Ceruloplasmin: Its Role in the Physiological and Pathological Processes

Orzheshkovskyi, V. V.; Trishchynska, M.A.

doi:10.1007/s11062-019-09805-9

Cited by 11 publications

(11 citation statements)

References 44 publications

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“…Indeed, the decline of plasma ceruloplasmin in the MTX group, although very modest, suggests a weakening of the inflammatory response. This is compatible with an attenuation of the systemic immune response, also in case of the release of proinflammatory cytokines, and is a known response in cases of liver failure due to trauma (Orzheshkovskyi and Trishchynska, 2019) or challenges of innate immune system. Interestingly, even if the differences were small, we found that the MTX diet altered the expression of several genes in circulating leucocytes.…”

Section: Physiological Responses Blood Variables and Gene Expressionsupporting

confidence: 63%

A mycotoxin-deactivating feed additive counteracts the adverse effects of regular levels of Fusarium mycotoxins in dairy cows

Gallo

Minuti

Bani

et al. 2020

Journal of Dairy Science

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Little is known about the effects of commonly found levels of Fusarium mycotoxins on the performance, metabolism, and immunity of dairy cattle. We investigated the effects of regular contamination levels, meaning contamination levels that can be commonly detected in dairy feeds, of deoxynivalenol (DON) and fumonisins (FB) in total mixed ration (TMR) on the performance, diet digestibility, milk quality, and plasma liver enzymes in dairy cows. This trial examined 12 lactating Holstein dairy cows using a 3-period × 3-treatment Latin Square design. The experimental period was 21 d of mycotoxin exposure followed by 14 d of washout. During treatment periods, cows received one of 3 diets: (1) CTR (control) diet of TMR contaminated with 340.5 µg of DON/kg of dry matter (DM) and 127.9 µg FB/kg of DM; (2) MTX diet of TMR contaminated with Fusarium mycotoxins at levels higher than CTR but below US and European Union guidelines (i.e., 733.0 µg of DON/kg of DM and 994.4 µg of FB/kg of DM); or (3) MDP diet, which was MTX diet supplemented with a mycotoxin deactivator product (i.e., 897.3 µg of DON/kg of DM and 1,247.1 µg of FB/kg of DM; Mycofix, 35 g/animal per day). During washout, all animals were fed the same CTR diet. Body weight, body condition score, DM intake, dietary nutrient digestibility, milk production, milk composition and rennet coagulation properties, somatic cell count, blood serum chemistry, hematology, serum immunoglobulin concentrations, and expression of multiple genes in circulating leucocytes were measured. Milk production was significantly greater in the CTR group (37.73 kg/d) than in the MTX (36.39 kg/d) and the MDP (36.55 kg/d) groups. Curd firmness and curd firming time were negatively affected by the MTX diet compared with the other 2 diets. Furthermore, DM and neutral detergent fiber digestibility were lower after the MTX diet than after the CTR diet (67.3 vs. 71.0% and 42.8 vs. 52.3%). The MDP diet had the highest digestibility coefficients for DM (72.4%) and neutral detergent fiber (53.6%) compared with the other 2 diets. The activities of plasma liver transaminases were higher after the MTX diet than after the CTR and MDP diets. Compared with the CTR diet, the MTX diet led to slightly lower expression of genes related to immune and inflammatory functions, indicating that Fusarium mycotoxins had an immunosuppressive effect. Our results indicated that feed contaminated with regular levels of Fusarium mycotoxins adversely affected the performance, milk quality, diet digestibility, metabolic variables, and immunity of dairy cows, and that supplementation with mycotoxin deactivator product counteracted most of these negative effects.

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Section: Physiological Responses Blood Variables and Gene Expressionsupporting

confidence: 63%

A mycotoxin-deactivating feed additive counteracts the adverse effects of regular levels of Fusarium mycotoxins in dairy cows

Gallo

Minuti

Bani

et al. 2020

Journal of Dairy Science

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“…In the reactome, the enriched pathways were identified and in IPA, based on the expression of the DEGs the activated/inactivated/not-activated pathways were identified. In reactome, on functionally annotating the DEGs of each of the genetic groups, key pathways related to stress – neutrophil degranulation 42 , L13a-mediated translational silencing of ceruloplasmin expression 43 , ubiquitination and proteasome degradation 44 , SRP-dependent cotranslational protein targeting to membrane 45 , Nonsense-Mediated Decay 46 and selenocysteine synthesis 47 were enriched in both the genetic groups. Among the common genes, the genes upregulated in Tharparkar but downregulated in Vrindavani showed enrichment towards cellular response to stress besides the above-mentioned pathways.…”

Section: Discussionmentioning

confidence: 99%

Systems Biology under heat stress in Indian Cattle

Khan

Sahu

Malla

et al. 2020

Preprint

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BackgroundHeat stress induced by high environmental temperature and humidity affects livestock production and health. With global warming on the uprise, indigenous cattle known for their heat tolerance are gaining importance than the crossbreds. However, systems biology behind this phenotype in indigenous cattle is less known. In this study using transcriptome analysis, we identified key molecules and pathways that may lead to the heat tolerance phenotype in indigenous cattle (Tharparkar breed) Results

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“…Additionally, CP is an acute phase protein, rising rapidly in inflammation [ 78 ]. It has been found to have a role in Wilson’s disease, as well as neurodegenerative, demyelinating and cardiovascular disease [ 79 ]. Animal models have demonstrated a renal protective role of CP as its absence resulted in iron deposition in the renal medulla and cortex, structural renal abnormalities and subsequent proteinuria [ 80 ].…”

Section: Renal Biomarkersmentioning

confidence: 99%

Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus

Greenan-Barrett

Doolan

Shah

et al. 2021

IJMS

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Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.

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Ceruloplasmin: Its Role in the Physiological and Pathological Processes

Cited by 11 publications

References 44 publications

A mycotoxin-deactivating feed additive counteracts the adverse effects of regular levels of Fusarium mycotoxins in dairy cows

A mycotoxin-deactivating feed additive counteracts the adverse effects of regular levels of Fusarium mycotoxins in dairy cows

Systems Biology under heat stress in Indian Cattle

Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus

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