Challenges in developing a consensus definition of neonatal sepsis

McGovern, Matthew; Giannoni, Éric; Kuester, Helmut; Turner, Mark A.; Hoogen, Agnes van den; Bliss, Joseph M.; Koenig, Joyce M.; Keij, Fleur M; Mazela, Jan; Finnegan, Rebecca; Degtyareva, Marina; Simons, Sinno H P; Boode, Willem P. de; Strunk, Tobias; Reiss, Irwin K M; Wynn, James L.; Molloy, Eleanor J.; Infection, Inflammation

doi:10.1038/s41390-020-0785-x

Cited by 96 publications

(80 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They observed increase in IL-1β secretion capability in neonates born between 24 and 29 gestational weeks, beyond the first week of neonatal life [56]. Higher concentrations of IL-18 have also been observed in preterm neonates <28 gestational weeks compared to preterm neonates of 28–32 gestational weeks when the neonates presented with late-onset sepsis [57-59].…”

Section: Neonatal Inflammation Infection and The Inflammasomementioning

confidence: 99%

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

et al. 2020

Self Cite

View full text Add to dashboard Cite

Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.

show abstract

Section: Neonatal Inflammation Infection and The Inflammasomementioning

confidence: 99%

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Apart from mortality, it is associated with long-term consequences including impaired neurodevelopment [2]. A consensus definition for neonatal sepsis is lacking, but it is recognized as a systemic condition, with a dysregulated immune reaction in response to a pathogen, resulting in harmful hemodynamic changes and potential organ dysfunction [3,4].…”

Section: Introductionmentioning

confidence: 99%

Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis

Keij

Koch

Vigario

et al. 2021

J. Clin. Trans. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sepsis is one of the children’s leading cause of death worldwide [ 3 ], with a prevalence of 15.6% [ 4 , 5 ], and mortality rates of 9% to 20% [ 5 , 6 ]. It is estimated by the World Health Organization (WHO) that sepsis kills around 1 million newborns each year [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Development of an Immunochromatographic Strip Using Conjugated Gold Nanoparticles for the Rapid Detection of Klebsiella pneumoniae Causing Neonatal Sepsis

et al. 2021

View full text Add to dashboard Cite

Neonatal sepsis is a leading cause of death among newborns and infants, especially in the developing world. The problem is compounded by the delays in pinpointing the causative agent of the infection. This is reflected in increasing mortality associated with these cases and the spread of multi-drug-resistant bacteria. In this work, we deployed bioinformatics and proteomics analyses to determine a promising target that could be used for the identification of a major neonatal sepsis causative agent, Klebsiella pneumoniae. A 19 amino acid peptide from a hypothetical outer membrane was found to be very specific to the species, well conserved among its strains, surface exposed, and expressed in conditions simulating infection. Antibodies against the selected peptide were conjugated to gold nanoparticles and incorporated into an immunochromatographic strip. The developed strip was able to detect as low as 105 CFU/mL of K. pneumoniae. Regarding specificity, it showed negative results with both Escherichia coli and Enterobacter cloacae. More importantly, in a pilot study using neonatal sepsis cases blood specimens, the developed strip selectively gave positive results within 20 min with those infected with K. pneumoniae without prior sample processing. However, it gave negative results in cases infected with other bacterial species.

show abstract

Challenges in developing a consensus definition of neonatal sepsis

Cited by 96 publications

References 98 publications

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis

Development of an Immunochromatographic Strip Using Conjugated Gold Nanoparticles for the Rapid Detection of Klebsiella pneumoniae Causing Neonatal Sepsis

Contact Info

Product

Resources

About