2007
DOI: 10.1097/brs.0b013e318053ec50
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Cervical Transforaminal Epidural Steroid Injections

Abstract: This study demonstrates a significant risk of serious neurologic injury after cervical TF-ESIs. A growing body of evidence supports an embolic mechanism, whereby inadvertent intra-arterial injection of particulate corticosteroid causes a distal infarct. Embolism to the distal basilar artery region can cause midbrain, pons, cerebellum, thalamus, temporal and occipital lobe infarctions. Other potential mechanisms of infarction include vertebral artery perforation causing dissection/thrombosis and needle-induced … Show more

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Cited by 272 publications
(185 citation statements)
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“…Some authors advocate injecting anesthetic first, followed by steroid after a short delay to assess neurologic deficit. 29,30,37,38 Our data with SCNRB and Ͼ15,000 transforaminal lumbar nerve injections support the safety of admixing local anesthetic and particulate steroid. This technique decreases the total procedure time, reducing the risk of inadvertent needle movement.…”
Section: Discussionmentioning
confidence: 66%
See 1 more Smart Citation
“…Some authors advocate injecting anesthetic first, followed by steroid after a short delay to assess neurologic deficit. 29,30,37,38 Our data with SCNRB and Ͼ15,000 transforaminal lumbar nerve injections support the safety of admixing local anesthetic and particulate steroid. This technique decreases the total procedure time, reducing the risk of inadvertent needle movement.…”
Section: Discussionmentioning
confidence: 66%
“…1,17,23,24 Although uncommon, complications of SCNRB or transforaminal cervical epidural injections can be devastating. [25][26][27][28][29][30][31][32][33][34][35] Reported major complications include spinal cord and/or brain infarction and death. Direct vascular penetration with intra-arterial injection of anesthetic and particulate steroid, vascular injury with dissection and thrombosis, or direct nerve root or spinal cord injury from the needle or injectant are postulated mechanisms of injury.…”
Section: Discussionmentioning
confidence: 99%
“…4 Eight major complications have been published, but in all more than 30 cases are known. 5 However, many of them have not been published because they are still sub judice. Among the published cases, there is also 1 case in which CSNRB was performed under CT guidance.…”
Section: Discussionmentioning
confidence: 99%
“…7 In 2007, complications were analyzed after an anonymous survey, and proposals were made to reduce the probability of their occurrence: the use of real-time fluoroscopy to detect vascular uptake, nonparticulate corticosteroids such as dexamethasone, and microbore extension tubing ("pigtail") to minimize needle manipulation while changing syringes. 5 CT guidance for dorsal access offers the possibility of still performing a selective block, as the contrast distribution pattern demonstrates. For the therapeutic efficiency of corticoids, it may not be important if the target point is located slightly more distal because of diffusional spread and strong axonal transport of corticoids.…”
Section: Discussionmentioning
confidence: 99%
“…With respect to possible complications, the use of crystalloid and non-crystalloid corticosteroids has been controversial even though there is apparently no major difference in medical effectiveness [45]. It was assumed that complications are based on an embolic mechanism in the case of accidental injection, e. g. into a radicular artery, and corticosteroids with a clumping tendency could have a less favorable risk profile in this context [46]. Tiso et al [47] therefore recommended using non-crystalloid corticosteroids for pain therapy in the cervical spine.…”
Section: Discussionmentioning
confidence: 99%