Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury

Niemiec, Stephen; Hilton, Sarah A.; Wallbank, Alison; Azeltine, Mark; Louiselle, Amanda; Elajaili, Hanan; Allawzi, Ayed; Xu, Jie; Mattson, Courtney; Dewberry, Lindel C.; Hu, Junyi; Singh, Sushant; Sakthivel, T.; Sea, Sudipta; Nozik‐Grayck, Eva; Smith, Bradford J.; Zgheib, Carlos; Liechty, Kenneth W.

doi:10.1016/j.nano.2021.102388

Cited by 35 publications

(38 citation statements)

References 42 publications

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“…The TA-mediated AgNP-treated group also showed significantly increased percentages of IFN-gamma+ CD8+ T-cells, activated B cells and plasma cells, while the spleens contained significantly higher percentages of IFN-gamma+ NK cells and effector-memory CD8+ T cells compared to NaCl-treated group. Further, the AgNP-treated animals showed significantly better sera titers of anti-HSV-2 neutralization antibodies than the NaCl-treated animals [83]. AgNPs interaction with HIV-1 in size-dependent manner and that the bound particles exhibit regular spatial relationships.…”

Section: Silver Nanoparticlesmentioning

confidence: 85%

Design of Micro- and Nanoparticles: Self-Assembly and Application

2022

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Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Preface to "Design of Micro-and Nanoparticles: Self-Assembly and Application"Micro-/nanoparticles (M&NPs) have attracted researchers'interest due to their unique chemical and physical properties. Recent advances in the synthesis of M&NPs (metallic, metal oxide, silica, polymeric, lipid-based, supramolecular, colloidal, and carbon-based M&NPs) have offered exciting opportunities for many applications, such as catalysis, plasmonics, sensors, magnetism, drug delivery, and nanomedicine. The use of self-assembly for the synthesis or modification of M&NPs provides unlimited possibilities for designing nanomaterials with desired properties. This reprint presents the most recent developments in the synthesis, modification, properties, and applications of M&NPs. This book will be useful to scientists of diverse backgrounds, i.e., material science, organic and inorganic chemistry, biochemistry, and biology.

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Section: Silver Nanoparticlesmentioning

confidence: 85%

Design of Micro- and Nanoparticles: Self-Assembly and Application

2022

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“…Various nanoparticle strategies have been used to modulate lung fibrosis. These include cerium oxide nanoparticle delivery of microRNA-146a for treatment of acute lung injury and fibrosis ( 45 ). PEI nanoparticles incorporating GSE4 were delivered via airway postbleomycin, which increased telomerase activity and decreased DNA damage and showed antifibrotic activity ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis

Singh

Chakraborty

Wong

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Significance Current therapies for pulmonary fibrosis (PF) focus on slowing disease progression and reducing functional decline in patients by dampening the activation of fibroblasts and other implicated cells. There is a need for strategies that target the essential cells and signaling pathways involved in disease pathogenesis. Monocyte-derived macrophages (Mo-Macs) are known to express profibrotic genes and are involved in the pathogenesis of PF. Our results show that engineered mannosylated albumin nanoparticles specifically targeted disease-inducing Mo-Macs, and further, that nanoparticles efficiently delivered small-interfering RNA against profibrotic cytokine tumor growth factor β1 to prevent bleomycin-induced lung fibrosis.

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“…159 Studies show that when nanoceria are associated with miR146a, improvement in lung capacity occurs, including improved lung mechanics, increased tissue resistance and inspiratory capacity, and improved lung elastance. 164 Furthermore, in the fight against coronaviruses, copper nanoparticles, or copper oxide, may be an excellent option among the application possibilities of nanotechnology. 165 Copper is naturally present in many species of plants and animals.…”

Section: The Potential Use Of Carbon Nanotubes and Metallic Nanoparti...mentioning

confidence: 99%

Coronavirus and Carbon Nanotubes: Seeking Immunological Relationships to Discover Immunotherapeutic Possibilities

Lima¹,

Octaviano²,

Piqueira³

et al. 2022

IJN

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Since December 2019, the world has faced an unprecedented pandemic crisis due to a new coronavirus disease, coronavirus disease-2019 (COVID-19), which has instigated intensive studies on prevention and treatment possibilities. Here, we investigate the relationships between the immune activation induced by three coronaviruses associated with recent outbreaks, with special attention to SARS-CoV-2, the causative agent of COVID-19, and the immune activation induced by carbon nanotubes (CNTs) to understand the points of convergence in immune induction and modulation. Evidence suggests that CNTs are among the most promising materials for use as immunotherapeutic agents. Therefore, this investigation explores new possibilities of effective immunotherapies for COVID-19. This study aimed to raise interest and knowledge about the use of CNTs as immunotherapeutic agents in coronavirus treatment. Thus, we summarize the most important immunological aspects of various coronavirus infections and describe key advances and challenges in using CNTs as immunotherapeutic agents against viral infections and the activation of the immune response induced by CNTs, which can shed light on the immunotherapeutic possibilities of CNTs.

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Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury

Cited by 35 publications

References 42 publications

Design of Micro- and Nanoparticles: Self-Assembly and Application

Design of Micro- and Nanoparticles: Self-Assembly and Application

Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis

Coronavirus and Carbon Nanotubes: Seeking Immunological Relationships to Discover Immunotherapeutic Possibilities

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