Chalcones in Dermatology

Jumina,; Harizal,; Kurniawan, Yehezkiel Steven

doi:10.5772/intechopen.91145

Cited by 4 publications

(5 citation statements)

References 125 publications

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“…The shift of the C-6 protons of the mannopyranose rest to higher chemical shifts, specifically δ 4.85 (appearing as a multiplet, denoted as H-6a) and δ 4.81 (appearing as a multiplet, denoted as H-6b), compared to their initial values (~4.00 ppm in compound 6), indicated the attachment of the cinnamoyl group at the less hindered and more reactive position, namely, position 6. The remainder of the FTIR and 1 H-NMR spectra consistently matched the structure assigned to methyl 6-O-cinnamoyl-α-D-mannopyranoside (2) [22].…”

Section: Characterizationsupporting

confidence: 53%

“…13 C NMR (100 MHz, CDCl 3 ): δ C 165 22. (C 6 H 5 CH=CHCO-), 144.20, 143.26 (×3), 138.49 (×3), 128.25 (×3), 128.24 (×3), 125.45 (×3), 20.69, 20.66 {3 × p-CH 3 C 6 H 4 SO 2 -}, 150.71 (C 6 H 5 CH=CHCO-), 132.63, 132.41, 129.56 (×2), 129.11 (×2) (C 6 H 5 CH=CHCO-), 122.32 (C 6 H 5 CH=CHCO-), 97.25 (C-1), 72.11 (C-2), 71.32 (C-4), 70.71 (C-3), 69.49 (C-5), 63.13 (C-6), 55.46 (1-OCH 3 ), 14.20, 14.11, 14.04 {3 × p-CH 3 C 6 H 4 SO 2-}.…”

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confidence: 99%

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Exploring Cinnamoyl-Substituted Mannopyranosides: Synthesis, Evaluation of Antimicrobial Properties, and Molecular Docking Studies Targeting H5N1 Influenza A Virus

Akter,

Alhatlani,

Abdallah

et al. 2023

Molecules

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The pursuit of innovative combinations for the development of novel antimicrobial and antiviral medications has garnered worldwide interest among scientists in recent times. Monosaccharides and their glycosides, such as methyl α-d-mannopyranoside derivatives, play a significant role in the potential treatment of viral respiratory pathologies. This study was undertaken to investigate and assess the synthesis and spectral characterization of methyl α-d-mannopyranoside derivatives 2–6, incorporating various aliphatic and aromatic groups. The investigation encompassed comprehensive in vitro antimicrobial screening, examination of physicochemical properties, molecular docking analysis, molecular dynamics simulations, and pharmacokinetic predictions. A unimolar one-step cinnamoylation reaction was employed under controlled conditions to produce methyl 6-O-cinnamoyl-α-d-mannopyranoside 2, demonstrating selectivity at the C-6 position. This represented a pivotal step in the development of potential antimicrobial derivatives based on methyl α-d-mannopyranoside. Subsequently, four additional methyl 6-O-cinnamoyl-α-d-mannopyranoside derivatives were synthesized with reasonably high yields. The chemical structures of these novel analogs were confirmed through a thorough analysis of their physicochemical properties, elemental composition, and spectroscopic data. In vitro antimicrobial assays were conducted against six bacterial strains and two fungal strains, revealing promising antifungal properties of these methyl α-d-mannopyranoside derivatives in comparison to their antibacterial activity. Moreover, cytotoxicity testing revealed that the compounds are less toxic. Further supporting these findings, molecular docking studies were performed against the H5N1 influenza A virus, indicating significant binding affinities and nonbonding interactions with the target protein 6VMZ. Notably, compounds 4 (−7.2) and 6 (−7.0) exhibited the highest binding affinities. Additionally, a 100 ns molecular dynamics simulation was conducted to assess the stability of the complex formed between the receptor 6VMZ and methyl α-d-mannopyranoside derivatives under in silico physiological conditions. The results revealed a stable conformation and binding pattern within the stimulating environment. In silico pharmacokinetic and toxicity assessments of the synthesized molecules were performed using Osiris software (version 2.9.1). Compounds 4 and 6 demonstrated favorable computational and pharmacological activities, albeit with a low drug score, possibly attributed to their higher molecular weight and irritancy. In conclusion, this study showcases the synthesis and evaluation of methyl α-d-mannopyranoside derivatives as promising candidates for antimicrobial and antifungal agents. Molecular docking and dynamics simulations, along with pharmacological predictions, contribute to our understanding of their potential therapeutic utility, although further research may be warranted to address certain pharmacological aspects.

