Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis

Shi, Jinyu; Hou, Jiqiu; Sun, Yize; Jia, Zihao; Zhou, Yue; Wang, Chao; Zhao, Haibin

doi:10.1016/j.biopha.2022.113437

Cited by 6 publications

(1 citation statement)

References 66 publications

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“…Renal artery and heart tissue paraffin sections were prepared by routine procedures [ 26 ]. In brief, renal artery and heart samples of rats ( n = 10 each) were isolated and fixed in 4% paraformaldehyde and then embedded in paraffin and sectioned at a thickness of 4 μ m. Renal artery sections were stained with hematoxylin-eosin (HE; G1005, Servicebio, Wuhan, China) and tyrosine hydroxylase (TH; ab137869, Abcam, MA, USA) according to standard protocol.…”

Section: Methodsmentioning

confidence: 99%

Effects of Renal Denervation on Ouabain‐Induced Hypertension in Rats

Tang,

Hu,

et al. 2024

International Journal of Hypertension

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Background. Ouabain, a Na+, K+‐ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS). Renal nerves play a vital role in the regulation of SNS activity, so we hypothesize that renal denervation may attenuate the development of ouabain‐induced hypertension. Methods and Results. Forty Sprague‐Dawley rats were divided into following groups (n = 10 each): control group (sham surgery plus intraperitoneal saline injection), RDN group (renal denervation (RDN) plus intraperitoneal saline injection), ouabain group (sham surgery plus intraperitoneal ouabain injection), and ouabain + RDN group (RDN plus intraperitoneal ouabain injection). After eight weeks, compared with the control group, rats in the ouabain group exhibited elevated blood pressure (P < 0.05), increased plasma epinephrine, norepinephrine, angiotensin II, and aldosterone levels (P < 0.05). These indexes could be significantly ameliorated by RDN. RDN also reduced the thickening of aortic tunica media and downregulated the expression of proliferating cell nuclear antigen (PCNA) in the thoracic aorta induced by ouabain. Masson staining and echocardiography showed that myocardial fibrosis and increased left ventricular mass in the ouabain group could be attenuated by RDN. Conclusions. The present study reveals that renal nerves play an important role in the development of ouabain‐induced hypertension. RDN could inhibit the pressor effect and the myocardial remodeling induced by ouabain potentially via inhibiting catecholamine release and vascular smooth muscle cell proliferation. Clinical studies are needed to explore whether RDN may exhibit better antihypertensive effects on hypertensive patients with high plasma ouabain levels as compared to those with normal plasma ouabain levels.

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Section: Methodsmentioning

confidence: 99%