Cervical and oral human papillomavirus types in HIV‐1 positive and negative women with cervical disease in South Africa

Marais, Dianne J.; Passmore, Jo‐Ann S.; Denny, Lynette; Sampson, Candice; Allan, Bruce; Williamson, Anna‐Lise

doi:10.1002/jmv.21166

Cited by 61 publications

(52 citation statements)

References 20 publications

(33 reference statements)

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“…Today, it is clear that a woman can harbour multiple HPV infections with different oncogenic types. 25,26 Conclusion HPV infections were highly prevalent in this study of women without cervical cytological abnormalities. The most prevalent HPV types were HPV 62, 84 and 16.…”

Section: Infection With Multiple Human Papillomavirus Typesmentioning

confidence: 69%

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Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study

Aardt

Dreyer

Richter

et al. 2013

Southern African Journal of Gynaecological Oncology

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Objectives: Knowledge of human papillomavirus (HPV) distribution in the general population is crucial for the development of new HPV vaccines and to provide a baseline from which to monitor the impact of current HPV vaccines in the future. HPV-type distribution in the Tshwane area, South Africa, might be different to that in other regions and countries. Design: This was a retrospective descriptive study, representative of women without cervical cytological abnormalities. Setting and subjects: Women attending primary health clinics in the region of Tshwane were screened for cervical abnormalities with conventional cytology. Outcome measures: Women without cytological abnormalities were included, and HPV DNA typing, using HPV Linear® Array Genotyping Test (Roche Molecular Systems, Branchburg, USA) was performed on all women. Results: Demographic data were available for 1 238 patients. The mean age was 40.9 years. The majority of the women (14.6%) were between 35 and 39 years of age. 19.4% of women were younger than 30 years of age. The prevalence of HPV types was 67.1% and high-risk HPV infections, 44.9%. The average number of HPV-type infections was 3.2 in the 845 patients with HPV infections. The most common high-risk virus was HPV 16 (10.8%), followed by HPV 51 (9.3%), and HPV 58 (7.9%). HPV 18 was observed in 5.9%, and HPV 45 in 7.5%, of participants. HPV 62 (15.6%) and HPV 84 (14.4%) were the most prevalent low-risk types. Conclusion: HPV infections were highly prevalent in this population. The prevalence of HPV 16 and 18 was higher than that reported in other world regions. HPV 16 was the most prevalent high-risk type infection in women without cytological abnormalities. HPV infections other than HPV 16 and 18 were also prevalent, and this is important for future vaccine development.Peer reviewed.

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Section: Infection With Multiple Human Papillomavirus Typesmentioning

confidence: 69%

“…25,26 There has been a rise from 4% to 15.7% in multiple HPV infections found in cervical cancer in the past 20 years. 25 However, from the results of one study, it did not seem as if multiple HPV infections had an influence on the natural history of one another.…”

Section: Infection With Multiple Human Papillomavirus Typesmentioning

confidence: 99%

Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study

Aardt

Dreyer

Richter

et al. 2013

Southern African Journal of Gynaecological Oncology

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“…Known risk factors for oral and oropharyngeal HPV infection currently include lifetime number of sexual partners, [6,9,11] number of oral sex partners, [1,12] substance use [9,[12][13][14] and infection with HIV. [15][16][17][18] Sexual contact, either genital or oral, remains the primary mode of HPV transmission, and it is well documented that having multiple partners increases the prevalence of oral and genital HPV. [6,9,19,20] A study in KwaZulu-Natal, SA, reported male undergraduate students to have had a median of four sexual partners in the previous year.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: A pilot study

et al. 2014

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Background. Human papillomavirus (HPV) infection is well known to be associated with head and neck cancers (HNCs). HPV-associated HNCs are related to sexual behaviour, particularly the lifetime number of oral sex partners, but the epidemiology of oral and oropharyngeal HPV in South African men has not yet been studied. Objectives. To determine the oral and oropharyngeal HPV strain prevalence and associated factors in a selected male population in Pretoria, South Africa (SA). Methods. Male factory workers were recruited. Oral rinse and gargle samples were tested for 37 HPV types using the Linear Array HPV Genotyping Test (Roche Molecular Systems). A questionnaire was used to obtain information regarding age, medical conditions, substance and alcohol use and sexual behaviour. HIV testing was optional. Results. The HPV prevalence was 5.6% among men (N=125) aged 17 -64 years. High-risk HPV (hrHPV) types 16 and 68 were found in two men. Oral sex seemed to be an uncommon practice in the majority of respondents, but the two respondents with hrHPV did practise oral sex. There was a statistically significant association between HPV infection and an increased number of sexual partners (p=0.027), but not between HPV and substance use, HIV status or clinical mucosal pathology. Conclusion. The prevalence of oral and oropharyngeal HPV was lower than reported in other countries. An association between oral HPV and having multiple sexual partners was found. A larger nationwide study would give a more representative view of the burden of oral and oropharyngeal HPV infection in SA.

