cFos labeling in rat superior colliculus: Activation by normal retinal pathways and pathways from intracranial retinal transplants

Craner, Sandra L.; Hoffman, Gloria E.; Lund, Jennifer S.; Humphrey, Allen L.; Lund, Raymond D.

doi:10.1016/0014-4886(92)90131-9

Cited by 30 publications

(9 citation statements)

References 37 publications

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“…Consistent with our results, Lam et al (1999) have reported that systemic LY354740 increased glucose utilization in the SuG. Changes in visual stimulation also induce c-Fos in the DLG, OT, and SuG, but not in the EW (Craner et al, 1992;Montero and Jian, 1995;Lu et al, 2001). The c-Fos induction observed in the present study may be due to changes in neuronal activity in the retina or to local mGlu2 and/or mGlu3 receptor activation.…”

Section: Central C-fos After Anxiolytic Ly354740supporting

confidence: 92%

“…Our results suggest a role for the EWurocortin pathway in the anxiolytic effects of LY354740. The role of glutamate neurotransmission in the regulation of neuronal activity in the EW is supported by the observation that ionotropic glutamate receptor antagonists such as ketamine also induced c-Fos in the EW (Craner et al, 1992).…”

Section: Central C-fos After Anxiolytic Ly354740mentioning

confidence: 95%

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Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

Lindén

Greene

Bergeron

et al. 2003

Neuropsychopharmacol

101

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LY354740 is a potent and selective agonist for group II metabotropic glutamate (mGlu) receptors, mGlu2 and mGlu3 receptors, with anxiolytic activity in several animal models of anxiety, including the elevated plus maze (EPM) test. Here, we studied neuronal activation in mouse brain after EPM exposure in saline-and LY354740-treated mice using c-Fos immunoreactivity as a marker. The effect of LY354740 on c-Fos expression was also studied in cage control (no EPM) mice. Pretreatment with LY354740 (20 mg/kg, s.c.) produced robust anxiolytic behavior on the EPM. LY354740 administration decreased EPM-induced increases in c-Fos expression in the CA3 of the hippocampus, while having no significant effects on basal c-Fos expression in the hippocampus. LY354740 administration significantly increased c-Fos expression in specific limbic regions, including the lateral division of the central nucleus of the amygdala (CeL), lateral parabrachial nucleus, locus coeruleus, and Edinger-Westphal nucleus, whether or not animals were exposed to the EPM. Moreover, LY354740 administration per se significantly increased c-Fos expression in regions processing sensory information, including the paraventricular and lateral geniculate nucleus of the thalamus as well as the nucleus of the optic tract and superior colliculus. In particular, the suppression of fear-evoked neuronal activity in the hippocampus and drug-induced increases in neuronal activation in the CeL have been previously linked to the anxiolytic effects of clinically effective drugs such as benzodiazepines, and thus may contribute to anxiolytic actions of LY354740 in animal models and human anxiety patients.

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Section: Central C-fos After Anxiolytic Ly354740supporting

confidence: 92%

Section: Central C-fos After Anxiolytic Ly354740mentioning

confidence: 95%

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

Lindén

Greene

Bergeron

et al. 2003

Neuropsychopharmacol

101

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“…This property is of great importance, because it offers a valuable tool for morphofunctional identification of activated neurons (Kaczmarek, 2002). c-Fos induction by light has been mostly studied in rats, mice, rabbits and hamsters, in the suprachiasmatic nucleus in relation to changes of general illumination and circadian rhythms (Rea, 1989;Aronin et al, 1990;Rusak et al, 1990;Chambille et al, 1993;Earnest and Olschowka, 1993;Vuillez et al, 1994); in response to global flashes of light in the retina and central visual pathways Craner et al, 1992;Koistinaho et al, 1993) and after pattern visual stimulation (Yoshida et al, 1993;Montero and Jian, 1995;Harada et al, 1996;Bussolino et al, 1998;CorreaLacarcel et al, 2000;Lima et al, 2003). Sagar et al (1988), in order to determine whether the c-Fos protein and Fos-related proteins can be induced in response to polysynaptic activation, stimulated electrically the rat hindlimb motor/sensory cortex and examined the Fos expression immunohistochemically.…”

mentioning

confidence: 99%

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda¹,

Kretz²

2009

Journal of Chemical Neuroanatomy

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“…In the visual centers of normal rodents, maintained in the dark, very few cells show FLI expression, but, after novel visual stimulation, the number of FLI cells increases dramatically over a period of 2 hours, and then returns to baseline level (Craner et al, 1992;Montero and Jian, 1995). Continuous stimulation over a prolonged period fails to sustain elevated expression, indicating that, as in other systems, FLI expression occurs in response to a changed condition but not to steady-state activity.…”

mentioning

confidence: 88%

Abnormal c‐fos‐like immunoreactivity in the superior colliculus and other subcortical visual centers of pigmented royal college of surgeons rats

Lü

Coffey

Wang

et al. 2004

J of Comparative Neurology

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Neurons in the central nervous system often show a transient up-regulation of expression of the immediate early gene c-fos when presented with precise novel stimuli. In normal rats, neurons in most subcortical visual centers show low levels of fos-like immunoreactivity (FLI) expression, but there is a substantial and transient increase in FLI expression if the animal is exposed to a flashing light. This is especially evident in the superior colliculus (SC). We have examined here FLI expression in the subcortical visual centers of the Royal College of Surgeons rat, focusing specifically on the SC. In this animal, as a result of a genetic defect, there is early loss of rod photoreceptors over the first few months of life, along with slower disappearance of cones. Although light stimulation showed that FLI expression was very similar to that seen in normal rats, the basal levels of FLI expression under dark-maintained conditions were much higher than normal, even exceeding the levels seen after visual stimulation. In the SC, the elevation of FLI expression was already evident by 6 weeks of age and reached a plateau by 17 weeks. Other subcortical visual centers also showed elevated basal levels of FLI expression, although in general the increases were less dramatic than the increase in the SC. The elevated FLI expression in dark-maintained condition seen in the SC was abolished by contralateral optic nerve section. It was also severely diminished by subretinal cell transplantation at 3 weeks of age with the objective of limiting photoreceptor loss over part of the retina. These results suggest that the elevated basal FLI expression is a retina-driven event. Although it correlates with the loss of rod photoreceptors, it is unlikely to reflect reduced photoreceptor drive but rather some form of bursting activity generated in the inner retina, as a result of circuit reorganization or receptor up-regulation.

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cFos labeling in rat superior colliculus: Activation by normal retinal pathways and pathways from intracranial retinal transplants

Cited by 30 publications

References 37 publications

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Abnormal c‐fos‐like immunoreactivity in the superior colliculus and other subcortical visual centers of pigmented royal college of surgeons rats

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