Cervical Pemphigus Vulgaris Presenting as Postmenopausal Bleeding

Smith, Stephen M.; Moscarelli, Richard D.; Panse, Gauri; Parkash, Vinita

doi:10.1097/pgp.0000000000000724

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Nail involvement usually occurs when the disease is severe and in most cases responds partially or completely to systemic therapy [1,19]. In the literature, two patients with cervical pemphigus vulgaris with symptoms as postmenopausal bleeding have been reported [22].…”

Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus Vulgaris

Kucuk¹,

Taşlıdere²

2023

Wound Healing - Recent Advances and Future Opportunities

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Pemphigus vulgaris is a life-threatening bullous disease characterized by acantholysis resulting in the formation of intraepithelial blebs in the mucous membranes and skin. It is a chronic autoimmune bullous dermatosis caused by the production of autoantibodies against desmoglein 1 and 3. It often begins with blisters and erosions on the oral mucosa, followed by lesions on other mucous membranes and drooping blisters that may spread to the skin. If there is clinical suspicion, the diagnosis can be confirmed by cytological examination, histopathological examination, direct and indirect immunofluorescence tests. Before the introduction of corticosteroids, PV was fatal due to dehydration or secondary systemic infections. The mainstay of treatment is still systemic steroids. Immunosuppressants such as azathioprine, mycophenolate mofetil and methotrexate, high-dose intravenous immunoglobulins, CD20 monoclonal antibody Rituximab treatments are used as an adjuvant with steroids in suitable patients and successful results are obtained.

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Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus Vulgaris

Kucuk¹,

Taşlıdere²

2023

Wound Healing - Recent Advances and Future Opportunities

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“…2021 [4] Case Report Two cases of pemphigus vulgaris in women presented with associated postmenopausal bleeding. The site of bleeding was established to be related to cervical involvement in one patient and assumed to be of cervical origin in the latter.…”

Section: Design Findings Treatmentmentioning

confidence: 99%

“…The classic presentation of PV involves the oral cavity, with the appearance of painful blisters and erosions on the mucosa, followed by the development of skin lesions. However, PV can also have atypical presentations that may lead to a delayed or missed diagnosis [4][5][6][7][8][9][10][11]. These can be structural (pemphigus vegetans) or anatomic (scalp and nail pemphigus).…”

Section: Gupta Et Al 2003 [7]mentioning

confidence: 99%

“…Atypical presentations of PV are rare but can occur. These include pemphigus vegetans, pemphigus herpetiformis, and paraneoplastic pemphigus [4]. Pemphigus vegetans presents as hypertrophic vegetating lesions in intertriginous areas, while pemphigus herpetiformis is characterized by a vesicular eruption that resembles dermatitis herpetiformis.…”

Section: Introductionmentioning

confidence: 99%

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Scalp, Oral, and Nail Pemphigus Vulgaris: Clinical Characteristics and a Review of the Literature

Eachus¹,

DeLamielleure²,

Mitha³

et al. 2023

Cureus

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Pemphigus vulgaris (PV) is a rare disease that affects the skin and mucous membranes, causing blistering and erosions. Identifying and effectively managing atypical presentations of pemphigus vulgaris can be challenging due to its rarity. We describe a 32-year-old male patient with a medical history including prediabetes, moderate asthma, hyperlipidemia, coccidioidomycosis, and respiratory infections. He was evaluated via telehealth in the allergy and immunology clinic for uncontrolled asthma. Initially, he complained of a whitish film in the mouth while on treatment with fluticasone and salmeterol. He also noted new vesicular lesions on his scalp and body. When evaluated later in the clinic, he was found to have oral and periungual erosions as well as paronychia. After promptly referring to dermatology, histopathological examination and direct immunofluorescence testing were performed on the patient's lesions, revealing changes consistent with PV. Treatment with prednisone and rituximab resulted in the complete resolution of the patient's bullae and nail deformities over several months. This case highlights the importance of a thorough evaluation of complex medical histories and diagnostic testing in managing asthma and allergy symptoms. It also emphasizes the need for a multidisciplinary approach involving specialists such as immunologists, dermatologists, and infectious disease experts in the diagnosis and management of complex cases.

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Immunobullous Disease

Nylander¹

2022

Ridley's the Vulva

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Cervical Pemphigus Vulgaris Presenting as Postmenopausal Bleeding

Cited by 3 publications

References 20 publications

Pemphigus Vulgaris

Pemphigus Vulgaris

Scalp, Oral, and Nail Pemphigus Vulgaris: Clinical Characteristics and a Review of the Literature

Immunobullous Disease

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