Cervical lymphadenopathy: scrofula revisited

Khan, Rizwan; Harris, SA; Verma, Amita; Syed, Akbar

doi:10.1017/s0022215108003745

Cited by 41 publications

(36 citation statements)

References 11 publications

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“…Other previous studies have defined gold standards using composites of diagnostic modalities (e.g. presence of granuloma or presence of AFBs or culture positivity), and sometimes a combination of microbiological and clinical methods 7–10,15,16,18,19,23,24 . However, these all suffer from uncertainty regarding the true specificity of each component diagnostic modality (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…presence of granuloma or presence of AFBs or culture positivity), and sometimes a combination of microbiological and clinical methods. [7][8][9][10]15,16,18,19,23,24 However, these all suffer from uncertainty regarding the true specificity of each component diagnostic modality (e.g. presence of granuloma), and therefore of the true specificity of the gold standard reference itself.…”

Section: Diagnosis Of Tuberculous Lymphadenitismentioning

confidence: 99%

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Diagnosis of tuberculous lymphadenitis using fine needle aspiration biopsy

Knox¹,

Lane²,

Wong

et al. 2012

Internal Medicine Journal

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Background: Tuberculous lymphadenitis is the commonest form of extrapulmonary tuberculosis. However, the optimal approach to diagnosis, employing biopsy by either fine needle aspiration (FNA) or surgical excision, remains uncertain. Aims: To evaluate the diagnostic value of biopsy using each of the component diagnostic modalities of FNA (microscopy, cytology and culture), and compare these with excision biopsy in the diagnosis of tuberculous lymphadenitis in a predominantly migrant population in Melbourne. Methods: A retrospective examination of tuberculous lymphadenitis cases presenting to Western Health over 12 years was conducted. Using a reference method of positive culture of Mycobacterium tuberculosis, the diagnostic sensitivities of each modality employed in FNA were determined. Results: Forty‐two subjects having FNA and 30 having excision biopsy as the initial investigation were compared. Among specimens obtained by FNA, sensitivity of microscopy was 18% (95% confidence interval (CI): 5–40%) and sensitivity of cytology was 38% (95% CI: 20–59%). For specimens obtained by excision biopsies, sensitivities for microscopy and histology were 17% (95% CI: 2–32%) and 96% (95% CI: 88–100%) respectively. Sensitivity of culture performed on FNA specimens was 86% (95% CI: 65–97%). Conclusions: Given the relatively high sensitivity of mycobacterial cultures from FNA, this study supports its routine use as the initial investigation in most patients with suspected tuberculous lymphadenitis. Microscopy and cytology add relatively little to the clinical utility of FNA.

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Section: Discussionmentioning

confidence: 99%

Section: Diagnosis Of Tuberculous Lymphadenitismentioning

confidence: 99%

Diagnosis of tuberculous lymphadenitis using fine needle aspiration biopsy

Knox¹,

Lane²,

Wong

et al. 2012

Internal Medicine Journal

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show abstract

“…10 The commonest form of extrapulmonary tuberculosis is scrofula, also known as cervical lymphadenitis. 9 A number of tests are available to attempt to make the diagnosis of abdominal tuberculosis, including tuberculin skin testing, ascitic fluid analysis, ascitic culture, and ascitic adenosine deaminase levels. A PPD is positive in approximately 70% of patients, but a negative test cannot exclude the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

An Indonesian Male with Abdominal Pain and Weight Loss: Abdominal Tuberculosis Presenting with Cervical Lymph Node Enlargement

Kaye¹,

Littlejohn

2012

TMF

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“…Second in involvement were jugulodigastric nodes, which accounted to 14.86%. Maharajan et al, [13] and Khan et al [14] found the posterior group involved in 42 % and 43.8 % respectively. Our findings were comparable to these studies.…”

Section: Most Common Nodes Affected In Tuberculosismentioning

confidence: 94%