Change in Antibiotic Sensitivity Pattern of Klebsiella pneumoniae: A Two and Half Year Study

Shah, Krunal; Hemachander, Suguna S; Lakhani, Sucheta; Khara, Radhika

doi:10.20546/ijcmas.2016.509.061

Cited by 2 publications

(3 citation statements)

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“…In the present study, resistance pattern was studied in SSI patients. [ 8 9 10 ] A total of 451 isolates were found in the patients who had SSI after discharge, and a very high number of SSI isolates ( n = 1996) were reported in the admitted patients. Similarly, we have reported the difference in antibiotic-resistant in SSI group of patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] Antimicrobial resistance is spreading rapidly among the bacterial population which further made the treatment difficult and challenging especially in surgical and clinical practice. [ 9 ] SSI are still remains the major problem in clinical practices and further considering the high level of resistance pattern in SSI patients,[ 1 10 ] it is becoming important to identify the resistant pattern among these SSI cases. Most of the studies were evaluated the resistance pattern of the organisms in SSI cases till the hospital stay only but as most of the infections emerges after the discharge which could be community acquired once the patient was discharged from the hospital.…”

Section: Introductionmentioning

confidence: 99%

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Pattern of antimicrobial resistance of Gram-negative bacilli in surgical site infections in in-patients and out-patients at an apex trauma Center: 2013–2016

et al. 2018

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INTRODUCTION: Antimicrobial resistance is an increasing problem worldwide especially among the surgical site infections (SSIs). SSI is becoming more serious due to hospital-acquired infections/nosocomial infections, which further leads to the overuse of broad-spectrum antibiotics. To investigate the antimicrobial resistance patterns among Gram-negative bacteria in SSI in in- and out-patients the present study was designed. METHODOLOGY: During the 4 years (January 2013–December 2016), the antimicrobial resistant pattern was studied in the admitted patients and in the patients who were followed up to the outpatients department (OPD) after discharge. Antimicrobial resistance pattern testing was done by the disk diffusion method on Mueller-Hinton agar and by E-test for ten antibiotics according to The Clinical and Laboratory Standards Institute guidelines for Gram-negative bacilli. RESULTS: A total of 2,447 strains were isolated from the studied population on over the period of 4 years. Of 2447, 1996 (81%) were isolated from patients who had SSI during the hospital stay, and 451 (18%) were from patients who attended the OPD after discharge. In the outpatients, who followed up in the OPD for the SSI, Escherichia coli (148), and Pseudomonas aeruginosa (93), whereas in the patients who develop SSI during their hospital stay, Acinetobacter baumannii (622), E. coli (424), and Klebsiella pneumoniae (315) were found to be common. A very high resistance pattern was observed in both the studied groups; however, a higher resistance pattern was seen in in-patients as compared to outpatients. CONCLUSION: In our study, we have reported resistance pattern in Gram-negative bacteria isolated from the patients who were came for the follow as well as in the inpatients. For the outpatients, it can be concluded that it could be a community-acquired infection which is also an alarming condition for our society.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pattern of antimicrobial resistance of Gram-negative bacilli in surgical site infections in in-patients and out-patients at an apex trauma Center: 2013–2016

et al. 2018

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“…The mainstay of adequate therapy is the early diagnosis of SSI and microbiological diagnostics [91]. Identification of the resistance patterns among SSI cases is crucial [95, 96] in order to avoid the misuse and abuse of antibiotics especially broad-spectrum drugs adding to the economic burden of the disease [56]. Studies have shown differences in the virulence of bacteria among outpatient compared with inpatient settings where inpatients population had a higher number of resistant organisms causing SSI [46, 97].…”

Section: Resultsmentioning

confidence: 99%

Highlighting the gaps in quantifying the economic burden of surgical site infections associated with antimicrobial-resistant bacteria

Iskandar

Sartelli

Tabbal³

et al. 2019

World J Emerg Surg

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Antibiotics are the pillar of surgery from prophylaxis to treatment; any failure is potentially a leading cause for increased morbidity and mortality. Robust data on the burden of SSI especially those due to antimicrobial resistance (AMR) show variable rates between countries and geographical regions but accurate estimates of the incidence of surgical site infections (SSI) due to AMR and its related global economic impact are yet to be determined. Quantifying the burden of SSI treatment is an incentive to sensitize governments, healthcare systems, and the society to invest in quality improvement and sustainable development. However in the absence of a unified epidemiologically sound infection definition of SSI and a well-designed global surveillance system, the end result is a lack of accurate and reliable data that limits the comparability of estimates between countries and the possibility of tracking changes to inform healthcare professionals about the appropriateness of implemented infection prevention and control strategies. This review aims to highlight the reported gaps in surveillance methods, epidemiologic data, and evidence-based SSI prevention practices and in the methodologies undertaken for the evaluation of the economic burden of SSI associated with AMR bacteria. If efforts to tackle this problem are taken in isolation without a global alliance and data is still lacking generalizability and comparability, we may see the future as a race between the global research efforts for the advancement in surgery and the global alarming reports of the increased incidence of antimicrobial-resistant pathogens threatening to undermine any achievement.

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Change in Antibiotic Sensitivity Pattern of Klebsiella pneumoniae: A Two and Half Year Study

Cited by 2 publications

References 9 publications

Pattern of antimicrobial resistance of Gram-negative bacilli in surgical site infections in in-patients and out-patients at an apex trauma Center: 2013–2016

Pattern of antimicrobial resistance of Gram-negative bacilli in surgical site infections in in-patients and out-patients at an apex trauma Center: 2013–2016

Highlighting the gaps in quantifying the economic burden of surgical site infections associated with antimicrobial-resistant bacteria

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