Cerium oxide nanoparticles: green synthesis and biological applications

Charbgoo, Fahimeh; Ahmad, Mansor Bin; Darroudi, Majid

doi:10.2147/ijn.s124855

Cited by 264 publications

(144 citation statements)

References 80 publications

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“…Furthermore, NPs can be functionalized to recognize specific biological targets, improving their effect; for example, triphenylphosphonium (TPP) and anti-HER2 can be used to target mitochondria [6,7] or specific tumor cells [8], respectively. Among all types of NPs proposed for biomedical applications, ceria NPs (CeO 2 ) are among the most promising due to their physicochemical properties, versatility and biocompatibility [9].…”

Section: Introductionmentioning

confidence: 99%

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

et al. 2020

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Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer’s disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (∆Ψm), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid–2–like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold.

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Section: Introductionmentioning

confidence: 99%

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

et al. 2020

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“…Among metallic nanoparticles, silver nanoparticles have strong, light, catalytic and antimicrobial properties (27,28). One of the goals of research in the field of green technology (environmentally friendly) in the field of nanoparticles synthesis is to minimize potential risks in the production process and use for humans, as well as the environment (29,30). One of these measures is finding a route to synthesize nanoparticles that decrease the potential risks and dangerous by products of synthesis and optimize the use of these nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Waste-grass-mediated green synthesis of silver nanoparticles and evaluation of their anticancer, antifungal and antibacterial activity

Khatami

Sharifi

Nobre

et al. 2018

Green Chemistry Letters and Reviews

185

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Grass waste was used for transform an inexpensive waste into health. Silver nanoparticles (AgNPs) have been synthesized using waste material (dried grass). The average size of silver nanoparticles observed in transmission electron images was estimated to be about 15 nm. The anticancer, antifungal and antibacterial effect of AgNPs were studied in vitro. The minimum inhibitory concentration of AgNPs against Pseudomonas aeruginosa and Acinetobacter baumannii was calculated about 3 µg/ml. The highest level of inhibitory effect of AgNPs against Fusarium solani was close to 90% at a concentration of 20 μg/ml of AgNPs. An inhibitory effect on the cancer cell growth is reach, by increasing the concentration of AgNPs to 5 µg/ml; the cancer cells' survival decreases about 30%. Western results showed that the expression of Cyclin D1 protein of MCF-7 cell line decreased after treatment with the effective concentration of AgNPs.

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“…Besides, green chemistry methods using extracts from plants, fruits, and fungi have also attracted increasing attention recently due to their environment-friendliness, cost-effectiveness and scalability for industrial production. Different synthesis methods and correlated toxicities are summarized in Table 1 [60,61]. As mentioned above, a lower Ce(III)/Ce(IV) ratio is correlated with higher anti-cancer and anti-bacteria efficiency.…”

Section: Synthesis Methodologymentioning

confidence: 99%

Antibacterial mechanism and activity of cerium oxide nanoparticles

et al. 2019

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Nanomaterials have been applied as antibacterial agents by virtue of their unique functioning mechanism different from that of conventional antibiotics. Cerium oxide nanoparticles (CeO 2 NPs) are important antibacterial agents due to their relatively low toxicity to normal cells and their distinct antibacterial mechanism based on the reversible conversion between two valence states of Ce(III)/ Ce(IV). Some studies have been conducted to explore their antibacterial activities; however, systematic research reviews on the related mechanisms and influencing factors are still quite rare. In this review, we discuss the plausible mechanisms of the antibacterial activity of CeO 2 NPs, analyze different influencing factors, and summarize various research reports on antibacterial effects on E. coli and S. aureus. We also propose the potential applications and prospects, and hope to provide an in-depth understanding on the antibacterial mechanism and a better guidance to the design and applications of this promising antibacterial material in the future.

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Cerium oxide nanoparticles: green synthesis and biological applications

Cited by 264 publications

References 80 publications

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

Waste-grass-mediated green synthesis of silver nanoparticles and evaluation of their anticancer, antifungal and antibacterial activity

Antibacterial mechanism and activity of cerium oxide nanoparticles

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