Purpose of research: Conduct a comparative evaluation of the quality of life based on physical and psychological health of medical university students. Methods and materials of research: quality of life, health-related, were studied using questionnaires the SF-36 questionnaire from 333 students 1 and 5 courses, (1 year -133 respondents, the average age 18.02 + 0.5, 5 year -200 students, average age 22.4+0.8;). Results: The Level of physical functioning of 5th year students was significantly higher (PF 97.7+_10.8) than that of first year students (PF 81.5+_24.86) p < 0.001. Decrease of role physical functioning at students of 1 course (RF 70.11+-29.7) against ) at respondents of 5 course is established. Average pain intensity and General health have proved to be lower (BP 82,83-+17,56; GH 69.85-+15.03) compared with those of senior students (BP 87.57-+16.12; GH 79.37-+15.95), p < 0.001. The novelty of the research: An assessment of the gender characteristics of the self-assessment of the quality of life of students showed that female 5th-year students, compared with men, showed statistically significant high values of the variable of role-based physical functioning due to physical condition (p < 0.03), while among the interviewed first-year students, the components of physical and psychological components of health did not demonstrate a significant dependence on gender (p > 0.05).