CFD-based compartment model for description of mixing in bioreactors

Euler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking

“…The minimal number of compartments for this bioreactor configuration is greater than the number obtained in a previous study (Delafosse et al, 2014) for a flat-bottom bioreactor stirred by two 4-blade Rushton turbines. This difference could be explained by several reasons.…”

“…In a previous work (Delafosse et al, 2014), it has been shown that concentration evolutions are independent of the number of compartments provided that this number is superior to an optimum value.…”

“…In previous papers (Delafosse et al, 2011b(Delafosse et al, , 2014, the CFD/CM has been developed for a flat-bottom 20 L bioreactor stirred by two 4-blade Rushton turbines. Comparison to PIV and tracer experiments showed that the CFD/CM is able to reproduce with an excellent accuracy the mixing of an inert tracer if compared to 'classical' compartment model or even to CFD.…”

A Framework for the Development of Integrated and Computationally Feasible Models of Large-Scale Mammalian Cell Bioreactors

“…In this methodology the reactor is divided into well-mixed zones that do not contain segregated regions. Then fluxes between the zones are calculated based on the expected flow patterns resulting from CFD simulations or experimental data [18,40,41,44]. A number of states of operation are defined by discretizing the process parameters of impeller rotation speed, gas sparging flow rate, and operating volume.…”

“…Compartmental modeling facilitates time-space decomposition, which significantly reduces computation. Therefore, it has been widely used for modeling the hydrodynamics of stirred tanks [40][41][42][43]. In this methodology the reactor is divided into well-mixed zones that do not contain segregated regions.…”