Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice

Adebayo, Olayinka A.; Akinloye, Oluyemi; Adaramoye, Oluwatosin A.

doi:10.1007/s12011-019-01696-5

Cited by 65 publications

(53 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pretreatment of CeO 2 NPs attenuated the activity of antioxidant enzymes and expression of Bcl 2 and Cox 2 . This report again supports the antioxidative role of CeO 2 NPs [103].…”

Section: Discussionsupporting

confidence: 84%

A Comprehensive Assessment of Hepatotoxicity Induced by Engineered Nanoparticles- A Review

Rana¹

2020

J Toxicol Risk Assess

View full text Add to dashboard Cite

Liver is the major detoxifying centre of the body. It removes xenobiotics and their metabolites through metabolism or biliary excretion. Hepatocytes constitute 80% of total liver mass and play a major role in storage, synthesis, metabolism and redistribution of essential molecules. Liver has been known to accumulate > 90% of nanomatrerials translocated from other organs. Bioconcentration of nanoparticles may lead to impairment of structure and function of hepatic cells. Therefore, it is critical to review the information available on NP induced hepatotoxicity, underline the gaps in our knowledge on their toxicity and propose future strategies for nanosafety. Present review discusses recent researches available on the hepatotoxicity of engineered nanoparticles viz. carbon nanotubes (CNTs), nanoparticles of silver (AgNPs), gold (AuNPs), platinum (PtNPs), zinc oxide (ZnONPs), cadmium sulphide (CdSNPs), titanium dioxide (TiO 2 NPS), iron oxide (IONPs), copper (CuNPs), cerium oxide (CeO 2 NPs), silicon (SiO 2 NPs) and dendrimers in cell as well as animal models. In vitro and in vivo studies show that these NPs elicit specific effects on serum enzymes, inflammatory cytokines, oxidative stress, gene expression and morphology of hepatocytes. Antioxidants like vitamin C and α lipoic acid can reverse the cell injury in some cases. Further, protective effects of ZnONPs and CeO 2 NPs against experimental hepato-carcinogenesis have also been highlighted. It is suggested that further efforts are required to address health issues concerned with nanomaterials.

show abstract

“…Pretreatment of CeO 2 NPs attenuated the activity of antioxidant enzymes and expression of Bcl 2 and Cox 2 . This report again supports the antioxidative role of CeO 2 NPs [103].…”

Section: Discussionsupporting

confidence: 84%

A Comprehensive Assessment of Hepatotoxicity Induced by Engineered Nanoparticles- A Review

Rana¹

2020

J Toxicol Risk Assess

View full text Add to dashboard Cite

show abstract

“…[132,133] Finally, cerium oxide NP (<10 nm) pretreatment of rats exposed to DEN reduced oxidative stress and inflammation markers. [134] Antioxidant markers and apoptotic markers were significantly reduced, showing that cerium oxide NPs were able to reduce the effects of DEN toxicity.…”

Section: Metallic Nps and Hepatocellular Cancermentioning

confidence: 96%

All Roads Lead to the Liver: Metal Nanoparticles and Their Implications for Liver Health

Boey

2020

Small

View full text Add to dashboard Cite

Metal nanoparticles (NPs) are frequently encountered in daily life, and concerns have been raised about their toxicity and safety. Among which, they naturally accumulate in the liver after introduction into the body, independent of the route of administration. Some NPs exhibit intrinsic pharmaceutical effects that are related to their physical parameters, and their inadvertent accumulation in the liver can exert strong effects on liver function and structure. Even as such physiological consequences are often categorically dismissed as toxic and deleterious, there are cell type‐specific and NP‐specific biological responses that elicit distinctive pharmacological consequences that can be harnessed for good. By limiting the scope of discussion to metallic NPs, this work attempts to provide a balanced perspective on their safety in the liver, and discusses both possible therapeutic benefits and potential accidental liver damage arising from their interaction with specific parenchymal and nonparenchymal cell types in the liver.

show abstract

“…From the tissue engineering point of view, CNPs offer prominent biological features for accelerating tissue repair and regeneration, including antioxidant, anti-inflammatory, antibacterial, angiogenic, and antiapoptotic activities [ 16 , 17 , 18 , 19 , 20 ]. There are huge numbers of experimental studies clarifying the therapeutic effectiveness of CNPs, either in bare or functionalized forms for biomedical applications [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

View full text Add to dashboard Cite

Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

show abstract

Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice

Cited by 65 publications

References 45 publications

A Comprehensive Assessment of Hepatotoxicity Induced by Engineered Nanoparticles- A Review

A Comprehensive Assessment of Hepatotoxicity Induced by Engineered Nanoparticles- A Review

All Roads Lead to the Liver: Metal Nanoparticles and Their Implications for Liver Health

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

Contact Info

Product

Resources

About