Certain Background Factors Exhibit an Association With an Increased Risk for Pancreatic Calcification Among Japanese Male Alcoholics

Abstract

Drinking behavior, smoking status, and genetic backgrounds are associated with PC and are likely to increase the risk for alcoholic chronic pancreatitis.

CFTR Polymorphisms in Patients with Alcoholic Chronic Pancreatitis

“…In addition, Nakamura et al [17] found that alcoholics with the (TG)12 allele had a greater risk of presenting pancreatic calcifications on helical computed tomography examination than those with the (TG)11 allele.…”

“…Other genes, such as those encoding detoxifying enzymes (alcohol dehydrogenase (ADH) [17,31] , aldehyde dehydrogenase (ALDH) [17] , glutathione S-transferase (GST) [32] and uridine 5 -diphosphate glucuronosyltransferase (AGT1A7) [33] ) and the transforming growth factor TGFbeta1 [34] might have a role, possibly with an indirect mechanism, in the genetic predisposition to alcoholic pancreatitis. However, the present results do not provide a definite conclusion.…”

Chronic pancreatitis

“…This past year, investigators reported gene polymorphisms affecting the immunological response [26][27][28][29] or endogenous/xenobiotic detoxification [30][31][32], but we do not discuss these because of recent reviews of these topics [2,33 ]. This past year, investigators reported gene polymorphisms affecting the immunological response [26][27][28][29] or endogenous/xenobiotic detoxification [30][31][32], but we do not discuss these because of recent reviews of these topics [2,33 ].…”

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

“…43,51,[83][84][85][86] Likewise, ADH1B*2 was more prevalent in people with alcoholism who had pancreatitis than those who did not have this complication in some studies but not in others. 84,[87][88][89][90][91] ADH1B has also been studied in relation to certain cancers. Again, many studies have identified ADH1B*2 as a protective factor.…”