Challenging multidrug-resistant urinary tract bacterial isolates via bio-inspired synthesis of silver nanoparticles using the inflorescence extracts of Tridax procumbens

Al-Ansari, Mysoon M.; Dhasarathan, P.; Ranjitsingh, A. J. A.; Al-Humaid, Latifah

doi:10.1016/j.jksus.2020.08.028

Cited by 13 publications

(6 citation statements)

References 27 publications

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“… 25 The microbial pathogens of UTI have become more resistant to many antibiotics due to the wrong use in treatment, as well as the development and virulence of the pathogen cells. 26 Furthermore, pathogenic bacterial cells have the ability to generate biofilms that protect them from therapeutic medications. 27 Therefore, it has become necessary for those interested in scientific research and scientists to devise modern strategies capable of eliminating the pathogens of UTI.…”

Section: Introductionmentioning

confidence: 99%

Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism

et al. 2022

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“…The electric potential at the boundary of the double layer is referred to as the zeta potential of the particles. The surface charge over the nanoparticles gives stability to the nanoparticles and avoids agglomeration [ 46 ]. From Figure 4(c) , it was inferred that TNP has a zeta potential of -20.7 mV, which indicates the stability of the TNP.…”

Section: Resultsmentioning

confidence: 99%

“…From Figure 4(c) , it was inferred that TNP has a zeta potential of -20.7 mV, which indicates the stability of the TNP. However, the obtained TNP was more stable than the silver nanoparticles previously synthesized from the inflorescence of T. procumbens , with the average zeta potential value being -32.3 mV [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similar results for aqueous leaf extracts were reported, and the zone of inhibition was measured for E. coli (14 mm), Pseudomonas aeruginosa (10 mm), Aeromonas spp. (15 mm), and Proteus mirabilis (10 mm), which were the standard laboratory cultures [ 46 ]. We made use of MDR clinical isolates obtained from clinical specimens obtained from a human source [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

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Green Synthesis of Silver Nanoparticles Using the Tridax procumbens Plant Extract and Screening of Its Antimicrobial and Anticancer Activities

Pungle

Nile

Makwana

et al. 2022

Oxidative Medicine and Cellular Longevity

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In this study, we report the green synthesis of silver nanoparticles (AgNPs) using the aqueous leaf extract of Tridax procumbens (TNP), which acts as the source of the reducing and capping agent. The distinctive absorption at 370 nm suggested synthesis of TNPs, which was confirmed by TEM, with a size in the range of 11.1 nm to 45.4 nm and a spherical shape, having a face-centered cubic structure, analyzed by XRD, and a Zeta potential of -20.7 mV, which indicated a moderate stability of TNP. The FTIR analysis revealed the presence of amines and hydroxyl groups with fluoro compounds over the TNPs. The HRLC-MS analysis of TNPs suggested the presence of a major capping agent such as fosinopril and reducing agents such as peptides (Gln Gly Ala, Ser Pro Asn, and Leu Met), terpenoids (lupanyl acid, tiamulin), polyphenol (peucenin), and alkaloids (8 ′ ,10 ′ -dihydroxydihydroergotamine, carteolol). The synthesized silver nanoparticles exhibited antimicrobial activity against multidrug-resistant (MDR) clinical isolates (Escherichia coli, Shigella spp., Aeromonas spp., Pseudomonas aeruginosa, and Candida tropicalis) and had anticancer activity against A459 (IC50 42.70 μg/ml). The extraction of partially purified aqueous leaf extracts by silica gel column chromatography followed by HPLC to synthesize silver nanoparticles (TNP11) and analyzed by HRLC-MS suggested that dipeptides were involved in the reduction of Ag+ to Ag0. Overall, the results showed that the green silver nanoparticles of T. procumbens could be safe, as they are endowed with potential antimicrobial activity against MDR clinical isolates and human lung carcinoma cells.

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“…Among the severa of metallic NPs, the mechanism of some of the new NPs is still not understood [11 The mechanisms employed by metallic NPs to exert antimicrobial activities are pr in Figure 2. Examples of metallic-based NPs with antimicrobial properties includ Ag-, Au-, Ag oxide-, titanium dioxide-, aluminum oxide-, copper oxide-, an um-based NPs [123,124].…”

Section: Metallic Nps With Antimicrobial Activitymentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

et al. 2021

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The diagnosis and treatment of urinary tract infections (UTIs) remain challenging due to the lack of convenient assessment techniques and to the resistance to conventional antimicrobial therapy, showing the need for novel approaches to address such problems. In this regard, nanotechnology has a strong potential for both the diagnosis and therapy of UTIs via controlled delivery of antimicrobials upon stable, effective and sustained drug release. On one side, nanoscience allowed the production of various nanomaterial-based evaluation tools as precise, effective, and rapid procedures for the identification of UTIs. On the other side, nanotechnology brought tremendous breakthroughs for the treatment of UTIs based on the use of metallic nanoparticles (NPs) for instance, owing to the antimicrobial properties of metals, or of surface-tailored nanocarriers, allowing to overcome multidrug-resistance and prevent biofilm formation via targeted drug delivery to desired sites of action and preventing the development of cytotoxic processes in healthy cells. The goal of the current study is therefore to present the newest developments for the diagnosis and treatment of UTIs based on nanotechnology procedures in relation to the currently available techniques.

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Challenging multidrug-resistant urinary tract bacterial isolates via bio-inspired synthesis of silver nanoparticles using the inflorescence extracts of Tridax procumbens

Cited by 13 publications

References 27 publications

Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism

Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism

Green Synthesis of Silver Nanoparticles Using the Tridax procumbens Plant Extract and Screening of Its Antimicrobial and Anticancer Activities

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

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