Cervical intraepithelial neoplasia in adolescents: study of cytological findings between 1987 and 1995 in São Paulo State-Brazil

Utagawa, Maria Lúcia; Pereira, Sônia Maria Miranda; Cavaliere, Maria José; Maeda, Marina Yoshiê Sakamoto; Shih, Lai Wun Song; Shirata, Neuza Kasumi

doi:10.1007/s004040050228

Cited by 14 publications

(11 citation statements)

References 7 publications

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“…23 Another study followed adolescents in Sao Paulo, Brazil over 9 years, and found a 76.5% to 100% prevalence of low-grade lesions in cases with abnormal Pap smears. 24 A study of AYAs (15 to 20 y of age) in the North of Brazil showed that 6.4% had abnormal PAP smears, of which 94.2% corresponded to epithelial lesions and 5.8% to adenocarcinoma. 25 In Canada, a study investigated the incidence of cervical neoplasia among 15-to 29-year-old women between 1970 and 2007, and reported a declining trend during this period, mainly with regards to squamous cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence Among Adolescents and Young Adults (15 to 29 Years) in Brazil

Balmant¹,

Reis²,

Oliveira³

et al. 2016

Journal of Pediatric Hematology/Oncology

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The spectrum of cancers commonly found in adolescents and young adults (AYAs) differs from those in children and adults; therefore, the childhood classification is not appropriate for this population. Here we used a newly proposed classification system to reclassify cases of AYAs from Brazilian population-based cancer registries (PBCRs) in 5 geographic regions of Brazil. We aimed to describe the cancer incidence rates within this age group according to PBCR. Using the world population, incidence rates per million were analyzed in each diagnostic subgroup according to sex and age at diagnosis (15 to 19 y, 20 to 24 y, and 25 to 29 y). The median incidence rate was 232.31 per million for females and 218.07 per million for males. Incidence increased with age, with the highest rate observed for 25- to 29-year-olds in both sexes. Carcinomas, lymphomas, and skin tumors were most frequent among AYAs. High incidence rates of cervix-uterus carcinoma were observed in most PBCRs. AYAs present epidemiological characteristics that differ from those of children, reinforcing the need for a new classification. This study describes, for the first time, the cancer incidence rate in AYAs in Brazil, and we believe that our findings represent the Brazilian profile.

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Section: Discussionmentioning

confidence: 99%

Cancer Incidence Among Adolescents and Young Adults (15 to 29 Years) in Brazil

Balmant¹,

Reis²,

Oliveira³

et al. 2016

Journal of Pediatric Hematology/Oncology

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“…Mount & Papillo 17 also reported a high prevalence of SIL (3.7%) in 10,296 colpocytologies in adolescents as compared to the 20-29-year group (SIL = 3.5%) and women over 30 years (SIL = 1.27%). Utagawa et al 18 , in a study from 1987 to 1995, found HSIL in 7.7% of their sample, noting that the prevalence of abnormal cytopathologies in adolescents almost quadrupled, while Roye 19 reported an increase from 2% in 1973 to 6% in 1978.…”

Section: Discussionmentioning

confidence: 99%

Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors

et al. 2006

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The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA) and high-grade squamous intraepithelial lesions (HSIL) IntroductionWorldwide, cervical cancer is one of the most frequent malignant neoplasms in women, with 400,000 cases diagnosed per year, second only to breast cancer 1,2,3 . In Brazil, 20,690 new cases are expected in 2005, with a risk of 22 cases per 100,000 women. It is the most common neoplasm in the North of Brazil (23/100,000). In the South (31/100,000), Central West (23/100,000), Southeast (22/100,000), and Northeast (18/100,000) it is the second most frequent tumor, and every day ten women die from this disease 4 .In 1996, the Brazilian Ministry of Health, with consultancy from the Ontario Cancer Treatment and Research Foundation (Canada), drafted the National Cervical Cancer and Breast Cancer Program (known as Programa Viva Mulher), which was implemented in 1997 5,6 . Since the highest incidence of cervical cancer is from 35 to 49 years of age, the Program extended the safety range by ten years (above and below) so as to conduct activities targeting women from 25 to 59 years 6 .However, the first infection with human papillomavirus (HPV) generally occurs at the beginning of sexual activity 7,8 , and since sexual debut has occurred at increasingly early ages, this creates a window of approximately ten years between contact with the virus and the first Pap smear.Many cases of HPV infection do not cause symptoms and resolve spontaneously 9 . However, persistent cases may develop into precursor ARTIGO ARTICLE

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“…A infecção por Candida sp tem sido encontrada em aproximadamente 25% das pacientes com infecção por HPV 15 . Trabalhos demonstraram índices mais altos de infecções e lesões neoplásicas não-invasivas nos exames de Papanicolaou de adolescentes em comparação com mulheres adultas 16,17 . Conforme exposto acima, na adolescência parece haver fenômenos que facilitam a infecção pelo HPV e outros microrganismos.…”

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Infecção pelo Papilomavírus Humano em Adolescentes: Relação com o Método Anticoncepcional, Gravidez, Fumo e Achados Citológicos

Murta¹,

Souza²,

Adad³

et al. 2001

Rev. Bras. Ginecol. Obstet.

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Independentemente da faixa etária, fatores relacionados à maior freqüência de infecção pelo HPV, como a gravidez, hábito de fumar, método anticoncepcional e infecções genitais, têm sido estudados. Alguns autores demonstraram maior incidência de infecção por HPV em gestantes, sugerindo ser a gestação um fator de risco independente para infecção por HPV [3][4][5] . No entanto, outros autores descrevem incidência igual ou menor em mulheres gestantes em relação às não-gestantes [6][7][8] . Em relação aos métodos contraceptivos, o uso de anticoncepcional oral (ACO) parece ser um fator de risco isolado para aumentar a incidência de infecção por HPV. Este aumento é explicado por alterações hormonais que levariam a imunomodulação 9 com maior susceptibilidade à

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Cervical intraepithelial neoplasia in adolescents: study of cytological findings between 1987 and 1995 in São Paulo State-Brazil

Cited by 14 publications

References 7 publications

Cancer Incidence Among Adolescents and Young Adults (15 to 29 Years) in Brazil

Cancer Incidence Among Adolescents and Young Adults (15 to 29 Years) in Brazil

Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors

Infecção pelo Papilomavírus Humano em Adolescentes: Relação com o Método Anticoncepcional, Gravidez, Fumo e Achados Citológicos

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