Cervical carcinomas with a micropapillary component: a clinicopathological study of eight cases

Abstract

Usual-type (HPV-related) cervical carcinomas may show micropapillary differentiation, usually as a focal finding, and the cells show reverse polarity like similar tumours arising in other sites. Micropapillary cervical carcinoma appears to be a clinically aggressive malignancy, although this needs to be confirmed in larger studies.

Invasive Micropapillary Carcinoma of the Uterine Cervix

“…Irrespective of location, the presence of a micropapillary component has been documented as one of the most important factors that determines clinical behavior and outcome [9, 10]. In agreement with reports that a micropapillary pattern is associated with an aggressive clinical course of adenocarcinoma in many different organs, IMPC of the uterine cervix has been reported to frequently exhibit extensive LVI and be classified as an advanced stage at the time of diagnosis [2, 5, 7]. In a recent case series of 44 cervical IMPCs reported by Alvarado-Cabrero et al [7], LVI was detected in all cases (100.0%), and lymph node metastases were present in 41 of the 44 cases (93.2%).…”

“…The term invasive micropapillary carcinoma (IMPC) was first proposed by Siriaunkgul and Tavassoli [1] in the breast. IMPC is a rare variant of adenocarcinoma, exhibiting a distinct morphological pattern that consists of small, morula-like nests of malignant tumor cells typically lacking central fibrovascular support, with surrounding clear cleft-like or lacunar stromal spaces [2, 3]. These characteristic morphological features were subsequently identified in carcinomas of other organs, such as the salivary gland, thyroid, lung, gastrointestinal tract, pancreatobiliary tract, urinary bladder, and ovary, and the IMPC terminology was applied to those tumors.…”

“…IMPC of the uterine cervix is a very rare condition. To the best of our knowledge, only 55 cases of uterine cervical IMPC have been documented in the English literature [2, 4-7]. Alvarado-Cabrero et al [7] recently reported the largest case series of 44 cervical IMPCs.…”

“…Alvarado-Cabrero et al [7] recently reported the largest case series of 44 cervical IMPCs. Stewart et al [2] reported the results of the clinicopathological analysis of 8 IMPCs. Each of the remaining 3 cases was published as an individual case report [4-6].…”

Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes

“…72 Even micropapillary growth pattern of cervical adenocarcinoma that can mimic peritoneal serous carcinoma has been described, usually associated with a compo-nent of UEA and harboring HPV (Figure 8, A through C). [73][74][75][76][77] The evidence suggests that ''serous carcinoma'' of the cervix most likely represents a high-grade variant of HPVassociated UEA with ''serous-like'' features and that a certain proportion of so-called cervical serous carcinomas are likely drop metastases from the adnexa (assuming there is no endometrial lesion). If one is considering the diagnosis of primary endocervical serous carcinoma, metastases from the uterine corpus and adnexa, including occult tubal primary lesions, must be rigorously excluded.…”