Chaetopyranin, a Benzaldehyde Derivative, and Other Related Metabolites from <i>Chaetomium globosum</i>, an Endophytic Fungus Derived from the Marine Red Alga <i>Polysiphonia urceolata</i>

Wang, Song; Li, Xiaoming; Teuscher, Franka; Li, Dongli; Diesel, Arnulf; Ebel, Rainer; Proksch, Peter; Wang, Bin‐Gui

doi:10.1021/np060248n

Cited by 263 publications

(220 citation statements)

References 22 publications

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“…Endophytes were isolated from healthy C. inerme using the method described by Wang et al (2006), with minor modifications. For endophyte isolation, 10 different healthy segments of the leaves, stems, and roots from C. inerme were selected at random and washed in running tap water.…”

Section: Isolation and Culture Of The Endophytic Fungimentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Fungal endophytes live in the inner tissues of Clerodendrum inerme and may be significant resources for new chemicals in drug discovery. A total of 242 endophytic fungi were recovered from 602 sample segments of C. inerme; 66 were purified. The 66 fungi belonging to 16 taxa and 11 genera (Alternaria, Nigrospora, Bartalinia, Pestalotiopsis, Fusarium, Mycoleptodiscus, Trichoderma, Phomopsis, Diaporthe, Lasiodiplodia, and Curvularia) were identified by morphological characteristics and fungal internal transcribed spacer sequences. The most abundant genera were Alternaria and Lasiodiplodia. Some of the endophytes exhibited tissue specificity. The colonization frequencies of endophytes in the stems were evidently higher than those in the roots and leaves. The crude ethyl acetate extracts were tested against 6 endophytes isolated from C. inerme. Three of 10 (33.3%) endophytes, which were identified as Phomopsis sp, Curvularia sp, and Mycoleptodiscus sp, displayed distinct antifungal activity against ≥3 tested fungi. To our knowledge, this is the first report of an endophytic community associated with C. inerme in China and its antifungal activity in vitro.

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Section: Isolation and Culture Of The Endophytic Fungimentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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“…Some examples are the new oxylipin and steroidal acetylcholinesterase inhibitors (Qiao et al, 2011); curvularin-type macrolides presenting antibacterial, antifungal and algicide properties (Dai et al, 2011), several classes of terpenes like the antimicrobial indoloterpenes (Qiao et al, 2010), sesquiterpenoids with antiplasmodial activity (Osterhage et al, 2002b), tetracyclic diterpenes (Gao et al, 2011a) and one antimicrobial monoterpene (Gao et al, 2011b cytotoxic steroids with tetrahydroxy and C-16-acetoxy groups (Gao et al, 2011c), antimicrobial and cytotoxic polyketides (Gao et al, 2011b), aromatic pentaketides of the dihydroisocoumarins class (Pontius et al, 2008a) and cytotoxic benzaldehyde derivatives (Wang et al, 2006).…”

Section: Endophytic Marine Microorganismsmentioning

confidence: 99%

Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi

Oliveira¹,

Felício²,

Debonsi³

2012

Rev. bras. farmacogn.

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Marine natural products have currently been recognized as the most promising source of bioactive substances for drug discovery research. In this review, extraordinary metabolites from marine algae species are illustrated, as well as approaches for their isolation and determination of their biological properties and pharmaceutical potential. Furthermore, marine endophytic microorganisms (from marine algae) are presented as a new subject for extensive investigation to find novel natural products, which make them a potentially rich and innovative source for new drug candidates.

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“…It is interesting that the three different strains also produced quite different families of antitumor compounds, i.e., benzaldehyde derivatives, cytochalasans and azaphilones [31][32][33][34].…”

Section: Relationship Between Systematics and Biological Potentialmentioning

confidence: 99%

Biological and chemical diversity of cytotoxin-producing symbiotic marine fungi in intertidal zone of Dalian

Zhang

Feng

et al. 2012

Chin. Sci. Bull.

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In this study, the biological and chemical diversity of 8 symbiotic marine fungal strains, with strong cytotoxicity against brine shrimp larvae, were investigated by nucleotide sequencing, morphology and cluster analysis of HPTLC fingerprint. These strains were identified by ITS rDNA sequencing, phylogenic analysis, and morphology to be Hypocrea lixii, Chaetomium globosum, Aspergillus fumigatus, Asp. clavatus and Alternaria sp. Their differences in secondary metabolites were shown by cluster analysis of digitalized colors of HPTLC spots, a newly developed method, which produced a similar dendrogram with that of ITS cluster analysis. Furthermore, this method can fully display intraspecific differences and even the remarkable difference in Aspergillus strains which goes beyond the boundary between genera. Their biological-chemical diversity may be the basis of their potent cytotoxicity and implies their potential in producing diversified antitumor or pesticidal constituents. Symbiotic fungi live on the surface or in the inner tissue of their hosts. Some terrestrial symbiotic fungi have been found to produce toxins or anti-feedants to protect their hosts from predators and grazers [1]. Some of these compounds can be used as antitumor or pesticidal agents. Symbiotic marine fungi have been isolated from seaweeds, sponges, corals, mangroves and sea grasses, also showing taxonomicall diversity and producing numerous active compounds [2]. The intertidal coastline of Dalian possesses diversified natural and artificial habitats and also high biodiversity of marine plants, invertebrates, and microorganisms. In our screening for useful cytotoxins from local symbiotic marine fungi using brine shrimp lethality test, a widely used bifunctional preliminary screening model to discover antitumor drugs and pesticides from the sea [3][4][5], eight strains with potent activities were discovered. Herein, we report the study on the biological and chemical diversity of these bioactive strains by ITS rDNA sequence analysis, morphology, and metabolite fingerprinting using a new cluster method.

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Chaetopyranin, a Benzaldehyde Derivative, and Other Related Metabolites from Chaetomium globosum, an Endophytic Fungus Derived from the Marine Red Alga Polysiphonia urceolata

Cited by 263 publications

References 22 publications

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi

Biological and chemical diversity of cytotoxin-producing symbiotic marine fungi in intertidal zone of Dalian

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