Cerebrovascular Response in Migraineurs During Prophylactic Treatment with Acupuncture: A Randomized Controlled Trial

Wallasch, Thomas-Martin; Weinschuetz, Thomas; Mueller, Brett H.; Kropp, Peter

doi:10.1089/acm.2011.0308

Cited by 25 publications

(35 citation statements)

References 41 publications

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“…As we had modified selection criteria for this update, we reassessed the 22 trials included in the previous version for eligibility. Five new trials met the revised selection criteria (Facco 2013; Li 2012; Wallasch 2012; Wang 2015; Zhao 2014), while five trials included in the previous version or our review had to be excluded (Baust 1978; Doerr-Proske 1985; Dowson 1985; Henry 1985; Wylie 1997; see Characteristics of excluded studies). …”

Section: Resultsmentioning

confidence: 99%

“…All trials used parallel-group designs; there were no cross-over studies. Fifteen trials included a sham acupuncture control group (Alecrim 2005; Alecrim 2006; Alecrim 2008; Ceccherelli 1992; Diener 2006; Facco 2008; Li 2012; Linde K 2005; Linde M 2004; Vincent 1989; Wallasch 2012; Wang 2015; Weinschütz 1993; Weinschütz 1994; Zhao 2014), five a no-acupuncture control group (Facco 2008; Jena 2008; Linde K 2005; Linde M 2000; Vickers 2004), and five a comparator group receiving prophylactic drug treatment (Allais 2002; Diener 2006; Facco 2013; Hesse 1994; Streng 2006). Sixteen trials were performed in a single centre and six were multicentre trials.…”

Section: Resultsmentioning

confidence: 99%

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Acupuncture for the prevention of episodic migraine

Linde

Allais

Brinkhaus

et al. 2016

Cochrane Database of Systematic Reviews

210

217

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Acupuncture for the prevention of episodic migraine

Linde

Allais

Brinkhaus

et al. 2016

Cochrane Database of Systematic Reviews

210

217

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“…One study evaluated the effect of acupuncture on cerebrovascular response in migraineurs by transcranial Doppler ultrasound, and showed that prophylactic treatment of migraine by standardised acupuncture might positively influence the dysfunction of the cerebrovascular response to autonomic stimuli, but not the cerebral vasotonus during rest. 12 Conventional prophylactic drugs such as amitriptyline may cause dry mouth, drowsiness and orthostatic hypotension. Considering the side effects of drugs reported by most patients even with minimal therapeutic dosage and considering the minimal complications or side effects of acupuncture, acupuncture is recommended as an adjunct to conventional prophylactic drugs.…”

Section: Discussionmentioning

confidence: 99%

A Sham-Controlled Trial of Acupuncture as An Adjunct in Migraine Prophylaxis

et al. 2014

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Background Migraine is one of the most common types of headache, with significant socioeconomic effects. Prophylactic drugs are used to prevent migraine headaches but are unpromising. Objective To assess the effects of adding acupuncture to conventional migraine prophylaxis. Methods One hundred patients with migraine (41 male, 59 female), in whom prophylactic drugs had not produced a fall of at least 50% in the number of attacks, entered the study. The patients were randomised into two groups, sham and true acupuncture. The patients in both groups continued their prophylactic treatment and received 12 sessions of either true or sham acupuncture. Each session was 30 min and was repeated three times a week. The number of headaches in the two groups was compared at baseline, and at the end of four successive months. Results There was no significant difference in the frequency of attacks between the two groups before intervention. After 1 month, the frequency of attacks each month decreased from 5.1 (0.8) to 3.4 (1.2) in the true acupuncture group, and from 5.0 (0.8) to 4.4 (1.1) in the sham acupuncture group (a significant difference, p<0.001). The frequency continued to decrease in month 2 but increased in months 3 and 4; however, it was still significantly lower than baseline, and the difference remained significant after month 4. Conclusions Acupuncture is applicable as an adjunct to prophylactic drugs in migraineurs in whom the number of attacks does not fall with prophylactic medication.

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“…[8] found that there were no differences in clinical symptoms which had been seen between active versus sham acupuncture. At the same time, a number of trials have the same situation in migraine [9, 10], low back pain [11, 12] and some other diseases. All of those trials did not find verum acupuncture more effective than sham acupuncture and did not emphasize that the verum acupuncture group must have the needle sensation of de qi .…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of strengthened stimulation during acupuncture for the treatment of allergic rhinitis: study protocol for a randomized controlled trial

Chen

Zhang

Jiang

et al. 2014

Trials

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BackgroundThe traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary to achieve the best therapeutic effect. However, the notion that de qi must be achieved for maximum benefit has not been confirmed by modern scientific evidence. This study aims to compare the efficacy of acupuncture with either strong (intended to elicit de qi) or weak stimulation among patients with allergic rhinitis.Methods/DesignThis study compares real versus sham acupuncture in 140 patients with a history of persistent allergic rhinitis (PER) or intermittent allergic rhinitis (IAR) and with a positive skin prick test (SPT). The trial will be conducted in the Teaching Hospital of Chengdu University of Traditional Chinese Medicine (China). In the study, patients will be randomly assigned into two groups by computer-generated randomization and assessed prior to treatment. They will then receive 12 sessions of treatments for 4 consecutive weeks and have a follow-up phase lasting 12 weeks. The main outcome measures include the primary and secondary indicators. Primary indicators are subjective symptoms scores as evaluated by visual analogue scales (VAS), rhinoconjunctivitis quality of life questionnaires (RQLQ), and the Modified Massachusetts General Hospital acupuncture sensation scale, Chinese version (C-MMASS). The secondary indicators are the results of laboratory examinations, such as serum allergen-specific immunoglobulin E (sIgE) nasal inflammatory cells counts (mast cells, eosinophils, and T cells), and nitric oxide concentration in nasal excretion. The use of anti-allergic medication will also be recorded as one of the secondary indicators. Furthermore, adverse events will be recorded and analyzed. Intention-to-treat analysis (ITT) and per-protocol (PP) analysis will be performed to test and verify the results in this trial.DiscussionThe results of this trial will demonstrate the efficacy of using acupuncture to treat allergic rhinitis and verify whether the effectiveness of acupuncture is related to the needle sensation de qi.Trial registrationChinese Clinical Trial Registry: ChiCTR-TRC-13003594 (registered on 16 August 2013, and the first patient was randomized on 27 September 2013).Electronic supplementary materialThe online version of this article (doi:10.1186/1745-6215-15-301) contains supplementary material, which is available to authorized users.

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Cerebrovascular Response in Migraineurs During Prophylactic Treatment with Acupuncture: A Randomized Controlled Trial

Abstract: The findings indicate that prophylactic treatment of migraineurs by standardized acupuncture might positively influence the dysfunction of the cerebrovascular response to autonomic stimuli, but not the cerebral vasotonus during rest.

Cited by 25 publications

References 41 publications

Acupuncture for the prevention of episodic migraine

Acupuncture for the prevention of episodic migraine

A Sham-Controlled Trial of Acupuncture as An Adjunct in Migraine Prophylaxis

Effectiveness of strengthened stimulation during acupuncture for the treatment of allergic rhinitis: study protocol for a randomized controlled trial

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