Cervical Cancer Cells Express Markers Associated with Immunosurveillance

Gutiérrez‐Hoya, Adriana; Zerecero‐Carreón, Octavio; Valle‐Mendiola, Arturo; Moreno-Lafont, Martha; López‐Santiago, Rubén; Weiss‐Steider, Benny; Soto‐Cruz, Isabel

doi:10.1155/2019/1242979

Cited by 23 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…34,36 In line with this suggestion, the levels of HCP5 were signifi- receptors on their own surface. 30,31,[37][38][39] It is possible that one mechanism by which rs2844511 could modify cervical cancer risk is the regulation of MICA expression and subsequent immune-surveillance of tumor cells. From the results of our study, the risk allele of rs2844511 associated with increased MICA levels in HPV negative (normal) cervical epithelium, but this was reversed in HPV infected cells.…”

Section: Discussionmentioning

confidence: 99%

“…Little surface expression of MICA is seen in healthy cells; however, most epithelial tumor cells express MICA. There are multiple modes through which cervical cancer cells evolve to evade this detection, including the secretion of MICA in a soluble form to block NKG2D receptors or the aberrant expression of NKG2D receptors on their own surface 30,31,37‐39 . It is possible that one mechanism by which rs2844511 could modify cervical cancer risk is the regulation of MICA expression and subsequent immune‐surveillance of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

Ramachandran

Schürmann

Mao

et al. 2020

Intl Journal of Cancer

View full text Add to dashboard Cite

The human leukocyte antigen (HLA) locus on chromosome 6 has been reported to be associated with cervical cancer. We investigated two independent single‐nucleotide polymorphisms in a large case‐control series of cervical dysplasia and carcinoma that has been newly established by the German Cervigen Consortium, comprising a total of 2481 cases and 1556 healthy females. We find significant associations for both variants, rs9272117 at HLA‐DQA1 and rs2844511 at MICA and HCP5, with cervical disease. Both variants showed evidence of association with invasive cervical cancer (rs9272117: OR 0.89, 95% CI 0.79‐0.99, P = .036; rs2844511: OR 1.17, 95% CI 1.04‐1.31, P = .008) and with high‐grade dysplasia (rs9272117: OR 0.78, 95% CI 0.70‐0.87, P = 7.1 × 10−6; rs2844511: OR 1.13, 95% CI 1.01‐1.26, P = .035), as well as in a combined analysis of both groups (rs9272117: OR 0.83, 95% CI 0.75‐0.91, P = 6.9 × 10−5; rs2844511: OR 1.14, 95% CI 1.04‐1.26, P = .005). Variant rs2844511, but not rs9272117, also showed modest evidence of association with low‐grade dysplasia (OR 1.26, 95% CI 1.04‐1.54, P = .019). In case‐only analyses, rs2844511 tended to predict HPV status (P = .044) and rs9272117 tended to associate with HPV16 (P = .022). RNA studies in cervical samples showed a significant correlation in the transcript levels of MICA, HCP5 and HLA‐DQA1, suggesting extensive co‐regulation. All three genes were upregulated in HPV16‐positive samples. In stratified analyses, rs9272117 was associated with HLA‐DQA1 levels, specifically in HPV‐positive samples, while rs2844511 was associated with MICA and HCP5 levels. The risk allele of rs2844511 was required for correlations between MICA or HCP5 with HLA‐DQA1. Altogether, our results support 6p21.32‐33 as the first consistent cervical cancer susceptibility locus and provide evidence for a link between genetic risk variants, HPV16 status and transcript levels of HLA‐DQA1, HCP5 and MICA, which may contribute to tumor immune evasion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

Ramachandran

Schürmann

Mao

et al. 2020

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…For example, our group demonstrated that cervical tumour cells express NK cells markers such as NKG2D, NKG2A, NKp30, NKp46 mainly. However, we do not know why cervical cancer cells express these molecules and the benefit they bring to tumour cells regarding NK cells activity (Figure 3) [35,[53][54][55][56][57][58][59][60][61][62].…”

Section: Modulation Of the Nk Cells Response In Cervical Cancermentioning

confidence: 99%

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Gutiérrez‐Hoya

Soto‐Cruz²

2021

Cells

Self Cite

View full text Add to dashboard Cite

Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus-infected cells and tumours through a delicate balance between activating and inhibitory receptors and secretion of cytokines and chemokines. These cells also play a crucial role in tumour immunosurveillance. For these reasons, there is growing interest in harnessing NK cells as an immunotherapy for cervical cancer. These studies are diverse and include many strategies such as transferring activated autologous or allogeneic NK cells, improving the activation and cytolytic activity of NK cells using cytokines or analogues and modifying chimeric antigen receptors to increase specificity and targeting NK cells. However, research regarding the application of NK cells in immunotherapy is limited. This article focuses on recent discoveries about using NK cells to prevent and treat cervical cancer and the possibility of cellular immunotherapy becoming one of the best strategies to exploit the immune system to fight tumours.

show abstract

“…These were as follows: (a) MICA/B and CD95 (involved in tumour cell recognition); (b) CD39, CD73, CTLA‐4 (immune system escape); and (c) NKp30, NKp46, NKG2A and KIR3DL1 (typical markers of NK cells like). The authors concluded that these molecules might allow the CCLs to mimic the immune system 71 …”

Section: Cervical Cancer and Its Cell Linesmentioning

confidence: 99%

Gynaecological cancers and their cell lines

Skok

Gradišnik

Maver

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

Cell lines are widely used for various research purposes including cancer and drug research. Recently, there have been studies that pointed to discrepancies in the literature and usage of cell lines. That is why we have prepared a comprehensive overview of the most common gynaecological cancer cell lines, their literature, a list of currently available cell lines, and new findings compared with the original studies. A literature review was conducted via MEDLINE, PubMed and ScienceDirect for reviews in the last 5 years to identify research and other studies related to gynaecological cancer cell lines. We present an overview of the current literature with reference to the original studies and pointed to certain inconsistencies in the literature. The adherence to culturing rulesets and the international guidelines helps in minimizing replication failure between institutions. Evidence from the latest research suggests that despite certain drawbacks, variations of cancer cell lines can also be useful in regard to a more diverse genomic landscape.

show abstract

Cervical Cancer Cells Express Markers Associated with Immunosurveillance

Cited by 23 publications

References 37 publications

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Gynaecological cancers and their cell lines

Contact Info

Product

Resources

About