Challenging Treatment of an Infected <scp>C</scp>ircuLite <scp>S</scp>ynergy Micropump After Pump Thrombosis Due to Subtherapeutic Anticoagulation Therapy: Pushing the Limits?

Bireta, Christian; Danner, Bernhard C.; Grossmann, Marius; Zenker, Dieter; Seidler, Tim; Unsöld, Bernhard; Sabashnikov, Anton; Mühlhäuser, Ulrike; Bräuer, Anselm; Schöndube, Friedrich A.; Popov, Aron Frederik

doi:10.1111/aor.12273

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Nevertheless, as described in previous research and confirmed by our experience, the Synergy pump exchange can be performed more easily and quickly than a full-support LVAD, similar to a pacemaker exchange, even in difficult clinical settings, because neither sternotomy nor inflow/outflow cannulae exchange is needed. 13 In general, our outcomes with partial support are similar to those described in previous studies of patients for whom the Synergy device was originally intended, that is, lessadvanced heart failure. However, in our patient cohort, there may be a relatively high risk of the requirement for an upgrade to a full-support device because of late deterioration in hemodynamics and clinical condition.…”

Section: Discussionsupporting

confidence: 83%

Outcomes after implantation of partial-support left ventricular assist devices in inotropic-dependent patients: Do we still need full-support assist devices?

Sabashnikov

Popov

Bowles

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Partial LVAD support may be clinically efficacious in inotropic and intra-aortic balloon pump-dependent patients. On the basis of our experience and evidence of previous research, such patients may benefit from minimally invasive access, no need for sternotomy and cardiopulmonary bypass, a short implantation time, an easy exchange if necessary, and a lower risk of subsequent heart transplantation. Because the implantation is performed without sternotomy, device upgrade is feasible with a comparatively low operative risk and good clinical outcome. Our preliminary results show that partial-support devices may have the potential to replace full-support LVADs in the near future.

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Section: Discussionsupporting

confidence: 83%

Outcomes after implantation of partial-support left ventricular assist devices in inotropic-dependent patients: Do we still need full-support assist devices?

Sabashnikov

Popov

Bowles

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Artificial hearts—recent progress: republication of the article published in the Japanese Journal of Artificial Organs

Nishida

2017

J Artif Organs

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Does CircuLite Synergy assist device as partial ventricular support have a place in modern management of advanced heart failure?

Mohite¹,

Sabashnikov²,

Simon³

et al. 2014

Expert Review of Medical Devices

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The discrepancy between the number of patients on the waiting list and available donor hearts has led to the successful development of left ventricular assist devices (LVAD) as a bridge to transplantation. The conventional LVADs are designed to provide full hemodynamic support for the end-stage failing heart. However, full-support LVAD implantation requires major surgery, sternotomy and cardiopulmonary bypass in majority of cases. The Synergy Micro-pump is the smallest implantable LVAD and provides partial flow support up to 3 l/min. It was shown that early intervention with this device can provide substantial benefits to patients with severe heart failure not yet sick enough for a full-support LVAD. Due the small dimensions it can be implanted without cardiopulmonary bypass or a sternotomy. The purpose of this article is to review the clinical use of the Synergy Micro-pump as partial hemodynamic support.

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Challenging Treatment of an Infected CircuLite Synergy Micropump After Pump Thrombosis Due to Subtherapeutic Anticoagulation Therapy: Pushing the Limits?

Cited by 4 publications

References 7 publications

Outcomes after implantation of partial-support left ventricular assist devices in inotropic-dependent patients: Do we still need full-support assist devices?

Outcomes after implantation of partial-support left ventricular assist devices in inotropic-dependent patients: Do we still need full-support assist devices?

Artificial hearts—recent progress: republication of the article published in the Japanese Journal of Artificial Organs

Does CircuLite Synergy assist device as partial ventricular support have a place in modern management of advanced heart failure?

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