2018
DOI: 10.1155/2018/4109358
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Cerebrovascular Complications and Infective Endocarditis: Impact of Available Evidence on Clinical Outcome

Abstract: Background. Infective endocarditis (IE) is a life-threatening disease. Its epidemiological profile has substantially changed in recent years although 1-year mortality is still high. Despite advances in medical therapy and surgical technique, there is still uncertainty on the best management and on the timing of surgical intervention. The objective of this review is to produce further insight into the short- and long-term outcomes of patients with IE, with a focus on those presenting cerebrovascular complicatio… Show more

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Cited by 18 publications
(14 citation statements)
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“…Choosing right medication regimen, especially antibiotic regimen, requires a combination of the characteristics of pathogenic microorganism, the duration of medication application, adverse events caused by medication, and other outcomes (Cahill and Prendergast, 2016). For example, IE, one of the most common diseases associated with heart-related infectious diseases, is hard to be cured due to the characteristics of the infection itself, the bacterial species, and frequent comorbidities of the patients (del Rio et al, 2014; Schirone et al, 2018). A long treatment cycle (4–6 weeks of intravenously administered antibiotic agents) used to be required, and aminoglycoside often brings about side effect of nephrotoxicity (Baddour et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Choosing right medication regimen, especially antibiotic regimen, requires a combination of the characteristics of pathogenic microorganism, the duration of medication application, adverse events caused by medication, and other outcomes (Cahill and Prendergast, 2016). For example, IE, one of the most common diseases associated with heart-related infectious diseases, is hard to be cured due to the characteristics of the infection itself, the bacterial species, and frequent comorbidities of the patients (del Rio et al, 2014; Schirone et al, 2018). A long treatment cycle (4–6 weeks of intravenously administered antibiotic agents) used to be required, and aminoglycoside often brings about side effect of nephrotoxicity (Baddour et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…In IE, specific factors that increase the risk of AIS include prior strokes, staphylococcus infection, vegetations on the mitral valve, especially the anterior leaflet, multivalvular vegetations, valvular abscesses and vegetations larger than 10 millimetres in length [32][33][34]. Staphylococcus infection (HR = 2.0), mitral valve vegetations (HR = 2.2) and valvular abscesses (HR = 2.7) all increase the risk of AIS by equal to or more than double [33].…”
Section: Aetiology Of Acute Ischaemic Stroke In the Setting Of Infective Endocarditismentioning
confidence: 99%
“…Infective endocarditis (IE) is a well-described cause of cardioembolic acute ischemic stroke (AIS) that presents with various potential complications. 1 - 3 AIS manifests in up to 40% of IE patients and is associated with a 30% mortality rate. 1 , 2 , 4 , 5 Furthermore, AIS can evolve into cerebral or subarachnoid hemorrhages.…”
Section: Introductionmentioning
confidence: 99%