Cervical cancer screening in rural India

Srivastava, Anand; Misra, JS; Srivastava, Shruti; Das, Bina Pani; Gupta, Shilpi

doi:10.4103/ijmr.ijmr_5_17

Cited by 113 publications

(89 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Every year India reports more than one lakh new cervical cancer cases and is home to 16% of cervical cancer cases occurring globally. 2 Unlike the multifactorial etiology of many cancers, the established causal role of infection by human papillomavirus (HPV) in cancer cervix uteri has resulted in the development of more sensitive HPV-based screening assays for secondary prevention and prophylactic vaccines against HPV for primary prevention. An association with HPV has been reported in 83.2% invasive cervical cancers occurring in India.…”

Section: Introductionmentioning

confidence: 99%

Comparison of two self‐sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates

Kuriakose

Sabeena

Ravishankar

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

One major advantage of molecular assays for human papillomavirus (HPV) DNA detection is that these assays can be performed on self‐collected samples unlike cytology or visual inspection with acetic acid (VIA). This cross‐sectional study was carried out between March 2017 and April 2019 to compare the diagnostic performance in self‐collected urine and vaginal samples for HPV DNA detection. Viral DNA was extracted from processed samples using a Qiagen viral DNA extraction Kit (QIAamp DNA Mini Kit). To detect four common high‐risk HPV types (16, 18, 31, 45), multiplex real‐time polymerase chain reaction (PCR) targeting the LCR/E6/E7 region of the HPV genome was performed in ABI 7500 cycler (Applied Biosystems). The negative samples were screened by conventional PCR targeting the L1 capsid region to exclude other HPV types. The overall agreement between the two self‐collecting sampling methods was 64.04% with a κ value of 0.29 pointing towards a fair agreement (P < .01). The sensitivity of HPV DNA detection in urine samples was 57.95% (47.52%, 67.72), and specificity was 84.6% (66.47%, 93.85%) when compared with vaginal samples. The study concludes that self‐collected vaginal HPV DNA testing is more sensitive than unpreserved‐urine samples for HPV DNA detection in a hospital‐based setting.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of two self‐sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates

Kuriakose

Sabeena

Ravishankar

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Educational model-based interventions promote self-care and create a foundation for improving the acceptance for cancer screening. [11][12][13][14] Screening policies should take into consideration socio-economic factors, which influence disease causation. 15 The introduction of innovative methods for screening of large population should be emphasized.…”

Section: Discussionmentioning

confidence: 99%

Screening for non-communicable diseases

Christe

Vijaya²,

Tharangini³

2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: This study was conducted to enumerate the results of screening for non-communicable diseases in the NCD clinic over a period of one year in a tertiary health centre.Methods: The results from screening tests conducted in the NCD clinic, for detecting hypertension, diabetes mellitus, breast cancer and cervical cancer, in Government tertiary care Hospital for Women, Chennai, were recorded. The flowchart and screening methods followed were those recommended by the NHM - NPCDCS. Data thus obtained was analyzed using standard statistical methods.Results: Of 42,519 women screened for common non communicable diseases - hypertension, diabetes mellitus, breast cancer and cervical cancer, nearly 5.55% women (n = 2359) had positive results, for any one of the diseases screened. Of 11,708 women screened for diabetes mellitus and 13,971 screened for hypertension, positive results were found in 856 women and 1,216 women respectively. Around 7,568 women were screened for cervical cancer and 175 women tested positive. A large number of 9,272 women were screened for breast cancer and 112 women had positive results. As per the guidelines, women who tested positive for screening tests were referred to the concerned departments in RGGGH.Conclusions: Nearly 42,519 women were screened for common non-communicable diseases (NCDs) - hypertension, diabetes mellitus, breast cancer and cervical cancer, and 5.55% women had positive test results for any one of the diseases screened. The screening revealed, 8.7% of women had raised blood pressure, 7.31% had raised blood sugar levels, 1.21% women had positive screening test results for breast cancer, and 2.31% women for cervical cancer.

show abstract

“…Cervical cancer is the third most common malignant tumor of the female reproductive tract and the fourth largest cause of cancer-related death worldwide [1,2]. Most patients already have progressive disease at the time of treatment, and many treatment methods have not achieved satisfactory results [3,4]. Presently, the mechanisms of proliferation, invasiveness and metastasis of cervical cancer have not been fully clarified [5].…”

Section: Introductionmentioning

confidence: 99%

LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT

Dai

Lin

et al. 2020

J. Cancer

View full text Add to dashboard Cite

Objective: To explore the relationship and mechanism of LZAP in the occurrence and development of cervical cancer and to provide a new target and intervention method for the treatment of cervical cancer. Methods: Data mining and analysis of LZAP expression levels were performed using several online databases, including The Cancer Genome Atlas (TCGA). A cervical cancer cell line that stably overexpresses LZAP was established, and the effect of LZAP overexpression on cell proliferation, invasion, migration and tumor formation in vivo as well as its mechanism were explored. Results: Our study shows that the expression of LZAP is upregulated in cervical cancer. The overexpression of LZAP can significantly promote the proliferation, colony formation, and invasion and migration abilities of cervical cancer cells. The tumorigenesis test in nude mice showed that overexpression of LZAP could promote the tumorigenicity of cervical cancer cells in vivo. LZAP could also promote the phosphorylation of AKT at position 473 and the epithelial-mesenchymal transition (EMT). Conclusion: The expression of LAZP is increased in cervical cancer, which can enhance the invasion, metastasis, and EMT in cervical cancer cells by promoting AKT phosphorylation.

show abstract

Cervical cancer screening in rural India

Cited by 113 publications

References 38 publications

Comparison of two self‐sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates

Comparison of two self‐sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates

Screening for non-communicable diseases

LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT

Contact Info

Product

Resources

About