Cerebrovascular hemodynamic correlates of aging in the Lou/c rat: A model of healthy aging

d-Serine in the aging hippocampus

“…which displays many assets (no insulino-and leptino-resistance, low growth hormone and IGF1 production, preserved cerebrovascular hemodynamics, etc.) to constitute a model of healthy aging [56][57][58]. Behavioral investigations indicate that LOU/C rats, which show an increased median lifespan (50% of survivors) compared to other strains of rats, do not develop deficits of hippocampaldependent memory at very advanced ages [59][60][61].…”

Optical imaging of acute epileptic networks in mice

“…35,36 In short, reflectance images from each LED wavelength were recorded with the CCD camera and interpreted as changes in attenuation (optical density) ΔOD ¼ logðI 0 ∕IÞ, where I is the reflected light intensity and I 0 is the incident light intensity. Relative changes in HbO 2 and HbR were found using the modified Beer-Lambert law 37 and a Moore-Penrose pseudoinverse:…”

Biophysical model estimation of neurovascular parameters in a rat model of healthy aging

“…It exhibits longer lifespan free of disease, low adiposity throughout life and preserved neuroendocrine and metabolic functions (Veyrat-Durebex et al, 2005;Alliot et al, 2002;Kappeler et al, 2004;Duque et al, 2009) and memory capacities when compared to most laboratory rat strains (Kollen et al, 2008). As mentioned earlier, we recently performed a study examining the vascular correlates of aging in this model (Dubeau et al, 2011). Experiments performed showed that functional responses, assessed in the anesthetized LOU/c rat, were modified with age.…”

“…In particular, invasive imaging of animal models provides a rich source of information by allowing extensive control on the experimental conditions. In a recent study (Dubeau et al, 2011), we reported age-related changes in the hemodynamic response measured in rats by multimodal optical imaging. This work will further explore the nature of these changes and interpret them in the light of biophysical models.…”

“…Therefore this paper opens with a study of parameter estimability in three selected models on simulated data. These simulations yield a methodology for estimating biophysical parameters from multimodal data, which is then applied to our previously reported data (Dubeau et al, 2011). The aims of this work are thus 1) to validate and characterize parameter estimability in three selected biophysical models and 2) to estimate and compare parameters from experimental data in groups of young (Y), old (O) and very old (VO) animals.…”