached faster after incorporating a loading dose of 25 mg/kg. PBPK modeling can be useful in exploring CNS kinetics of drugs in children.

show abstract

Regional Anesthesia for Infants and Children

Johnson

Gibson

2019

A Guide to Pediatric Anesthesia

View full text Add to dashboard Cite

Cerebrospinal fluid volume in neonates undergoing spinal anaesthesia: a descriptive magnetic resonance imaging study

Cited by 22 publications

References 14 publications

Lumbosacral and thoracolumbosacral cerebrospinal fluid volume changes in neonates, infants, children, and adolescents: A retrospective magnetic resonance imaging study

Lumbosacral and thoracolumbosacral cerebrospinal fluid volume changes in neonates, infants, children, and adolescents: A retrospective magnetic resonance imaging study

Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Regional Anesthesia for Infants and Children

Contact Info

Product

Resources

About