Cerebrovascular Response to Repetitive Visual Stimulation in Interictal Migraine with Aura

Nedeltchev, Krassen; Arnold, Marcel; Schwerzmann, Markus; Nirkko, Arto C.; Lagger, F.; Mattle, HP; Sturzenegger, Mathias

doi:10.1111/j.1468-2982.2004.00740.x

Cited by 35 publications

(28 citation statements)

References 37 publications

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“…PCAs (using visual stimuli during an attack-free period) (20). Ayata et al evaluated the efficacy of prophylactic migraine drugs on CSD using a rat model.…”

Section: Discussionmentioning

confidence: 99%

The effects of topiramate therapy on cerebral metabolism in migraine with aura patients

Karadaş

Gül²,

Öztürk³

et al. 2014

Turkish Neurosurgery

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AIm:Topiramate is an antiepileptic drug with multiple mechanisms of action that is also used for migraine prophylaxis. This study aimed to investigate the efficacy of topiramate therapy for migraine prophylaxis, based on vasomotor reactivity ([VMR] an indicator of cerebral autoregulation), and to identify changes in cerebral hemodynamics during the treatment. mATERIAL and mETHods:We included 20 migraine (with aura) patients (group 1) and 20 healthy controls (group 2) in the study. Transcranial Doppler monitoring was performed in both groups with patients in the supine and resting position. Using a two-sided temporal window at depths of 45-60 mm for the middle cerebral artery (MCA) and depths of 60-70 mm for the posterior cerebral artery (PCA), basal flow rates and VMR values were measured. Group 1 initially received 25 mg/d of topiramate orally, and then the dose was increased 25 mg every week. At the fourth week; the optimal dose was increased to 50 mg b.i.d. and the treatment was continued at this dose. Transcranial Doppler parameters were re-evaluated 2 months after treatment. In addition, the number of attacks per month, duration of pain, and visual analog scale (VAS) scores obtained before the treatment and 2 months after the treatment in group 1 were compared.REsuLTs: Basal flow rates and VMR values recorded from the right and left MCA in group 1 were significantly higher than those in the control group (P < 0.05). Flow velocities obtained from the right and left MCA, and the VMR values in group 1 after topiramate treatment did not differ significantly from those in the control group (P > 0.05). In addition, the number of attacks, duration of pain, and VAS scores in group 1 were significantly lower after the treatment than before the treatment (P < 0.05). CoNCLusIoN:Topiramate is an effective prophylactic treatment in migraine with aura patients and appeared to play a positive role in the regulation of cerebrovascular autonomic control. BuLGuLAR: Topiramat tedavisi öncesi migren grubunda OSA bazal akım hızları ile VMR değerleri istatistiksel olarak anlamlı derecede (p<0,05) yüksek bulundu. Migren grubunda topiramat tedavi sonrası saptanan, sağ ve sol OSA'dan elde edilen bazal akım hızları ile VMR değerleri, kontrol grubu ile karşılaştırıldığında farklılık saptanmadı (p>0,05).soNuÇ: Migrenli hastaların proflaktik tedavisinde, topiramatın iyi bir seçenek olduğu ve serebrovasküler otonomik kontrolün regülasyonunda rol oynadığı söylenebilir.

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“…PCAs (using visual stimuli during an attack-free period) (20). Ayata et al evaluated the efficacy of prophylactic migraine drugs on CSD using a rat model.…”

Section: Discussionmentioning

confidence: 99%

The effects of topiramate therapy on cerebral metabolism in migraine with aura patients

Karadaş

Gül²,

Öztürk³

et al. 2014

Turkish Neurosurgery

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“…6 Data on the neurovascular coupling (metabolic regulation) during visual stimulation protocols showed a higher flow activation in interictal migraine. 31 Altogether, vasomotor function and vasoneural coupling are altered in migraine, but the underlying mechanisms are not fully understood. A possible hint could be that the pathophysiology of migraine is linked to monoaminergic brain stem nuclei involved with cerebral blood flow control.…”

Section: Previous Studies On Migraine and Autoregulationmentioning

confidence: 99%

Cerebellar and Cerebral Autoregulation in Migraine

Reinhard

Schork

Allignol

et al. 2012

Stroke

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Background and Purpose-Silent ischemic brain lesions frequently occur in migraine with aura and are most often located in cerebellar border zones. This may imply an impairment of cerebellar blood flow autoregulation. This study investigated the characteristics of interictal cerebellar autoregulation in migraine with and without aura. Methods-Thirty-four patients (nϭ17, migraine without aura; nϭ17, migraine with aura) and 35 age-and sex-matched controls were studied. Triple simultaneous transcranial Doppler monitoring of one posterior inferior cerebellar artery, right posterior cerebral artery, and left middle cerebral artery was performed. Autoregulation dynamics were assessed from spontaneous blood pressure fluctuations (correlation coefficient index Dx) and from respiratory-induced 0.1-Hz blood pressure oscillations (phase and gain). Results-Compared with controls, the autoregulatory index Dx was higher (indicating less autoregulation) in the posterior inferior cerebellar artery (Pϭ0.0062) and middle cerebral artery (Pϭ0.0078) in migraine with aura, but not in migraine without aura. Phase and gain did not significantly differ between migraine patients and controls. No significant associations of autoregulation with clinical factors were found, including frequency of migraine attacks and orthostatic intolerance. Conclusions-This

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“…14 -17 This concept implicates that there could be a lack of cortical inhibition of neuronal activity, leading to a prolonged and widely distributed increased blood flow demand. In such a condition, an increase of blood flow inducible by physiological stimuli 9 or carbon dioxide 18 is less pronounced, mimicking a disturbed vasomotor reactivity and, hence, a disturbed cerebral autoregulation. In this model, the stimuli dependency of the findings of Nedeltchev et al 9 could be attributable to the lack of adequate inhibition.…”

Section: Discussionmentioning

confidence: 99%

The Linear Behavior of the System Middle Cerebral Artery Flow Velocity and Blood Pressure in Patients With Migraine

Müller¹,

Marziniak²

2005

Stroke

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Background and Purpose-Migraine is considered a disorder of the autonomic nervous system. We used the frequency analysis of dynamic cerebral autoregulation to assess whether blood flow regulation disturbances can be found at the frequencies at which sympathetic and parasympathetic activity is present. Methods-We measured simultaneously mean arterial blood pressure (BP) and the mean blood velocity (V) in the middle cerebral artery using transcranial Doppler ultrasound in 33 healthy controls (mean ageϮSD; 36Ϯ13 years) and in 22 patients with migraine (mean age; 39Ϯ7 years). Apart from assessing spectral power density for BP and V, we calculated the transfer function parameters gain, phase, and coherence at the frequency range between 0.0 and 0.25 Hz. Results-Compared with the controls, the spectral power density of BP and V exhibited a maximum magnitude of 10 26 in the migraine patients, whereas the maximum magnitude of BP and V in the controls was 10

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Cerebrovascular Response to Repetitive Visual Stimulation in Interictal Migraine with Aura

Cited by 35 publications

References 37 publications

The effects of topiramate therapy on cerebral metabolism in migraine with aura patients

The effects of topiramate therapy on cerebral metabolism in migraine with aura patients

Cerebellar and Cerebral Autoregulation in Migraine

The Linear Behavior of the System Middle Cerebral Artery Flow Velocity and Blood Pressure in Patients With Migraine

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