Cerebrovascular accident following MDMA ingestion

Muntan, Charles D.; Tuckler, V.

doi:10.1007/bf03161008

Cited by 14 publications

(4 citation statements)

References 5 publications

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“…In all 50 cases designated as psychostimulant users, there was evidence for recent or historical psychostimulant located in one or more of the following reports: coroner's (33 cases), forensic pathology (37), police (37), and toxicology (37). Evidence for psychostimulant use was documented in one source (7 cases), two sources (11), three sources (13), and all four sources (19). For all other cases, psychostimulant use was not documented in any source, or noted in the cause of death.…”

Section: Data Available For Inspectionmentioning

confidence: 99%

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Psychostimulant Use and Fatal Stroke in Young Adults

Darke

Duflou

Kaye

et al. 2019

Journal of Forensic Sciences

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Psychostimulant use is associated with increased stroke risk. To determine the proportion of psychostimulant users among fatal strokes in young adults (15–44 years), all cases were retrieved from the National Coronial Information System (1/1/2009–31/12/2016). A total of 279 cases were identified: hemorrhagic (259), ischemic (8), thrombotic (8), and mycotic (4). Fifty (17.9%) were identified as psychostimulant users. Psychostimulants in blood were detected in 37/45 where toxicology was available, predominantly methamphetamine (32/45). Hemorrhagic strokes in the psychostimulant group were more likely to be intraparenchymal (OR 2.33). Psychostimulant users were less likely to be obese (OR 0.31), but more likely to have a history of tobacco use (OR 2.64). No psychostimulant user had a previous stroke history, was gravid/postpartum, or diagnosed with cerebral vasculitis or endocarditis. The work illustrates the substantial role of psychostimulant use in fatal strokes among young adults. In cases of hemorrhagic stroke among young adults, psychostimulant use should be considered.

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Section: Data Available For Inspectionmentioning

confidence: 99%

“…One major concern is a substantially increased stroke risk: methamphetamine has a fivefold risk for hemorrhagic stroke, and cocaine has a twofold risk for both hemorrhagic and ischemic stroke . MDMA‐related hemorrhagic strokes appear less common, but have been reported . Such strokes may occur following any route of psychostimulant administration .…”

mentioning

confidence: 99%

Psychostimulant Use and Fatal Stroke in Young Adults

Darke

Duflou

Kaye

et al. 2019

Journal of Forensic Sciences

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“…MDMA masum bir madde değildir, birçok yan etkisi bulunmaktadır. Kullanan kişilerde akut miyokard enfarktüsü, rabdomiyoliz, dissemine intravasküler koagülasyon, hiponatremi, akut böbrek yetmezliği, hepatit, hipertermi, serebral enfarkt ve koma bildirilmiştir (10). Ekstazinin böbrek üzerindeki yan etkileri de oldukça fazladır.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

