Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining

Balmagambetova, Saule; Gabutti, Giovanni; Koyshybaev, Arip; Martellucci, Cecilia Acuti; Urazayev, Olzhas; Kanshaiym, Sakiyeva; Bekova, Karlygash

doi:10.1177/0969141319885409

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…In the second study conducted in Western Kazakhstan, the prevalence of HPV was found to be 25%, and the most common HPV genotypes were HPV-16 (26.40%), HPV- 31 (10.10%), HPV-51 (9.40%), HPV-52 (9%), and HPV-6 (7.90%). 22 The major subtypes resulting in high-risk HPV infection types in Jinhu area were 52, 58, 16, 53, 56, and 33, which was not consistent with previous reports on different subtype infection rates across most regions of China. HPV16, together with HPV 18, is known to be responsible for approximately 70% of cervical cancer cases worldwide.…”

Section: Discussioncontrasting

confidence: 83%

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Wang¹,

Chen²,

Jiang³

2021

CMAR

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Objective Human papillomavirus (HPV) infection is the risk factor for cervical cancer. Consequently, HPV DNA testing is an essential method for cervical cancer screening. Yet, data on the prevalence and genotype distribution of HPV and cervical cytological among women in northern Jiangsu Province of China are very limited. Materials and Methods A total of 36,500 women were enrolled at the Department of Pathology of Jinhu County People’s Hospital between January 1, 2016 and December 31, 2019. HPV genotypes was performed using YanengBio ® Human Papillomavirus Genotyping Kit. Thin liquid cytology tests (TCT) were conducted, based on cytology conditions set by Bethesda in 2001. Results The overall prevalence of HPV infection was 28.95%; it was age-dependent; the number of infections was highest in the 40–49 age group. Six thousand three hundred eighty-two women (16.87%) were found to have a pure high-risk HPV infection, while 918 women (2.43%) were found to have a pure low-risk HPV infection. The 6 most predominant genotypes were HPV 52, 58, 16, 53, 56, and 33. Moreover, 8923 women (45.09%) were affected by ASCUS, 4531 (22.90%) by LSIL, 3726 (18.83%) by ASC-H, and 2610 (13.19%) by HSIL. Conclusion This study revealed a high burden of HPV infection among women in northern Jiangsu Province of China and identified the distribution of the prevalent top 6 HPV genotypes in this area, which can be used as a useful reference for future work.

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Section: Discussioncontrasting

confidence: 83%

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Wang¹,

Chen²,

Jiang³

2021

CMAR

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“…In our pilot study conducted in 2017 the overall HR-HPV prevalence was 43.6% and HPV-33, HPV-51 and HPV-52 were the most prevalent [ 6 ]. Another study published in 2019 found 25% HR-HPV positive patients, and among the most prevalent HR-HPV genotypes were HPV-33 (4.9%), HPV-51 (4.9%) and HPV-52 (4.9%) [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

The Distribution and Prevalence of High-Risk HPV Genotypes Other than HPV-16 and HPV-18 among Women Attending Gynecologists’ Offices in Kazakhstan

Aimagambetova

Babi

Akhanova³

et al. 2021

Biology

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Cervical cancer represents a great burden to public health of women. This study aimed to obtain a nationwide genotyping survey and analysis of high risk-HPV including those that are caused by HPV types other than HPV-16 and HPV-18, among women in Kazakhstan. This study was conducted based on the collection of survey and cervical swabs of 1645 women across the country. The samples were genotyped for high-risk HPV types based on real-time PCR methods. Collected data was analyzed with the focus on high-risk HPV types other than HPV-16 and -18. Infection was present in 22% of women who participated in the study. The most prevalent types were HPV-31 among single infections and HPV-68 among multiple infections. Conclusively, despite the lack of attention high-risk HPV types beyond HPV-16 and -18 get in attempts of cervical cancer prevention in Kazakhstan, their prevalence is high and plays a large role in cervical cancer epidemiological situation.

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“… 2 Kazakhstan exhibits a high CC incidence rate in women of all ages, and it has risen significantly to 18.2 per 100,000 women. 3 , 4 The age-standardized incidence and mortality were 15.7 and 7.5 per 100,000 women, respectively (estimates for 2018). 3 About 1729 new CC cases are diagnosed annually in Kazakhstan, and CC ranks as the second leading cause of cancer and cancer-related death in women.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 7 The Kazakhstani national screening programme has undergone significant positive changes over the past 12 years since it was implemented in 2008. 4 Initially, based on conventional Papanicolaou testing (Pap smear), screenings were performed every 5 years in the target group of women aged 30–60 years. 4 From December 2017, the screening interval was reduced to 4 years, and the age of the target group was extended to 70 years.…”

Section: Introductionmentioning

confidence: 99%

“… 4 Initially, based on conventional Papanicolaou testing (Pap smear), screenings were performed every 5 years in the target group of women aged 30–60 years. 4 From December 2017, the screening interval was reduced to 4 years, and the age of the target group was extended to 70 years. 4 , 5 However, despite these efforts, the CCS coverage decreased from 72.9% in 2008 to 45.9% in 2016, 9 and the high CC incidence and mortality rates in Kazakhstan reveal that the screening programme does not work effectively.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with cervical cancer screening behaviour of women attending gynaecological clinics in Kazakhstan: A cross-sectional study

Issa

Babi

Azizan

et al. 2021

Womens Health (Lond Engl)

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Objective: Although cervical cancer could be prevented through medical screening, it remains one of the top causes of cancer-related morbidity and mortality all over the world. A number of factors may contribute to cervical cancer screening behaviour of women. The aim of this study was to investigate factors related to cervical cancer screening behaviour of women in Kazakhstan. Methods: This was a cross-sectional survey-based study with a total of 1189 participants. Women attending gynaecological clinics aged between 18 and 70 years were administered paper-based questionnaires about their awareness of cervical cancer, the associated risk factors, and cervical cancer screening. Student t test or Wilcoxon rank-sum test and chi-square test or Fisher’s exact test, where appropriate, were used to determine associations with categorical independent variables. Results: The mean age of participants was 36.5 ± 10.1 years. Less than half (45.7%) of the participants had been screened for cervical cancer. The key factors related to the cervical cancer screening behaviour of women in this study included age, having a larger number of children, regular menstrual function, awareness of Pap smear test, and free screening programme for cervical cancer, and the causal association of human papillomavirus with cervical cancer. Conclusion: This study revealed several significant factors predicting screening behaviour in Kazakhstani women. To improve the rate of screening, there is a need to increase public knowledge and awareness of cervical cancer and opportunities for the free screening programme in the female population of Kazakhstan.

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Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining

Cited by 11 publications

References 22 publications

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

The Distribution and Prevalence of High-Risk HPV Genotypes Other than HPV-16 and HPV-18 among Women Attending Gynecologists’ Offices in Kazakhstan

Factors associated with cervical cancer screening behaviour of women attending gynaecological clinics in Kazakhstan: A cross-sectional study

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