Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-α and histamine whereas normal keratinocytes undergo cytolysis

Diaconu, Nicolae-Costin; Rummukainen, Jaana; Mättö, Mikko; Harvima, Rauno J.; Pelkonen, Jukka; Harvima, Ilkka T.

doi:10.1186/1471-2407-8-46

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Interestingly, the authors found that the combination of 10 µM histamine and 1 ng ml -1 TGF-β resulted in an additive effect on MMP-9/TIMP-1 production. This result thus further extends the previous findings about histamine-TNF-α and histamine-IFN-γ combinations in keratinocyte stimulation (Matsubara et al, 2005;Giustizieri et al, 2004;Diaconu et al, 2008). In the ex vivo experiments in skin biopsies, the authors demonstrated further that exogenously added 10 µM histamine induced MMP-9 in skin biopsies after incubation for 16 h, as detected with zymography of the extracted protein.…”

Section: Histamine Induces Mmp-9 In Keratinocytes and Epidermissupporting

confidence: 86%

“…Furthermore, histamine can augment, through the H1 receptor, IFN-γ-induced expression of major histocompatibility complex class I, ICAM-1, GM-CSF, CCL-5/RANTES, CCL-2/MCP-1, CCL-20/MIP-3α, and CXCL-10/IP-10 in human keratinocytes (Giustizieri et al, 2004). On the other hand, histamine has been thought to control the growth of the epidermis, because histamine can inhibit the growth of monolayer keratinocytes and keratinocyte epithelium, and this effect is potentiated even to cytolysis when histamine affects keratinocytes together with TNF-α (Diaconu et al, 2008).…”

Section: Histamine and Epidermismentioning

confidence: 99%

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Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Harvima

2008

Journal of Investigative Dermatology

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Mast cells and their mediator, histamine, are well-recognized effectors in immediate allergy, but their role in tissue remodeling and chronic inflammation has also been the focus of intense research during the past decade. Gschwandtner et al. (2008, this issue) report that histamine can induce MMP-9 expression in keratinocytes, promote collagen type IV degradation in the basement membrane, and stimulate keratinocytes, leading to increased T-cell transmigration through an artificial basement membrane.

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Section: Histamine Induces Mmp-9 In Keratinocytes and Epidermissupporting

confidence: 86%

Section: Histamine and Epidermismentioning

confidence: 99%

Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Harvima

2008

Journal of Investigative Dermatology

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“…Although a moderate TNF level is necessary to maintain cell protected and prevent certain diseases through regulation of the immune response, excessive TNF secretion due to pathological conditions is associated with autoimmune diseases, infectious diseases and malignant tumors (9). In cervical cancer, TNF promotes cell cycle progression by increasing cyclin-dependent kinase activity and HPV16 E6/E7 RNA expression in HPV-immortalized keratinocytes (9, 10). It also enhances the transcription and stability of epidermal growth factor receptor (EGFR), resulting in cell proliferation and tumorigenesis (9, 11).…”

Section: Introductionmentioning

confidence: 99%

Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

Matos

Cândido

Vidigal

et al. 2016

Tumori

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Introduction The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inﬂammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions. Methods A total of 64 embedded tissues were obtained from gynecological procedures, including 35 specimens with cervical intraepithelial neoplasia (CIN) and 10 specimens with cervical squamous cell carcinoma (CSCC) as well as 19 normal cervical samples. The expression of TLR2, TLR3, TLR4, TNF-α and TNF-β was measured by immunohistochemistry and graded into low and high levels of expression. Results There was an association between the expression levels of TLR2 and those of TNF-α and TNF-β (p = 0.01 and p = 0.021, respectively) in the cervical cancer and CIN groups. TLR4 expression was associated with TNF-α and TNF-β expression (p = 0.016 and p = 0.025, respectively) in these 2 groups. By contrast, TLR3 was not statistically associated with TNF-α or TNF-β in any of the groups. Conclusions There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer. These markers are also expressed at higher levels in cervical cancer and premalignant lesions compared to normal controls.

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Is there a role for mast cells in psoriasis?

et al. 2008

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Mast cells have traditionally been considered as eVector cells in allergy but during the last decade it has been realized that mast cells are essentially involved in the mechanisms of innate and acquired immunity. Upon activation by anaphylactic, piecemeal degranulation or degranulation-independent mechanisms mast cells can secrete rapidly or slowly a number of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express cell surface co-stimulatory receptors and ligands, and they can express MHC class II molecules and thereby present antigens. These soluble factors and cell surface molecules can interact with other cells, such as endothelial cells, keratinocytes, sensory nerves, neutrophils, T cell subsets and antigen presenting cells which are essential eVectors in the development of skin inXammation. Besides promoting inXammation, mast cells may attempt in some circumstances to suppress the inXammation and epidermal growth but the regulation between suppressive and proinXammatory mechanisms is unclear. Psoriasis is characterized by epidermal hyperplasia and chronic inXammation where tryptase-and chymase-positive MC TC mast cells are activated early in the developing lesion and later the cells increase in number in the upper dermis with concomitant expression of cytokines and TNF superfamily ligands as well as increased contacts with neuropeptide-containing sensory nerves. Due to the intimate involvement of mast cells in immunity and chronic inXammation the role of mast cells in psoriasis is discussed in this review.

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Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-α and histamine whereas normal keratinocytes undergo cytolysis

Cited by 4 publications

References 40 publications

Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

Is there a role for mast cells in psoriasis?

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