Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid

Sharma, Sumit; Singh, Samiksha

doi:10.1007/s11274-023-03587-3

Cited by 7 publications

(2 citation statements)

References 91 publications

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“…It has been reported that an initial enzymatic conversion from glucose to glucosone by pyranose oxidase and catalase in the presence of oxygen, followed by acetylation and deacetylation yield kojic acid. [31] Haliclonol, a tetrahydroderivative of kojic acid, was isolated for the first time in 1992 from the Caribbean sponge Haliclona hogarthi. [32] Since kojic acid is derived from D-glucose, and taking into account configurations of the two asymmetric carbons of haliclonol, which are the same as in this sugar, Dglucose probably is also the precursor of haliclonol.…”

Section: Resultsmentioning

confidence: 99%

Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia Umbellata

Santos Gusmão,

Silva Conceição,

Moreira de Queiros Santos

et al. 2024

Chemistry & Biodiversity

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Endophytic fungi live asymptomatically inside vegetal tissues, and such uncommon habitat contributes to their exceptional chemical diversity. Isolating natural products from endophytic fungi could fail due to silent biosynthetic gene clusters under ordinary in vitro culture conditions, and co‐culturing has been assayed to trigger their metabolism. We carried out single and dual cultures with 13 endophyte strains isolated from Euphorbia umbellata leaves. Multivariate statistics applied to untargeted metabolomics compared the chemical profiles of all endophyte cultures. PCA analysis guided the selection of the Aspergillus pseudonomiae J1 ‐ Porogramme brasiliensis J9 dual culture for its most significant chemical differentiation: Five compounds were putatively annotated in the J1‐J9 culture according to UHPLC‐HRMS data, kojic acid, haliclonol and its diastereoisomer, caffeic acid, and 2‐(3,4‐dihydroxyphenyl)acetaldehyde. Analysis by PLS‐DA using VIP score showed that kojic acid displayed the most significative importance in discriminating single and dual J1‐J9 cultures.

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Section: Resultsmentioning

confidence: 99%

Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia Umbellata

Santos Gusmão,

Silva Conceição,

Moreira de Queiros Santos

et al. 2024

Chemistry & Biodiversity

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“…Metabolic Engineering of KA Production in A. oryzae KA, a representative secondary metabolite produced by filamentous fungi, finds extensive applications in the cosmetics, pharmaceutical, and food industries. Chemically, it is a pyran-4-one with molecular formula C 6 H 6 O 4 , summarized in Figure 2A [38]. Using a three-step chemo-enzymatic route, Lassfolk et al realized the preparation of KA from Dglucose via glucosone [39], as depicted in Figure 2B.…”

Section: Cell Factory Of Producing Secondary Metabolite By a Oryzaementioning

confidence: 99%

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Sun,

Wu,

Long

et al. 2024

JoF

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Aspergillus oryzae, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits a robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as a cell factory for industrial enzyme production. Moreover, A. oryzae has the ability to synthesize various secondary metabolites, such as kojic acid and L-malic acid. Nevertheless, the complex secretion system and protein expression regulation mechanism of A. oryzae pose challenges for expressing numerous heterologous products. By leveraging synthetic biology and novel genetic engineering techniques, A. oryzae has emerged as an ideal candidate for constructing cell factories. In this review, we provide an overview of the latest advancements in the application of A. oryzae-based cell factories in industrial production. These studies suggest that metabolic engineering and optimization of protein expression regulation are key elements in realizing the widespread industrial application of A. oryzae cell factories. It is anticipated that this review will pave the way for more effective approaches and research avenues in the future implementation of A. oryzae cell factories in industrial production.

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Microbial Metabolites and Recent Advancement

Garia,

Chaubey,

Rawat

et al. 2024

Lecture Notes in Networks and Systems

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Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid

Cited by 7 publications

References 91 publications

Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia Umbellata

Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia Umbellata

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Microbial Metabolites and Recent Advancement

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