“…Chalcones are used in several biosynthetic pathways as initial intermediate structures in the production of flavonoids, isoflavonoids, and aurones . A significant part of medicinal chemistry research in the 21st century has been focused on both natural and synthetic chalcones because of their various pharmacological potential including activities and characteristics such as antibacterial, − anti-inflammatory, − analgesic, , anticholinergic, antiplatelet, antiulcer, antioxidant, , antimalarial, anticancer, , antiviral, − antileishmanial, antidiabetic, , immunomodulatory, , aldose reductase inhibition, estrogenic, acetylcholinesterase inhibition, and as non-purine xanthine oxidase inhibitors . Chalcones are highly attractive molecules because of their simple structure, ease of construction, and promising biological applications.…”