Change in cutaneous perfusion following 10 weeks of aerobic training in Type 2 diabetes

Colberg, Sheri R.; Parson, Henri K.; Nunnold, Tanja; Holton, D. Robb; Swain, David P.; Vinik, Aaron I.

doi:10.1016/j.jdiacomp.2005.02.006

Cited by 40 publications

(29 citation statements)

References 41 publications

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“…2 Erythrocyte flux response to ACh in the control group at baseline (triangles) and 6 months (crosses). Error bars are SD maximum skin microvascular hyperaemia or interstitial nitric oxide levels [24]. The effects of prolonged exercise training on microvascular function had not been investigated prior to the current study in type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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Aims/hypothesis Adults with type 2 diabetes mellitus have impaired microvascular function. It has been hypothesised that microvascular function may be restored through regular exercise. The aim of this study was to investigate whether 6 months of regular aerobic exercise would improve microvascular function in adults with type 2 diabetes. Materials and methods Fifty-nine patients with type 2 diabetes (32 males, age 62.9±7.6 years, HbA 1c 6.8±0.9%) were randomised to either a 6-month aerobic exercise programme (30 min, three times a week, 70-80% of maximal heart rate) or a 'standard care' control group. Before and after the intervention period, microvascular function was assessed as the maximum skin hyperaemia to local heating and endothelial and non-endothelial responsiveness following the iontophoretic application of acetylcholine and sodium nitroprusside. Maximal oxygen uptake, as an index of aerobic fitness, was assessed using a maximal exercise test.

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Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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“…Furthermore, many studies have established an impairment of endothelium-dependent vasodilation in human skin microcirculation with aging (Black et al, 2008;Holowatz et al, 2007) and in disease (Colberg et al, 2005;Rossi et al, 2011;Taddei et al, 2006). Nevertheless, the exact contribution of various endothelial vasodilators to endothelium-mediated vasodilation has to be elucidated as the results are discrepant.…”

Section: Human Skin Microcirculation and The Endothelium: Impact Of Nmentioning

confidence: 99%

“…In general, the collective finding is that regular physical exercise enhances endothelium-dependent vasodilation. Moreover, it has been shown that exercise also improves the decline of endothelium-dependent vasodilation of cutaneous microcirculation in age (Black et al, 2008) and disease (Colberg et al, 2005;Rossi et al, 2011;Taddei et al, 2006).…”

Section: Exercise Augments the Endothelium Dependent Vasodilation In mentioning

confidence: 99%

Assessment of Human Skin Microcirculation and Its Endothelial Function Using Laser Doppler Flowmetry

Lenasi¹

2011

Medical Imaging

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“…The methods used to measure SkBF have been previously described (15)(16)(17). Briefly, laser Doppler probes were positioned 10 cm below the knee and 10 cm above the malleolus in a thermoneutral (25°C) laboratory environment.…”

Section: Efficacy Measurementsmentioning

confidence: 99%

A 6-Month, Randomized, Double-Masked, Placebo-Controlled Study Evaluating the Effects of the Protein Kinase C-β Inhibitor Ruboxistaurin on Skin Microvascular Blood Flow and Other Measures of Diabetic Peripheral Neuropathy

et al. 2007

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OBJECTIVE -Diabetes leads to protein kinase C (PKC)-␤ overactivation and microvascular dysfunction, possibly resulting in disordered skin microvascular blood flow (SkBF) and other changes observed in diabetic peripheral neuropathy (DPN) patients. We investigate the effects of the isoform-selective PKC-␤ inhibitor ruboxistaurin mesylate on neurovascular function and other measures of DPN.RESEARCH DESIGN AND METHODS -Endothelium-dependent and C fibermediated SkBF, sensory symptoms, neurological deficits, nerve fiber morphometry, quantitative sensory and autonomic function testing, nerve conduction studies, quality of life (using the Norfolk Quality-of-Life Questionnaire for Diabetic Neuropathy [QOL-DN]), and adverse events were evaluated for 20 placebo-and 20 ruboxistaurin-treated (32 mg/day) DPN patients (aged Ն18 years; with type 1 or type 2 diabetes and A1C Յ11%) during a randomized, doublemasked, single-site, 6-month study.RESULTS -Endothelium-dependent (ϩ78.2%, P Ͻ 0.03) and C fiber-mediated (ϩ56.4%, P Ͻ 0.03) SkBF at the distal calf increased from baseline to end point. Significant improvements from baseline within the ruboxistaurin group were also observed for the Neuropathy Total Symptom Score-6 (NTSS-6) (3 months Ϫ48.3%, P ϭ 0.01; end point Ϫ66.0%, P Ͻ 0.0006) and the Norfolk QOL-DN symptom subscore and total score (end point Ϫ41.2%, P ϭ 0.01, and Ϫ41.0, P ϭ 0.04, respectively). Between-group differences in baseline-to-end point change were observed for NTSS-6 total score (placebo Ϫ13.1%; ruboxistaurin Ϫ66.0%, P Ͻ 0.03) and the Norfolk QOL-DN symptom subscore (placebo Ϫ4.0%; ruboxistaurin Ϫ41.2%, P ϭ 0.041). No significant ruboxistaurin effects were demonstrated for the remaining efficacy measures. Adverse events were consistent with those observed in previous ruboxistaurin studies.CONCLUSIONS -In this cohort of DPN patients, ruboxistaurin enhanced SkBF at the distal calf, reduced sensory symptoms (NTSS-6), improved measures of Norfolk QOL-DN, and was well tolerated. Diabetes Care 30:896 -902, 2007

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Change in cutaneous perfusion following 10 weeks of aerobic training in Type 2 diabetes

Cited by 40 publications

References 41 publications

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

Assessment of Human Skin Microcirculation and Its Endothelial Function Using Laser Doppler Flowmetry

A 6-Month, Randomized, Double-Masked, Placebo-Controlled Study Evaluating the Effects of the Protein Kinase C-β Inhibitor Ruboxistaurin on Skin Microvascular Blood Flow and Other Measures of Diabetic Peripheral Neuropathy

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