Challenges in Nuclear Medicine: Innovative Theranostic Tools for Personalized Medicine

Kraeber-Bodéré, Françoise; Barbet, Jacques

doi:10.3389/fmed.2014.00016

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…As a consequence, one may benefit from this quantitative information to obtain metrics that may enhance (or probably replace) the visual interpretation that is still widely used in everyday clinical practice ( 6 ). In an interesting review, Tomasi and colleagues ( 7 ) advocate the use of quantitative metrics in PET for two main reasons: (i) those metrics are less user-dependent, calculated semi-automatically, and allow multi-center trials if acquisition and reconstruction parameters are carefully chosen ( 8 , 9 ), and (ii) the development of novel radiopharmaceuticals targeting relevant biomarkers ( 10 ) imposes the use of an optimal quantitative approach as conventional quantitative metrics (including visual analysis) may not always be adapted for extracting relevant information. Additionally, beyond the usefulness of quantitative imaging for therapy response or prognosis, those metrics are expected to play a pivotal role for tumor characterization in line with the development of personalized medicine.…”

Section: Introductionmentioning

confidence: 99%

State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET

Carlier

Bailly²

2015

Front. Med.

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18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) is an important tool in oncology. Its use has greatly progressed from initial diagnosis to staging and patient monitoring. The information derived from 18F-FDG-PET allowed the development of a wide range of PET quantitative analysis techniques ranging from simple semi-quantitative methods like the standardized uptake value (SUV) to “high order metrics” that require a segmentation step and additional image processing. In this review, these methods are discussed, focusing particularly on the available methodologies that can be used in clinical trials as well as their current applications in international consensus for PET interpretation in lymphoma and solid tumors.

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Section: Introductionmentioning

confidence: 99%

State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET

Carlier

Bailly²

2015

Front. Med.

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“…There are certain criteria to consider in the development and design of an optimal probe. Sufficient half-life and optimal energy of the radioisotopes have to be complementary to the selected probes for quality imaging [44]. For example, 68 Ga and 18 F for PET are radioisotopes with a short half-life utilized for imaging purposes with drugs that have fast distribution kinetics.…”

Section: Challenges Of Nuclear Imaging and The Role Of Nanomaterialsmentioning

confidence: 99%

Nanomaterial Probes for Nuclear Imaging

et al. 2022

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Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive imaging through the radioactive decay emission of the radionuclide. Nuclear imaging probes, commonly known as radiotracers, are radioisotope-labeled small molecules. Nanomaterials have shown potential as nuclear imaging probes for theranostic applications. By modifying the surface of nanomaterials, multifunctional radio-labeled nanomaterials can be obtained for in vivo biodistribution and targeting in initial animal imaging studies. Various surface modification strategies have been developed, and targeting moieties have been attached to the nanomaterials to render biocompatibility and enable specific targeting. Through integration of complementary imaging probes to a single nanoparticulate, multimodal molecular imaging can be performed as images with high sensitivity, resolution, and specificity. In this review, nanomaterial nuclear imaging probes including inorganic nanomaterials such as quantum dots (QDs), organic nanomaterials such as liposomes, and exosomes are summarized. These new developments in nanomaterials are expected to introduce a paradigm shift in nuclear imaging, thereby creating new opportunities for theranostic medical imaging tools.

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“…So only a few isotopes, for instance, 64 Cu, offer a combination of diagnostic and therapeutic capability. Secondly, phenotype-specific radiopharmaceutical is required for theranostic applications [109]. There are difficulties also related to dosimetry and delivery of the radionuclides to the target tissue.…”

Section: Theranostics Using Radioactive Isotopesmentioning

confidence: 99%

Secondary Radiation in Ion Therapy and Theranostics: A Review

Nandy

2021

Front. Phys.

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Ion therapy has emerged as one of the preferred treatment procedures in some selective indication of cancer. The actual dose delivered to the target volume may differ from the planned dose due to wrong positioning of the patient and organ movement during beam delivery. On the other hand, some healthy tissues outside the planned volume may be exposed to radiation dose. It is necessary to determine the primary particle range and the actual exposed volume during irradiation. Many proposed techniques use secondary radiation for the purpose. The secondary radiation consists mainly of neutrons, charged fragments, annihilation photons, among others, and prompt gammas. These are produced through nuclear interaction of the primary beam with the beam line and the patient’s body tissue. Besides its usefulness in characterizing the primary beam, the secondary radiation contributes to the risk of exposure of different tissues. Secondary radiation has significant contribution in theranostics, a comparatively new branch of medicine, which combines diagnosis and therapy. Many authors have made detailed study of the dose delivered to the patient by the secondary radiation and its effects. They have also studied the correlation of secondary charged particles with the beam range and the delivered dose. While these studies have been carried out in great detail in the case of proton and carbon therapy, there are fewer analyses for theranostics. In the present review, a brief account of the studies carried out so far on secondary radiation in ion therapy, its effect, and the role of nuclear reactions is given.

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Challenges in Nuclear Medicine: Innovative Theranostic Tools for Personalized Medicine

Cited by 11 publications

References 33 publications

State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET

State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET

Nanomaterial Probes for Nuclear Imaging

Secondary Radiation in Ion Therapy and Theranostics: A Review

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