Challenges of Pediatric Multisystem Inflammatory Syndrome Associated with Covid-19 - A Series of Clinical Cases

Revenco, Ninel

doi:10.31579/2692-9406/027

Cited by 3 publications

(3 citation statements)

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“…Multisystem inflammatory syndrome in adults (MIS-A) [2], SARS-CoV-2 liver infection [3]. In pediatrics Multisystem inflammatory syndrome in children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated with SARS-CoV-2 infection) [4,5], SARS-COV-2/ COVID-19 in children induce Kawasaki-Like Disease [6]. Neurological manifestations [7], recurrence of COVID-19 infection with meningitis without pulmonary involvement [8].…”

Section: Immunocompromised Chaos Develops Multisystem Inflammatory Sy...mentioning

confidence: 99%

Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

Vasilieva,

Vasiliev

2023

SJMAS

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According to the World Health Organization (WHO), coronavirus infection (COVID-19, (COronaVIrus Disease 2019) is an infectious disease caused by the SARS-CoV-2 virus [1]. SARS-CoV-2 virus, Severe Acute Respiratory Syndrome-related coronavirus 2. Initially considered pulmonary - respiratory pathology, then it turned out to be poly-systemic, with multi-inflammation of many other organs, and central nervous system. Multisystem inflammatory syndrome in adults (MIS-A) [2], SARS-CoV-2 liver infection [3]. In pediatrics Multisystem inflammatory syndrome in children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated with SARS-CoV-2 infection) [4,5], SARS-COV-2/ COVID-19 in children induce Kawasaki-Like Disease [6]. Neurological manifestations [7], recurrence of COVID-19 infection with meningitis without pulmonary involvement [8]. Brain damage in COVID is primarily neurological, as a material signaling pathway of inflammatory COVID-infection of cerebral vessels. This is important, from the release of these patients, from additional stress, suffering, stigmatization in society, their isolation, intimidation, coercion (bullying) with violation and restriction of their rights. Since, concomitantly with inflammatory lesions of many organs, cognitive deficits are a component of the post-acute consequences of COVID-19 (PASC), where the role of the kynurenine pathway is significant with temporary cognitive impairment [9]. The main pathway for the breakdown of tryptophan is an amino acid, without which the synthesis of serotonin is impossible, which controls the cycles of sleep and wakefulness, which is the precursor of the sleep hormone melatonin In patients with COVID-19, an imbalance of T-helpers 1 and 2 leads to a cytokine storm that can contribute to myocardial damage [10]. MIS is conditioned caused by immunocompromising (IC) CHAOS - [C]ardiovascular Compromise: shock; [H]omeostasis; [A]poptosis; [O]rgan Dysfunction; [S]uppression of the Immune System with the development of Systemic inflammatory response syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS) [11,12]. With pronounced multiple and other symptoms: Electro - Ion Membrane Distress Syndrome (Syndrome Maria & Irina Vasilieva) [13,14] with membrane manifestations of electrical storm or electromembrane paralysis; Capillary Leak Syndrome; Microcirculatory-Mitochondrial Distress Syndrom [15,16]. Also described: Overlap mechanisms of transient global amnesia and COVID-19 infection [17]; Hypokalemia-stroke mimic [18]; Differential diagnosis of cacosmia and dysgeusia in COVID-19 pandemic [19].

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Section: Immunocompromised Chaos Develops Multisystem Inflammatory Sy...mentioning

confidence: 99%

Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

Vasilieva,

Vasiliev

2023

SJMAS

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“…The most alarming complication of KD is aneurysmal dilatation of the coronary arteries, which can be detected by echocardiography starting from the 2nd week of the recovery stage [13]. Recently, several scientific journals have published a series of KB cases associated with SARS-CoV-2 infection, among which the cases are reported in the Republic of Moldova [3], Great Britain, Italy, France, USA, Turkey [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

SARS-COV-2/COVID19 Induce Kawasaki-Like Disease in Children Experience of Republic of Moldova: A Report of Five Cases

Revenco¹

2021

BRCR

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Infection with SARS-CoV-2 virus is a serious challenge for the entire medical and scientific community. Medical institutions are facing record numbers of patients and conflicting claims about SARS-CoV-2 and due to its mutagenic properties, thanks to the D614G protein from Coronavirus (CoV) defining the determines the mutagenicity of SARS - CoV and MERS-CoV [1,2]. With the expansion of the COVID-19 Pandemic, researchers have reported [3] clinical cases of multisystemic inflammatory syndrome in children (MIS-C), similar to Kawasaki disease (KD). Due to the absence of a diagnostic marker for KD, the latter is established according to the criteria of the American Society of Cardiology, in this situation with associated SARS-CoV-2 infection. We deem it appropriate to report five clinical cases of KD that met the criteria for defining an MIS-C case as defined by WHO.

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“…SARS-CoV-2 virus, Severe Acute Respiratory Syndrome-related coronavirus 2. α-Coronavirus (HCoV-229E) was discovered in the mid-1960s, β-Coronavirus A (HCoV-OC43) in 1967, β-Coronavirus B (SARS-CoV-1) in 2002, and HCoV-NL63 in 2004. In 2015, Middle East respiratory syndrome was caused by β-Coronavirus C (MERS-CoV), and in 2019, the COVID-19 pandemic was caused by β-Coronavirus B (SARS-CoV-2) [1][2][3][4][5][6][7][8][9][10][11].…”

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confidence: 99%

Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus

Vasilieva,

Vasiliev

2024

SJMAS

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Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of the virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores the role of Acute Vascular Distress Syndrome (AVDS) in the development of MIS in both adults (MIS-A) and children (MIS-C), providing a comprehensive overview of modern research and treatment approaches for severe coronavirus infections. Methods and Materials: This review synthesizes findings from multiple studies and clinical reports to analyze the mechanisms by which SARS-CoV-2 induces AVDS and subsequently MIS. Key materials include molecular and cellular research data, clinical case studies, and treatment protocols. Diagnostic tools such as PCR and serological testing, as well as various biomarkers like neurofilament light chain and galectin-3, are discussed to elucidate their roles in identifying and managing severe COVID-19 cases. Results: The interaction between SARS-CoV-2 and host endothelial cells, mediated by ACE2 receptors, triggers a cascade of inflammatory responses leading to AVDS. This syndrome is characterized by severe endothelial dysfunction, cytokine storms, and mitochondrial distress, which collectively contribute to the pathogenesis of MIS. Clinical evidence indicates that AVDS is a critical factor in the severity of COVID-19, with widespread implications for multiple organ systems, including the central and peripheral nervous systems. Conclusion: Understanding the role of AVDS in MIS development offers valuable insights into the pathophysiology of severe COVID-19. Effective management requires a multifaceted approach, combining antiviral therapies, immunomodulators, and supportive treatments like extracorporeal membrane oxygenation (ECMO). Future research should focus on targeted therapies to mitigate endothelial damage and improve patient outcomes in critical COVID-19 cases.

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Challenges of Pediatric Multisystem Inflammatory Syndrome Associated with Covid-19 - A Series of Clinical Cases

Cited by 3 publications

References 0 publications

Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

SARS-COV-2/COVID19 Induce Kawasaki-Like Disease in Children Experience of Republic of Moldova: A Report of Five Cases

Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus

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