The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.

Background: In the current proposal, we used the intralipid in standard therapy against COVID / 19 as an energy carrier for parenteral nutrition in critically ill patients. In patients receiving intralipid, there was an accelerated recovery of the lungs, a decrease in markers of endogenous intoxication (EI), tissue hypoxia and an improvement in general condition. In the absence of Intralipid in the intensive care unit, there was a slow recovery of the lungs and a more prolonged improvement in the general condition with the preservation of EI markers (cytolytic enzymes, C-reactive protein, platelets) and tissue hypoxia (pCO2 AV> 6 mm Hg). Collectively, Intralipid has been seen in the targeted LPO treatment plan for oxidative and nitro-galogenic stress in SARS-Cov2 / COVID / 19 patients.

Results 480 biomarker assays were performed in 80 samples from ten infants. OI correlated positively with BNP, NTproBNP, and VEGF-A, and negatively with PLGF (Table 1). PH measures correlated negatively with PLGF and positively with NTproBNP and Troponin1. Measures of diastolic function correlated negatively with Troponin1 and VEGF-A, and positively with PLGF. Conclusions 1) Plasma biomarker analysis is feasible in infants with PH in CDH. 2) Worsening disease status (impaired oxygenation, PH, diastolic dysfunction) was associated with elevated BNP, NTproBNP, Troponin1 and VEGF-A, and reduced PLGF. 3) The utility of these peptides as disease biomarkers, prognostic indicators, and their role in disease pathogenesis merits further investigation.

Syndrome métabolique chez l'enfantIntroduction. L'augmentation alarmante du syndrome métabolique (SM) chez les enfants dans le monde entier a fait de la prévention et du traitement précoce de l'obésité un objectif médical important. L'objectif de l'étude a été d'evaluer le rôle des marqueurs pro-inflammatoires (IL-6, TNF , hs-PCR) et adipokines (leptine, adiponectine) dans le développement du syndrome métabolique chez les enfants et impacts du traitement par inhibiteurs gastro-intestinaux de la lipase sur le degré d'obésité et les valeurs de la pression artérielle. Matériel et méthodes. L'étude a inclus 24 enfants atteints du syndrome métabolique. Les niveaux sériques de lépine, adiponectine, TNF- et hs-CRP ont été mésurés chez les enfants atteints du SM par rapport à un groupe témoin de 50 enfants d'âge similaire, normotendus et de poids normal. On a également examiné l'impact du traitement par des inhibiteurs de la lipase gastro-intestinale sur l'obésité et sur les valeurs de la pression artérielle. Résultats. Le taux sérique de leptine, de hs-CRP, de TNF- s'est avéré plus élevé, et celui de l'adiponectine plus faible chez les enfants atteints de SEP, par rapport au groupe témoin. Après huit semaines de traitement

Background According to the first SARS-CoV-2 pandemic data, signs and symptoms were less frequently reported among pediatric patients versus adults. Later in April, was described as the multisystem inflammatory syndrome in children (MIS-C) associated with COVID -19. The clinical presentation of MIS-C includes fever, simultaneous involvement of two or more organ systems, altered inflammation parameters and laboratory or epidemiological evidence of SARS-CoV-2 infection. MIS-C features some similar clinical aspects with Kawasaki disease, toxic shock syndrome, and secondary hemophagocytic lymph histiocytosis syndrome / macrophage activation syndrome. This review describes the clinical features of 7 cases of MIS-C treated in the Republic of Moldova.