Cervical cancer screening program based on HPV testing and conventional Papanicolaou cytology for jail inmates

Fabiano, Vincenza; Mariani, Luciano; Giovagnoli, Maria Rosaria; Raffa, Salvatore; Vincenzoni, Cristina; Michetti, Fausto de; Bevere, Francesco; French, Deborah

doi:10.4236/health.2010.29151

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…There is a paucity of data in HPV testing among incarcerated women in low resource countries. Most studies describing the epidemiology of hr-HPV infection among incarcerated women have emanated from relatively higher-income settings [10][11][12][13][14][15][16]. In lower income settings, studies have been done using non-routine clinical approaches [10,12,14,15].…”

Section: Introductionmentioning

confidence: 99%

Determining the prevalence of high-risk human papillomavirus infection using a novel cervical precancer screening approach in incarcerated women at the Nsawam Medium Security Prison, Ghana

Acheampong¹,

Effah²,

Amuah³

et al. 2021

ecancer

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Background: Across Ghana, females comprise 1.2% of the entire prison population (n = 15,463). Cervical cancer screening services are however nonexistent and the prevalence of high-risk human papillomavirus (hr-HPV) and cervical precancer is undocumented. We aimed to screen and treat inmates for cervical precancer and determine the prevalence of hr-HPV using the novel AmpFire HPV detection system combined with colposcopy by trained nurses using a mobile colposcope (the Enhanced Visual Assessment (EVA) system). Methods:A descriptive cross-sectional study design was employed, involving all incarcerated women at the Nsawam Medium Security Prison, Ghana. After counselling and informed consent, women underwent a structured questionnaire-based interview entered into a Microsoft Excel spreadsheet. Women were co-tested for cervical precancer and hr-HPV by two trained nurses using dry brush cervical samples for 15 hr-HPV types (AmpFire HPV test) after which mobile colposcopy with the EVA system was performed. EVA images were reviewed by a gynaecologist. Frequencies and percentages were used to describe categorical data, while means, standard deviations, medians and interquartile ranges (IQRs) were used to describe continuous data.Results: 75% of the women were convicts with a median sentence of 5 years (IQR: 2-10 years). Their mean age was 41.1 years (standard deviation: 15.5 years, range: 19-97 years). The self-reported prevalence rate of HIV was 13.1% (95% confidence interval (CI): 7.5%-21.9%), all of whom were receiving treatment. The hr-HPV prevalence rate was 47.6% (CI: 36.9%-58.3%) in the general population of imprisoned women and 63.6% (CI: 35.4%-84.8%) among HIV positive women. Six percent (6%) had lesions on the cervix, of which 3.6% were treated with thermal coagulation and 2.4% were treated with loop electrosurgical excision procedure. The average age of hr-HPV positive women was 37.8 years. Research

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Section: Introductionmentioning

confidence: 99%

Determining the prevalence of high-risk human papillomavirus infection using a novel cervical precancer screening approach in incarcerated women at the Nsawam Medium Security Prison, Ghana

Acheampong¹,

Effah²,

Amuah³

et al. 2021

ecancer

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“…The range of publication dates was wide with studies performed between 1968 and 2017. Included studies were from USA,25–37 Canada,38–42 UK,43–47 Spain,48 49 Italy,50 Brazil,51–54 Peru,55 Mexico,56 57 Taiwan58 and Russia 59. All studies had a cross-sectional design and only nine included a comparison group.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies reported the prevalence of HPV genital infection in imprisoned women using molecular detection methods 28 48–50 52 53 58 59. None of these studies had a comparison group, and there were no available data from national screening programmes.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer in imprisoned women worldwide: a systematic review and meta-analysis