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“…Alguns autores demonstraram que, em comparação com as soronegativas, as mulheres HIV soropositivas são, aproximadamente, quatro vezes mais propensas a serem infectadas pelo HPV e cinco vezes mais a desenvolver CIN, além de lesões em múltiplos sítios, como vagina, vulva e região perianal (1,8,10,15) . Em nosso estudo, 19 (58%) em 33 lesões de colo uterino do grupo A correspondiam a CIN, o que demonstra frequência média maior do que a da literatura.…”

Section: Discussionunclassified

“…Torna-se relevante identificar a infecção epitelial genital pelo EBV, bem como a possível coinfecção com o HPV, principal agente associado ao desenvolvimento de lesões intraepiteliais e carcinomas escamosos genitais (17,19) . O imunocomprometimento relacionado com o vírus da imunodeficiência humana do tipo 1 (HIV-1) é sabidamente um fator de aumento do risco para a carcinogênese genital, assim, torna-se relevante verificar possíveis diferenças entre os pacientes (13,15) . Partindo desses pressupostos, os objetivos deste estudo foram verificar a frequência de imunopositividade para a LMP1 e do antígeno comum do HPV em lesões genitais provenientes de pacientes infectados ou não pelo HIV-1 e correlacionar a imunopositividade com o local e o diagnós-tico histopatológico das lesões.…”

Section: Investigation Of the Lmp1 Ebv And Co-infection By Hpv In Genunclassified

Investigação da LMP1 do EBV e a coinfeçcão do HPV em lesões genitais de pacientes infectados ou não pelo HIV

Rodrigues¹,

Miranda²,

Fonseca³

et al. 2010

J. Bras. Patol. Med. Lab.

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Introdução: Vários estudos têm demonstrado associação do vírus Epstein-Barr (EBV) com neoplasias malignas, inclusive genitais, em que o papilomavírus humano (HPV) é o principal vírus associado às neoplasias epiteliais benignas e malignas. Objetivo: Investigar a presença do EBV e do HPV em lesões genitais de ambos os sexos, em pacientes soropositivos (grupo A) ou não (grupo B) para o vírus da imunodeficiência humana (HIV). Material e método: Selecionados 126 pacientes e 135 lesões anogenitais, sendo 67 pacientes (53%) e 75 lesões (56%) no grupo A e 59 pacientes (47%) e 60 lesões (44%) no grupo B, para análise imuno-histoquímica (IHQ) por meio dos anticorpos monoclonais antiproteína latente de membrana 1 (LMP1) e HPV (DAKO ® ). Resultados: A análise mostrou que o número total de lesões com imunopositividade para o HPV e para a LMP1 foi maior no grupo A (32 e 35, respectivamente) quando comparado ao B (16 e seis, respectivamente). A análise estatística (nível de significância de 5%) mostrou que as proporções para o HPV não são estatisticamente significativas (z = 1,93; valor p = 0,053). Entretanto, para a LMP1, a diferença (47% no grupo A e 10% no B) é significativa (z = 4,60; valor p = 4,2×10-6). Do mesmo modo, a associação HPV-LMP1 (21% no grupo A e 7% no B) também mostrou diferença estatisticamente significativa (z = 2,38; valor p = 0,017). Conclusão: Esses resultados indicam a possibilidade de sinergismo da infecção pelo EBV e a coinfecção EBV-HPV em lesões epiteliais genitais, particularmente em pacientes soropositivos para o HIV. Entretanto, investigações com metodologia de maior especificidade e sensibilidade são necessárias para a verificação da real participação do EBV na patogênese de lesões epiteliais genitais.

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Cervical and oral human papillomavirus types in HIV‐1 positive and negative women with cervical disease in South Africa

Cited by 61 publications

References 20 publications

Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study

Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study

Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: A pilot study

Investigação da LMP1 do EBV e a coinfeçcão do HPV em lesões genitais de pacientes infectados ou não pelo HIV

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