Challenging the Efficient Frontier Portfolio

Steinbacher, Matjaz; Steinbacher, Matej; Steinbacher, Mitja

doi:10.2139/ssrn.1603926

Cited by 6 publications

(10 citation statements)

References 55 publications

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“…Interestingly, this conformational change leaves the remaining substrate-binding pockets unaffected. 133 Notably, two divalent ions are also present as they contribute to substrate alignment and are required for facilitating catalysis. They include Zn 2+ , with tetrahedral coordination, and Mn 2+ or, under physiological conditions, Mg 2+ , with octahedral coordination.…”

Section: C-methyl-d-erythritol 24-cyclodiphosphate Synthase (Ispf)mentioning

confidence: 99%

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Wang

Dowd

2018

ACS Infect. Dis.

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a severe infectious disease in need of new chemotherapies especially for drug-resistant cases. To meet the urgent requirement of new TB drugs with novel modes of action, the TB research community has been validating numerous targets from several biosynthetic pathways. The methylerythritol phosphate (MEP) pathway is utilized by Mtb for the biosynthesis of isopentenyl pyrophosphate (IPP) and its isomer dimethylallyl pyrophosphate (DMAPP), the universal five-carbon building blocks of isoprenoids. While being a common biosynthetic pathway in pathogens, the MEP pathway is completely absent in humans. Due to its unique presence in pathogens as well as the essentiality of the MEP pathway in Mtb, the enzymes in this pathway are promising targets for the development of new drugs against tuberculosis. In this Review, we discuss three enzymes in the MEP pathway: 1-deoxy-d-xylulose-5-phosphate synthase (DXS), 1-deoxy-d-xylulose-5-phosphate reductoisomerase (IspC/DXR), and 2 C-methyl-d-erythritol 2,4-cyclodiphosphate synthase (IspF), which appear to be the most promising antitubercular drug targets. Structural and mechanistic features of these enzymes are reviewed, as well as selected inhibitors that show promise as antitubercular agents.

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Section: C-methyl-d-erythritol 24-cyclodiphosphate Synthase (Ispf)mentioning

confidence: 99%

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Wang

Dowd

2018

ACS Infect. Dis.

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“…This is a system, introduced in 1957, in which the concept to prevent equipment failures is further expanded to be applied to the improvement of equipment so that the equipment failure can be eliminated (improving the reliability) and the equipment can be easily maintained (improving equipment maintainability) (Steinbacher and Steinbacher, 1993). The primary difference between corrective and PM is that a problem must exist before corrective actions are taken (Higgins et al, 1995).…”

Section: Corrective Maintenancementioning

confidence: 99%

“…Introduced in 1960s, this is an activity, wherein, the equipment is designed such that they are maintenance free and an ultimate ideal condition of "what the equipment and the line must be" is achieved (Steinbacher and Steinbacher, 1993). In the development of new equipment, MP initiatives must start at the design stage and should strategically aim at ensuring reliable equipment, easy to care for and user friendly, so that operators can easily retool, adjust, and otherwise run it (Shirose, 1992).…”

Section: Maintenance Preventionmentioning

confidence: 99%

Evaluating exploits of Indian entrepreneurs through maintenance practices for realising the overall organisational goals and objectives

Singh

Ahuja

2017

IJPMB

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Until very recently, maintenance management was more of a traditional skill-based management discipline which depended on experience, guts and luck. Today, the question 'Is change in maintenance management necessary?' is increasingly being asked. The continual modernisation and the pressing need for higher productivity have resulted in the increased development and use of sophisticated and complex machines and equipment. Moreover, maintenance processes can be streamlined to eliminate waste and produce breakthrough performance in areas valued by customers. The research has been carried out in the small and medium scale manufacturing organisations in the country, to study the maintenance related issues and achievements realised as a result of synergistic implementation of maintenance practices. The approach of the study has been directed towards justification of maintenance practices for their support to competitive manufacturing in the Indian industry. The study has been focused upon evaluating exploits of Indian entrepreneurs with maintenance practices, for realising the overall organisational goals and objectives.

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“…Dabei wird überschüssige thermische Energie aus solarthermischen Anlagen in einem in seiner Bauart neuartigen Direktkontakt‐Latentwärmespeicher (Speichermedium: Phasenwechselmaterial ( phase change material , PCM) mit einem Fest/Flüssig‐Phasenübergang) gespeichert. Der Speicher wurde vom Institut für Prozessmesstechnik und innovative Energiesysteme der Hochschule Mannheim in Zusammenarbeit mit der Technischen Universität Berlin und der Bundeswehr entwickelt und in seiner Bauart patentiert . Speziell das hier vorgestellte und diskutierte Speicherkonzept trägt stark zur Effizienzsteigerung des Systems durch bessere Ausnutzung der erneuerbaren Energien bei und unterscheidet sich stark von den konventionellen Wasserspeichern.…”

Section: Introductionunclassified

“…Im vorliegenden Beitrag wird die Differierung von zu den literaturbekannten Direktkontakt‐Latentwärmespeichern dargestellt. Die allgemeinen Vorteile des Latentwärmespeichers gegenüber einem sensiblen Speicher, wie ein gleichbleibendes Temperaturniveau bei der Energieentnahme und eine höhere Energiedichte insb.…”

Section: Introductionunclassified

Direct Contact Latent Heat Storage for Efficiency Enhancement of Heat Pumps

Kunkel

Kübel‐Heising

Dörnhofer

et al. 2017

Chemie Ingenieur Technik

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Direct Contact Latent Heat Storage for Efficiency Enhancement of Heat PumpsWith an innovative concept for the storage of thermal energy at low and constant temperature levels, solar thermal energy can be used effectively in transition and winter periods. Furthermore, the solar energy can be stored to increase the efficiency of heat pumps. A latent heat storage system based on salt hydrates is introduced, where the salt hydrate has a melting point of 15°C and is in direct contact with an immiscible heat transfer fluid generating a high charging and discharging capacity. Initial experimental results and application examples are presented and discussed.

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Challenging the Efficient Frontier Portfolio

Cited by 6 publications

References 55 publications

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Evaluating exploits of Indian entrepreneurs through maintenance practices for realising the overall organisational goals and objectives

Direct Contact Latent Heat Storage for Efficiency Enhancement of Heat Pumps

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