Cetirizine solubility in supercritical CO2 at different pressures and temperatures

Hezave, Ali Zeinolabedini; Mowla, Amir; Esmaeilzadeh, Feridun

doi:10.1016/j.supflu.2011.05.017

Cited by 46 publications

(23 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Supercritical fluid technologies are being continuously developed in the pharmaceutical industry to obtain ultrapure products and also are popularly favored in drug manufacturing processes because of their abilities to reduce the particle size distribution and control the morphology without contaminating the active ingredient. 15 Generally, experimental techniques are either dynamic or static methods. In previous works, most of the measurements of the solubility of solids in SCCO 2 16−19 and subcritical or supercritical R134a extraction 7,11 have employed dynamic and static methods, respectively.…”

Section: ■ Introductionmentioning

confidence: 99%

Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

et al. 2014

View full text Add to dashboard Cite

The equilibrium solubilities of 4-aminosalicylic acid (PAS) in supercritical carbon dioxide (SCCO 2 ) and subcritical 1,1,1,2-tetrafluoroethane (R134a) are crucial to the process of supercritical and subcritical extraction. After reliability tests of the experimental apparatus were carried out and confirmed, measurements of the solubilities of PAS in SCCO 2 and subcritical R134a were implemented from (11.0 to 21.0) MPa at temperatures of (308 to 328) K by the dynamic method in SCCO 2 and from (5.0 to 15.0) MPa at temperatures of (308 to 328) K by the static method in subcritical R134a, respectively. It was found that the solubility of PAS is much higher in subcritical R134a than in SCCO 2 under the same operational conditions (temperature and pressure). The solubility enhancement factor (δ) was calculated and analyzed. Four density-based models (Chrastil, K-J, M-S-T, and S-S) were used to correlate the PAS solubility data in SCCO 2 and subcritical R134a. The calculated results showed that the reasonable agreement was obtained with the experimental solubility data.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This apparatus is equipped with a sapphire window giving the operator the capability of monitoring inside of the equilibrium cell for possible phase transitions. Upon the capability of this apparatus, the solubility of fluvoxamine maleate is measured using a static method coupled with a gravimetric method [29][30][31][32][33][34][35][36] (see Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…In brief, MST has presented an empirical model based on the theory of infinitely dilute solutions [33]. An equation that follows a simple relationship for the solubility of solids in SCFs was deduced:…”

Section: Semi-empirical Correlation Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Khayyat

Kashkouli

Esmaeilzadeh

2015

Fluid Phase Equilibria

Self Cite

View full text Add to dashboard Cite

“…In this investigation, a home-made apparatus rated for pressures of 60 MPa at 673 K equipped with a sapphire window was used to measure the solubility of model drug using a static method coupled with a gravimetric method [23,24,[33][34][35][36]. The used apparatus in this study was the modified form of its last version used in the previous works [33].…”

Section: Laboratory Apparatusmentioning

confidence: 99%

Experimental solubility measurement of cephalexin in supercritical carbon dioxide

Shojaee¹,

Rajaei²,

Hezave³

et al. 2014

CI&CEQ

Self Cite

View full text Add to dashboard Cite

Article Highlights• Solubility of cephalexin in supercritical carbon dioxide was measured in wide range of temperature and pressure • Solubility of cephalexin was in range of 1.13×10 -5 to 4.89×10 -3 based on mole fraction• Obtained solubilities were correlated using four different semi-empirical correlations AbstractIn recent years, the use of supercritical carbon dioxide for different chemical processes, in particular particle micronization, has surprisingly increased.Knowing the substance solubility in supercritical solvent is a critical parameter during the particle size reduction processes. In this direction, solubility of cephalexin was measured in the supercritical carbon dioxide by changing the temperature and pressure between 308.15 and 338.15 K and from 16 to 40 MPa, respectively. The measured solubility of cephalexin in supercritical carbon dioxide was in the range of 1.13×10 -5 to 4.89×10 -3 based on the mole fraction at the different operational condition. Besides the experimentally measurement of cephalexin solubility, modeling of the results using four commonly used correlations, namely Mendez-Santiago and Teja (MST), Bartle, Kumar and Johnston and Chrastil models were utilized. The results revealed that the Chrastil model was the most accurate used semi-empirical correlation in the present study with the lowest average absolute relative deviation percent of (AARD) of 9.43%.

show abstract

Cetirizine solubility in supercritical CO2 at different pressures and temperatures

Cited by 46 publications

References 28 publications

Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Experimental solubility measurement of cephalexin in supercritical carbon dioxide

Contact Info

Product

Resources

About