Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes

Kacerovský, Marian; Musilová, Ivana; Jacobsson, Bo; Drahosova, Marcela; Hornychová, Helena; Janků, Petr; Procházka, Martin; Šimetka, Ondřej; Andrýs, Ctirad

doi:10.3109/14767058.2014.908179

Cited by 38 publications

(37 citation statements)

References 27 publications

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“…Spontaneous miscarriages have also been found to be associated with higher first and second trimester IL‐6 levels, showing an increased rate of miscarriages in pregnant women with IL‐6 levels above 1.725 pg/mL . Additionally, consistent with our results, previous studies have shown a relationship between PPROM and increased IL‐6 levels in maternal serum and cervicovaginal fluid during 24‐37 th weeks of gestation, as well as increased IL‐6 levels in the serum of IUGR neonates when compared with controls …”

Section: Discussionsupporting

confidence: 91%

“…suggested that IL‐6 might be a crucial factor in the maternal host response as a result of significantly higher levels of IL‐6 in patients with second trimester abortion . As systemic inflammation has been proposed to be responsible for preterm delivery (PTD) and the preterm premature rupture of membranes (PPROM), various cytokines, including IL‐6, have been already studied in different specimens, such as maternal plasma/serum, cervicovaginal and amniotic fluid, and has been found to be both associated and predictive for these adverse pregnancy outcomes . In autoimmune diseases, including Grave's disease, the role of antibodies is known to be T‐cell mediated .…”

Section: Introductionmentioning

confidence: 99%

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First trimester interleukin‐6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients

Öztaş

Erkenekli

Özler

et al. 2015

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

First trimester interleukin‐6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients

Öztaş

Erkenekli

Özler

et al. 2015

J of Obstet and Gynaecol

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“…Microorganisms may gain access to the amniotic cavity in patients with intact membranes, and induce an inflammatory response leading to the production of cytokines [73,75,76,81, [89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107], chemokines [108][109][110][111][112][113][114], other inflammatory mediators [115][116][117][118][119][120][121][122][123][124], and thrombin [125][126][127][128][129][130]. Microorganisms and their products can also induce the production of matrix degrading enzymes [65,[131][132][133][134][135]…”

Section: The Importance Of Microbial Invasion Of the Amniotic Cavity mentioning

confidence: 99%

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

Romero

Miranda

Chaemsaithong

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

367

294

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Objective The objectives of this study were to: 1) determine the amniotic fluid (AF) microbiology of patients with preterm prelabor rupture of membranes (PROM); and 2) examine the relationship between intra-amniotic inflammation with and without microorganisms (sterile inflammation) and adverse pregnancy outcomes in patients with preterm PROM. Methods AF samples obtained from 59 women with preterm PROM were analyzed using cultivation techniques (for aerobic and anaerobic bacteria as well as genital mycoplasmas) and with broad-range polymerase chain reaction coupled with electrospray ionization mass spectrometry (PCR/ESI-MS). AF concentration of interleukin-6 (IL-6) was determined using ELISA. Results of both tests were correlated with AF IL-6 concentrations, and the occurrence of adverse obstetrical/perinatal outcomes. Results 1) PCR/ESI-MS, AF culture, and the combination of these two tests, each identified microorganisms in 36% (21/59), 24% (14/59) and 41% (24/59) of women with preterm PROM, respectively; 2) the most frequent microorganisms found in the amniotic cavity were Sneathia species and Ureaplasma urealyticum; 3) the frequency of microbial-associated and sterile intra-amniotic inflammation was overall similar [ 29% (17/59)]: - however, the prevalence of each differed according to the gestational age when PROM occurred ; 4) the earlier the gestational age at preterm PROM, the higher the frequency of both microbial-associated and sterile intra-amniotic inflammation; 5) the intensity of the intra-amniotic inflammatory response against microorganisms is stronger when preterm PROM occurs early in pregnancy; and 6) the frequency of acute placental inflammation (histologic chorioamnionitis and/or funisitis) was significantly higher in patients with microbial-associated intra-amniotic inflammation than in those without intra-amniotic inflammation [93.3% (14/15) vs. 38% (6/16); p=0.001]. Conclusions 1) The frequency of microorganisms in preterm PROM is 40% using both cultivation and PCR/ESI-MS; 2) PCR/ESI-MS identified microorganisms in the AF of 50% more women with preterm PROM than did AF culture; and 3) sterile intra-amniotic inflammation was present in 29% of these patients, and it was as or more common than microbial-associated intra-amniotic inflammation among those presenting after, but not before, 24 weeks of gestation.

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“…82 The presence of intra-amniotic inflammation (both microbial and sterile) is associated with adverse pregnancy outcomes 35,83–91 in patients presenting with preterm labor and intact membranes, 92–108 preterm pre-labor rupture of the membranes (PPROM), 109–114 a sonographic short cervix, 60,62,82,115 and cervical insufficiency. 58,59,64,116,117 Thus, we and others have explored the behavior of cytokines and other inflammatory-related markers in amniotic 82,100,106–108,118–128 or vaginal 129–140 fluid.…”

Section: | Introductionmentioning

confidence: 99%

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Tarca

Fitzgerald

Chaemsaithong

et al. 2017

American J Rep Immunol

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ProblemTo characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD).Method of studyA retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation).Results(i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later.ConclusionWomen with a SCx at 16–22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.

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Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes

Cited by 38 publications

References 27 publications

First trimester interleukin‐6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients

First trimester interleukin‐6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

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