Escobar

Plugge

2019

J Epidemiol Community Health

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Background and objectivesImprisoned women have higher rates of abnormalities at cervical screening and some studies suggest that cervical cancer is the most common cancer in this population. The aim of this work was to summarise the current evidence on the prevalence of human papilloma virus (HPV) infection, cervical cancer and precancerous lesions in women in prison worldwide and to compare these rates with the general population.MethodsWe systematically searched and reviewed published and unpublished data reporting the prevalence of any HPV infection, cervical intraepithelial neoplasia (CIN) and cervical cancer in imprisoned women. We created forest plots with prevalence estimates from studies with comparable outcomes and of prevalence ratios using data from national screening programmes as a comparison group.FindingsA total of 53 533 imprisoned women from 10 countries and 35 studies were included in the review. The prevalence of HPV among prisoners ranged from 10.5% to 55.4% with significant heterogeneity. The prevalence of CIN diagnosed by cytology in prisoners ranged from 0% to 22%. Ratios comparing the prevalence of CIN in imprisoned women to that in the community ranged from 1.13 to 5.46. Cancer prevalence estimates were at least 100 times higher than in populations participating in national screening programmes.ConclusionImprisoned women are at higher risk of cervical cancer than the general population. There is a high prevalence of HPV infection and precancerous lesions in this population. Targeted programmes for control of risk factors and the development of more effective cervical screening programmes are recommended.PROSPERO registration numberCRD42014009690.

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“…The estimated 470000 new cases of infection and about 230000 deaths per year represents a global challenge, especially in under-developed countries, where cervical cancer is the leading cause of death from cancer ( 2 ). It is believed that infection with human papillomaviruses (HPVs) is necessary for development of cervical cancer ( 3 ). This infection, which is one of the most common Sexually Transmitted Infections (STIs) worldwide ( 4 ), not only contributes to the etiology of cervical cancer, especially in the case of high-risk HPV types (HPV 16, 18, 31, 33, etc.…”

Section: Introductionmentioning

confidence: 99%

Detection and Typing of Human Papilloma Viruses by Nested Multiplex Polymerase Chain Reaction Assay in Cervical Cancer

Kiani

Malekshahi

Ghalejoogh

et al. 2015

Jundishapur J Microbiol

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Background:Cervical cancer is the leading cause of death from cancer in under-developed countries. Human papilloma virus (HPV) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. Conventional Polymerase Chain Reaction (PCR), type-specific and consensus primer-based PCR followed by sequencing, Restriction Fragment Length Polymorphism (RFLP) or hybridization by specific probes are common methods for HPV detection and typing. In addition, some researchers have developed a multiplex PCR for simultaneous detection and typing of different HPVs.Objectives:The aim of the present study was to investigate the prevalence of HPV infection and its types in cervical Squamous Cell Carcinoma (SCC) using the Nested Multiplex PCR (NMPCR) assay.Patients and Methods:Sixty-six samples with histologically confirmed SCC were evaluated. Total DNA was isolated by phenol–chloroform extraction and ethanol precipitation. Nested multiplex PCR was performed with first-round PCR by GP-E6/E7 consensus primers for amplification of the genomic DNA of all known mucosal HPV genotypes and second-round PCR by type-specific multiplex PCR primer cocktails.Results:Human papilloma virus infection was detected in 78.8% of samples, with the highest prevalence of HPV 16 (60.6%) while concurrent infections with two types was detected in 10.6%.Conclusions:The NMPCR assay is more convenient and easy for analysis of results, which is important for fast diagnosis and patient management, in a type-specific manner.

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Cervical cancer screening program based on HPV testing and conventional Papanicolaou cytology for jail inmates

Abstract: ABSTRACT

Cited by 4 publications

References 26 publications

Determining the prevalence of high-risk human papillomavirus infection using a novel cervical precancer screening approach in incarcerated women at the Nsawam Medium Security Prison, Ghana

Determining the prevalence of high-risk human papillomavirus infection using a novel cervical precancer screening approach in incarcerated women at the Nsawam Medium Security Prison, Ghana

Prevalence of human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer in imprisoned women worldwide: a systematic review and meta-analysis

Detection and Typing of Human Papilloma Viruses by Nested Multiplex Polymerase Chain Reaction Assay in Cervical Cancer

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