Cervical Human Papillomavirus Infection in Tunisian Women

Hassen, Elham; Chaïeb, A.; Letaief, Mondher; Khaïri, H.; Zakhama, Abdelfattah; Remadi, Sami; Chouchane, Lotfi

doi:10.1007/s15010-003-3112-7

Cited by 36 publications

(50 citation statements)

References 25 publications

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“…Consistent condom use with clients varied, with a range of 16%-77% in Africa [16, 17], 65.7-99.2% in the Americas [9,18], 37% in the Eastern Mediterranean [19], 50% in Europe [20], 69.3-82.9% in Southeast Asia [21, 22] and 85-90.8% in the Western Pacific [15,23]. Other popular mechanisms of contraceptives were the barrier method [9] and microbicides [17].…”

Section: Resultsmentioning

confidence: 99%

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Soohoo¹,

Blas²,

Byraiah³

et al. 2013

TOAIDJ

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Introduction: Approximately 291 million women worldwide are HPV DNA carriers. Studies have indicated that having multiple sexual partners may lead to higher HPV transmission. Thus female sex workers (FSWs) may be at greater risk of infection compared to the general population. Herein we review publications with data on FSW cervical HPV test results. We also examine variations of HPV prevalence and risk behaviors by region. Knowledge of prevalent HPV types in FSWs may lead to improved prevention measures and assist in understanding vaccination in high-risk groups.Methods: We conducted a review of the literature by searching PUBMED using the terms “prostitution” or “female sex workers”, “human papillomavirus” or “HPV”, and “prevalence” or “PCR” to find articles. We excluded studies without HPV testing or HPV type specific results, or unconventional HPV testing.Results: A total of 35 peer-reviewed publications were included in our review. High risk HPV types 16 and 18 ranged from 1.1-38.9‰ in prevalence. In addition to high-risk HPV types, newer studies reported non-carcinogenic HPV types also of high prevalence. The most prevalent HPV types reported among FSWs included HPV 6 (11.5%), 16 (38.9%), 18 (23.1%), 31 (28.4%), 52 (32.7%), and 58 (26.0%).Conclusions: Female sex workers have an overall high prevalence of HPV infection of high-risk types as evident through various testing methods. FSWs are thought to be at increased risk of cervical cancer because of high HPV exposure. This highlights the need for HPV and cervical prevention campaigns tailored to FSWs.

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Section: Resultsmentioning

confidence: 99%

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Soohoo¹,

Blas²,

Byraiah³

et al. 2013

TOAIDJ

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“…The first molecular studies published results on the HPV infection among women with normal cervical cytology having different lifestyle practices [20, 21]. Recently, HPV type and variants distribution have been assessed in cervical tumor tissues from Tunisian patients [24].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Previously, Hassen et al, published HPV prevalence in women with normal cervical cytology from the central region of Tunisia (Sousse and Monastir) [20]. They observed a higher HPV prevalence in prostitutes (39%) compared to married women (14%) [20]. Herein, the slight increase in HPV prevalence among married women could be due to the use of the q-PCR method, which is more sensitive than the conventional PCR used previously by Hassen et al, rather than the change in the lifestyle and sexual habits in both Tunisian men and women.…”

Section: Discussionmentioning

confidence: 99%

“…So far, few molecular epidemiological studies on HPV infections have been conducted in North-African countries, which is a region located at a crossroad of Southern Europe, Sub-Saharan Africa and the broader Middle East [20–22]. This location allows meeting, crossing and interaction of the different Mediterranean civilizations that had lived in North Africa along several centuries (Berber, Arabo-Islamic, Ottoman and European).…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Ghedira

Mahfoudh

Hadhri³

et al. 2016

Infect Agents Cancer

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BackgroundLittle is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HPV type and HPV-16 variants among cervical-screened unvaccinated Tunisian women.MethodsCross-sectional study was performed on 494 Tunisian women visiting Women’s Healthcare Centers. HPV-DNA detection was carried out on cervical samples using real-time polymerase chain reaction. HPV genotyping and HPV-16 variants were characterized by direct sequencing of L1 viral capsid gene.ResultsThe overall HPV prevalence was 34% (95% CI: 30–38%) with significantly higher prevalence among women with squamous intraepithelial lesions (SIL) than those with no intraepithelial lesions (NIL) 84% (95% CI: 76–92%) and 24.5% (95% CI: 20–29%) respectively. The distribution of HPV prevalence according to women’s age shows a U-shaped curve and the highest HPV prevalence rates were observed among the youngest (≤25 years; 51.2%, 95% CI: 37–67%) and the oldest women (>55 years; 41.7%, 95% The HPV-16 prevalence was 32.8% (95% CI: 22–45%) among women with SIL and 9.2% (95% CI: 6–12%) among women with NIL. Whereas, the HPV-18 prevalence was 1.3% (95% CI: 0–5%) among women with SIL and 0.3% (95% CI: 0–1%) among women with NIL. Among HPV-16 positive women, European lineage (E) was identified as the predominant HPV-16 variant (85.7%, 95% CI: 76–95%). The frequency of E variant was lower among SIL than among NIL women (81%, 95% CI: 64–99%, and 88%, 95% CI: 77–100%, respectively). Conversely, the African-2 variant frequency was higher among SIL than among NIL women (18%, 95% CI: 1–36% and 6%, 95% CI: 2–14%, respectively). In multivariate analysis, young age was the only risk factor that is independently associated with HPV infection. Moreover, HPV infection and menopause were both found to be independently associated with SIL and HSIL.ConclusionHPV DNA testing should be proposed to young and menopausal Tunisian women. Considering HPV prevalence, only 13% of the Tunisian women could be protected by the bivalent HPV vaccine. These results may be helpful for designing an adapted HPV testing and vaccination program in Tunisia.

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Cervical carcinoma in Algiers, Algeria: Human papillomavirus and lifestyle risk factors

Hammouda¹,

Muñóz

Herrero

et al. 2004

Intl Journal of Cancer

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We conducted a hospital-based case-control study in Algiers, Algeria. A total of 198 cervical carcinoma (CC) cases (including 15 adeno-and adenosquamous carcinomas) and 202 age-matched control women were included. Human papillomavirus (HPV) DNA in cervical cells was evaluated using a PCR assay. Odds ratios and corresponding confidence intervals were computed by means of unconditional multiple logistic regression models. HPV infection was detected in 97.7% of CC cases and 12.4% of control women (OR ‫؍‬ 635). Nineteen different HPV types were found. HPV 16 was the most common type in both CC cases and control women,

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Cervical Human Papillomavirus Infection in Tunisian Women

Cited by 36 publications

References 25 publications

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Cervical carcinoma in Algiers, Algeria: Human papillomavirus and lifestyle risk factors

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