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Section: Characterizationsupporting

confidence: 53%

mentioning

confidence: 99%

Exploring Cinnamoyl-Substituted Mannopyranosides: Synthesis, Evaluation of Antimicrobial Properties, and Molecular Docking Studies Targeting H5N1 Influenza A Virus

Akter,

Alhatlani,

Abdallah

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Therefore, the selectivity of the HDS process is suboptimal, and it can damage aromatic hydrocarbon compounds in crude oil during the HDS of DBT. 16,17 In general, the ODS process is used to convert refractory thiophenic compounds, such as DBT, into sulfone and sulfoxide species. This is achieved using various oxidants, including H 2 O 2 , 18 molecular oxygen, 19 formic acid, 20 and ozone, 21 at atmospheric pressure and low temperatures (50−70 °C).…”

Section: Approaches For Desulfurizationmentioning

confidence: 99%

Assessment of Reaction Parameters in the Oxidative Desulfurization Reaction

Sahraei

2023

Energy Fuels

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Nowadays, the scientific community is actively researching the advancement of a sustainable effective desulfurization technique. The development of alternative or supplementary approaches to desulfurization has rapidly progressed in recent years. Among these approaches, the oxidative desulfurization (ODS) process stands out as a highly promising method. This can be attributed to its notable selectivity, cost-effectiveness, mild reaction conditions, and overall efficiency. It is essential to consider the role of oxidants, catalysts, and operating conditions in optimizing the ODS process. This review examines a comprehensive understanding of the ODS process and its potential applications in desulfurization. It highlights the importance of oxidants, extractant solvent, and other operating conditions in the ODS process and discusses the different groups of catalysts that can be used. In addition, the review examines five distinct groups of heterogeneous catalysts used in the ODS process: transition metal oxides stabilized, polyoxometalates, ionic liquids, carbon materials, and porous materials. The role of ionic liquids in catalytic and extractive oxidation is also explored. In recent years, alternative or supplementary desulfurization methods have been rapidly developed. The review discusses the advantages and disadvantages of each approach. It explores various techniques that can be employed to mitigate the drawbacks associated with each system.

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“…High [9,14,15 In recent times, the traditional technologies of HM remediation (Figure 1B) include physical methods (physical adsorption [24], leaching [25], and electrokinetic remediation [26]), chemical methods (flocculation precipitation [27], electrolysis [28], ion exchange adsorption [29] and chemical precipitation [30]), and biological methods (phytoremediation [31], microbial adsorption [32], microbial fuel cell [33] and biomineralization [34]). Among the proposed methods, biological or microbiological methods have the advantages of relative sustainability, environmental benignity, and low cost [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Bio-Remediation of Heavy Metal-Contaminated Soil by Microbial-Induced Carbonate Precipitation (MICP)—A Critical Review

et al. 2023

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Biomineralization processes utilizing microbial-induced carbonate precipitation (MICP) have recently shown promise as an effective approach for remediating heavy metal contamination. This article offers a comprehensive review of the latest research on MICP-mediated heavy metal remediation, with a focus on the characteristics of heavy metals in the treated environment, such as copper, cadmium, lead, nickel, zinc, chromium, and mixed heavy metals. The review summarizes experimental results from various heavy metals treated by MICP, including the enrichment and screening of new urease-positive bacteria, the mineral structure of different heavy metal precipitates, and the efficiency of the MICP technology. Recent advancements in the MICP technology regarding heavy metal removal, long-term stability, and practical applications are also discussed. Additionally, the limitations of the technique and existing solutions are reviewed. In addition, it provides insights on future directions for further research and development of the MICP approach for heavy metal remediation, in order to optimize the technique and improve its efficiency. Overall, the review highlights the potential of MICP as a viable method for heavy metal remediation, offering promising results for the removal of a variety of heavy metal contaminants from contaminated environments.

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Chalcones in Dermatology

Cited by 4 publications

References 125 publications

Exploring Cinnamoyl-Substituted Mannopyranosides: Synthesis, Evaluation of Antimicrobial Properties, and Molecular Docking Studies Targeting H5N1 Influenza A Virus

Exploring Cinnamoyl-Substituted Mannopyranosides: Synthesis, Evaluation of Antimicrobial Properties, and Molecular Docking Studies Targeting H5N1 Influenza A Virus

Assessment of Reaction Parameters in the Oxidative Desulfurization Reaction

Bio-Remediation of Heavy Metal-Contaminated Soil by Microbial-Induced Carbonate Precipitation (MICP)—A Critical Review

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