Cervical spinal cord stimulation for prevention and treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: clinical and radiographic outcomes of a prospective single-center clinical pilot study

Slavin, Konstantin V.; Vannemreddy, Prasad

doi:10.1007/s00701-022-05325-4

Cited by 3 publications

(2 citation statements)

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“…In our study, we have shown for the first time the effectiveness of chronic epidural electrical stimulation of the spinal cord in chronic cerebral ischemia. Given that perfusion changes are observed mainly in the frontoparietal cortex, our results may be potentially useful for developing methods for correcting cognitive impairment in patients with various forms of dementia, as well as for reducing age-related vascular disorders in the elderly (15,27,28). Mechanisms for improving cerebral blood flow during electrical stimulation of the spinal cord have not been sufficiently studied (17,18,21).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, various methods of neuromodulation based on epidural electrical stimulation of the spinal cord have been proposed in clinical practice for the correction of peripheral hemodynamic disorders in patients suffering from refractory angina pectoris or peripheral vasculopathy (6)(7)(8)(9)(10)(11). Also, in many experimental and clinical studies, a positive effect of electrical stimulation of the spinal cord on the hemodynamic and functional parameters of the brain was noted in certain pathological conditions associated with dysfunction of the vascular bed, such as ischemia, subarachnoid hemorrhage, head trauma and brain tumors (10,(12)(13)(14)(15)(16). Most of the conducted clinical and experimental studies devoted to the study of the short-term effect of the upper (at the level of C2-C3 of the cervical spinal cord) electrical stimulation of the spinal cord were performed, as a rule, in acute and severe circulatory disorders, accompanied by critical neurological disorders and the development of a vegetative state, such as stroke, vasospasm, or traumatic brain injury (TBI) (17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

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Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation

Суфианова

Шапкин²,

Mashkin

et al. 2022

Front. Surg.

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ObjectiveIncreasing life expectancy and aging of the population is accompanied by a steady increase in the number of elderly patients with chronic cerebral ischemia and age-related cognitive impairment associated with cerebral hypoperfusion and microangiopathy. The aim of this study was to identify long-term changes in cerebral blood flow (CBF) in patients with chronic cerebral ischemia at the epidural electrical stimulation of the spinal cord (SCS).Materials and methodsChanges in cerebral blood flow were studied according to CT perfusion in 59 patients (aged 55–78 years) with vertebrogenic pain syndromes and chronic cerebral ischemia during epidural electrical stimulation of the spinal cord at the cervical (C3–C5) and lower thoracic (Th9–Th10) levels.ResultsIn all patients, on the 5th day of trial SCS, an increase in cerebral blood flow by from 58.6 ± 1.13 ml/100 ml/min to 64.8 ± 1.21 ml/100 ml/min (p < 0.01) with stimulation at the Th9-Th10 level and from 58.8 ± 1.12 ml/100 ml/min to 68.2 ± 1.42 ml/100 ml/min (p < 0, 01) with stimulation at the C3-C5 level. These changes in brain perfusion were preserved during the follow-up examination 1 year after the implantation of chronic SCS system. The greatest increase in CBF was registered in the frontotemporal regions, subcortical structures and white matter of the brain. Changes in cerebral perfusion did not correlate with the degree of reduction in the severity of the accompanying pain syndrome. The change in CBF in the control group (32 patients) in all periods was not statistically significant.ConclusionOur results show that SCS is accompanied by a persistent improvement in brain perfusion, which may be potentially useful for developing methods for reducing age-related vascular disorders in the elderly.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation

Суфианова

Шапкин²,

Mashkin

et al. 2022

Front. Surg.

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Neuromodulation for Post-SAH Cerebral Vasospasm

Slavin

Vannemreddy

2022

Neuromodulation: Technology at the Neural Interface

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Neurorehabilitation of post-stroke motor dysfunctions using spinal electrostimulation

Stolbkov,

Gerasimenko

2024

Uspehi fiziologičeskih nauk

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Spinal cord injuries and strokes are the main causes of complete or partial loss of movement. Advances in minimizing motor dysfunction using spinal electrical stimulation in spinal cord injuries have contributed to increasing interest in the use of this type of neuromodulation for motor disorders of other pathologies. The review presents the results of recent studies on the use of various types of spinal electrical stimulation to minimize motor dysfunctions associated with cerebral blood flow disorders, and discusses the history of the use of spinal stimulation in this area.

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Cervical spinal cord stimulation for prevention and treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: clinical and radiographic outcomes of a prospective single-center clinical pilot study

Cited by 3 publications

References 46 publications

Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation

Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation

Neuromodulation for Post-SAH Cerebral Vasospasm

Neurorehabilitation of post-stroke motor dysfunctions using spinal electrostimulation

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