“Chair stand testˮ as simple tool for sarcopenia screening in elderly women

Pinheiro, Paloma Andrade; Carneiro, José Ailton Oliveira; Coqueiro, Raildo Silva; Pereira, Rafael; Fernandes, Marcos Henrique

doi:10.1007/s12603-016-0676-3

Cited by 72 publications

(40 citation statements)

References 16 publications

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“…In the criteria, the initial assessment is grip strength, and patients with normal grip strength are classified as non‐sarcopenia without assessment of skeletal muscle mass. However, an impairment of physical function of the lower limbs is reported to be associated with sarcopenia . Thus, it seems to be important to evaluate muscle mass in CLD patients with impairment of lower limbs function, even when patients showed normal grip strength.…”

Section: Introductionmentioning

confidence: 99%

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Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Hirota

Kawaguchi

Koya

et al. 2019

Hepatology Research

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Aim Muscle atrophy is a prognostic factor for patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). The Liver Frailty Index (LFI) is a simple physical function test; however, an association between LFI and muscle mass remains unclear. We aimed to investigate the utility of LFI for predicting muscle atrophy in CLD patients with HCC. Methods We enrolled 138 CLD patients with HCC (aged 77 years, female/male 34.8%/65.2%). Muscle mass was assessed by skeletal muscle index, and patients were classified into the muscle atrophy group (n = 109) or the non‐muscle atrophy group (n = 29). Physical frailty was assessed by LFI. The optimal cut‐off value of LFI for predicting muscle atrophy was identified by receiver operating characteristic analysis. Results In the muscle atrophy group, the prevalence of pre‐frail/frail was significantly higher than the non‐muscle atrophy group (87.2% vs. 58.6%, P = 0.0005). In the logistic regression analysis, being female and pre‐frail/frail were identified as independent factors associated with muscle atrophy (pre‐frail/frail; OR 3.601, 95% CI 1.381–9.400, P = 0.0088). In patients with normal grip strength, 71.1% of patients were pre‐frail/frail, in which 82.8% of patients showed muscle atrophy. Receiver operating characteristic statistics provided an area under the curve of 0.74, and an LFI cut‐off value of 2.94 for predicting muscle atrophy (sensitivity 88.06%, specificity 52.17%, accuracy 77.91%). Conclusions We showed that pre‐frail/frail was an independent factor for muscle atrophy in CLD patients with HCC. Furthermore, LFI predicted muscle atrophy with high sensitivity, even in patients with normal grip strength. Thus, LFI might be a useful screening tool for muscle atrophy in CLD patients with HCC.

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Section: Introductionmentioning

confidence: 99%

“…However, an impairment of physical function of the lower limbs is reported to be associated with sarcopenia. 8 Thus, it seems to be important to evaluate muscle mass in CLD patients with impairment of lower limbs function, even when patients showed normal grip strength.…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Hirota

Kawaguchi

Koya

et al. 2019

Hepatology Research

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“…Therefore, the combination of upper and lower limb muscle strength testing might be necessary for adequately framing sarcopenia. The 5×STS is associated with many physical performance tests [54], progressive disability [53], and has been reported as a predictor of sarcopenia in older Brazilian women [55]. However, larger studies, also including older men, are needed to confirm and expand these initial findings.…”

Section: Imaging and Functional Markersmentioning

confidence: 93%

Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?

Picca

Calvani

Cesari

et al. 2020

IJMS

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Physical frailty and sarcopenia (PF&S) recapitulates all the hallmarks of aging and has become a focus in geroscience. Factors spanning muscle-specific processes (e.g., mitochondrial dysfunction in skeletal myocytes) to systemic changes (e.g., inflammation and amino acid dysmetabolism) have been pinpointed as possible contributors to PF&S pathophysiology. However, the search for PF&S biomarkers allowing the early identification and tracking of the condition over time is ongoing. This is mainly due to the phenotypic heterogeneity of PF&S, its unclear pathophysiology, and the frequent superimposition of other age-related conditions. Hence, presently, the identification of PF&S relies upon clinical, functional, and imaging parameters. The adoption of multi-marker approaches (combined with multivariate modeling) has shown great potential for addressing the complexity of PF&S pathophysiology and identifying candidate biological markers. Well-designed longitudinal studies are necessary for the incorporation of reliable biomarkers into clinical practice and for unveiling novel targets that are amenable to interventions.

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“…The Chair stand test was used to assess the lower extremities strength/endurance. During the test, the volunteers were instructed to cross their arms over their chest, and stand up and sit down five times from a chair as fast as possible, with time being measured in seconds 14 . Volunteers that completed the task in >60 seconds were considered incapable of performing the task and were excluded from statistical analysis.…”

Section: Lower Limb Strengthmentioning

confidence: 99%

Lower limb strength, but not sensorial integration, explains the age-associated postural control impairment

Andrade

Costa

Pirôpo

et al. 2017

MLTJ

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“Chair stand testˮ as simple tool for sarcopenia screening in elderly women

Abstract: The performance of "chair stand test" showed predictive ability for sarcopenia, being an effective and simple screening tool for sarcopenia in elderly women. This test could be used for screening sarcopenic elderly women, allowing early interventions.

Cited by 72 publications

References 16 publications

Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?

Lower limb strength, but not sensorial integration, explains the age-associated postural control impairment

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