Bilateral Renal Infarction Due to Ecstasy Usage

Güngör¹,

Törün²,

Kesler³

et al. 2017

Turk Neph Dial Transpl

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ÖzRenal enfarktüs bilateral yan ağrısının nadir görülen bir nedenidir. Etiyolojide en sık atrial fibrilasyon ve buna bağlı tromboemboli sorumludur. Madde bağımlılığı, örneğin ekstazi kullanımı renal enfarktüsün çok nadir bir nedenidir. Burada 35 yaşındaki erkek hastada görülen bilateral enfarktüste diğer nedenler ekarte edildikten sonra ekstazi kullanımı sorumlu bulunmuş ve sunulmuştur.anahTaR SÖzCüKleR: Ağrı, Renal enfarktüs, Ekstazi abSTRaCT Renal infarction is a rare cause of bilateral loin pain. The most common etiologic reason is thromboembolism due to atrial fibrillation. Abuse of drugs such as ecstasy is a very rare cause of renal infarction. Here, we present a case diagnosed with bilateral renal infarction due to ecstasy usage after excluding other reasons. Key wORdS: Pain, Renal infarction, Ecstasy GİrİşRenal enfarktüs, tüm acil servis başvu-rularının yaklaşık olarak % 0,007'sini oluşturur (1). Renal enfarktüs aynı zamanda nefroloji pratiğinde de az rastlanan ancak önemli olabilecek bir problemdir. Acil servise ve nefroloji polikliniğine yan ağrısı nedeniyle başvuran hastalarda öncelikle üriner sistem enfeksiyonu veya taş hastalığı düşünülmekte, aynı semptomları gösterebilen renal enfarktüs daha az oranda akla gelmektedir. Literatürde renal enfarktüs hastalarına bakıldığında etiyolojide genellikle atrial fibrilasyon, travma ve hiperkoagülabiliteye yol açabilecek nedenler sorumlu tutulmuştur (2-5). İlginç olarak bir olguda renal enfarktüse neden olabilecek herhangi bir patolojiye rastlanmamış ve ekstazi kullanımı sorumlu tutulmuştur (6).Ekstazi etken madde olarak 3,4-metilen dioksi metamfetamin (MDMA) içeren bir amfetamindir. Ekstazinin etkisi, alındıktan 20-60 dakika sonrasında kendisini gösterir ve bu etki 4-6 saat kadar devam eder. Temel etkisi kuvvetli bir uyarıcı olmasıdır. Enerjinin artığı hissini verirken uyku ve yorgunluk hissini bloke eder (7). Captagon ise etken madde olarak fenetylline içeren amfetamin benzeri özellikler taşıyan bağımlılık yapan bir maddedir. Uyanık tutma ve cesaret verme özellikleri kullanımını artırmaktadır (8). Her iki ilacın da önemli yan etkileri bulunmaktadır. Literatürde captagon kullanımına bağlı akut miyokard infarktüsü (9) ve ekstazi kullanımına bağlı renal enfarktüs olgusu bildirilmiştir.Biz burada bilateral renal enfarktüs nedeniyle kliniğimize yatırılan, ekstazi ve captagon kullanımı bulunan ve çok yüksek olasılıkla ekstaziye bağlı renal enfarktüs gelişen hastayı oldukça nadir görülmesi nedeniyle sunuyoruz. OlGu Sunumu35 yaşındaki erkek hasta bir gün önce başlayan ve giderek artan iki taraflı yan ağrısı ve bulantı yakınmaları ile hastanemiz

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“…Psychosis develops during substance use and may not resolve even after withdrawal or withdrawal (10). Stroke risk appears to be significantly increased with cocaine use (11)(12)(13). The addictive nature of this drug can cause significant acute and long-term psychological effects in humans (14).…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction

et al. 2022

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BackgroundPrevious voxel-based morphometric (VBM) and functional magnetic resonance imaging (fMRI) studies have shown changes in brain structure and function in cocaine addiction (CD) patients compared to healthy controls (HC). However, the results of these studies are poorly reproducible, and it is unclear whether there are common and specific neuroimaging changes. This meta-analysis study aimed to identify structural, functional, and multimodal abnormalities in CD patients.MethodsThe PubMed database was searched for VBM and task-state fMRI studies performed in CD patients between January 1, 2010, and December 31, 2021, using the SEED-BASE d MAP software package to perform two independent meta-groups of functional neural activation and gray matter volume, respectively. Analysis, followed by multimodal analysis to uncover structural, functional, and multimodal abnormalities between CD and HC.ResultsThe meta-analysis included 14 CD fMRI studies (400 CD patients and 387 HCs) and 11 CD VBM studies (368 CD patients and 387 controls). Structurally, VBM analysis revealed significantly lower gray matter volumes in the right superior temporal gyrus, right insula, and right retrocentral gyrus than in the HC. On the other hand, the right inferior parietal gyrus increased in gray matter (GM) volume in CD patients. Functionally, fMRI analysis revealed activation in the right temporal pole, right insula, and right parahippocampal gyrus. In the right inferior parietal gyrus, the left inferior parietal gyrus, the left middle occipital gyrus, and the right middle frontal gyrus, the degree of activation was lower.ConclusionThis meta-analysis showed that CD patients had significant brain GM and neural changes compared with normal controls. Furthermore, multi-domain assessments capture different aspects of neuronal alterations in CD, which may help develop effective interventions for specific functions.

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Cerebrovascular accident following MDMA ingestion

Cited by 14 publications

References 5 publications

Psychostimulant Use and Fatal Stroke in Young Adults

Psychostimulant Use and Fatal Stroke in Young Adults

Bilateral Renal Infarction Due to Ecstasy Usage

Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction

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