Change in Ischemia-Modified Albumin and Its Clinical Significance During Exercise Stress Testing

Lee, Donghyeon; Jeon, Hui-Kyung; Park, Hun‐Jun; Shin, Woo-Seung; Lee, Seungwon; Youn, Ho-Joong; Kim, Chul-Min; Lee, Hae Kyung

doi:10.1253/circj.cj-09-0581

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…The test is based on the decreased ability of albumin to bind cobalt due to the structural change of NH 2 which develops in the ischemic environment. It is important to emphasise that the decreased ability of albumins to bind cobalt occurs in hypoxia, acidosis, sodium and calcium pump malfunctions, and tissue damage caused by free radicals [7, 8]. It has been shown that the concentration of IMA increases within a couple of minutes from the onset of ischemia, remains elevated until 6 to 12 hours, and returns to its normal range after 24 hours [9].…”

Section: Discussionmentioning

confidence: 99%

Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

et al. 2013

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Purpose. To evaluate the predictive effect of IMA in incarcerated hernias. Methods. Three groups (n = 7) of rats were operated. Group I aimed to mimic incarceration, group II aimed the strangulation, and group III was the sham group. IMA and LDH measurements were made. Results. IMA levels were significantly higher in strangulation mimicking group and IMA levels were normal at postoperative 6th hour in incarceration mimicking group. LDH levels were significantly higher in both incarceration and strangulation mimicking groups. Conclusion. IMA seems to be an effective marker in incarcerated hernias to predict necrosis. But we need further studies to generalise this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

et al. 2013

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“…The most common condition connected with such disturbances is tissue ischemia caused mainly by myocardial infarction and ischemic heart disease. Moreover, increased levels of IMA are observed in diabetes (especially when complicated with hypertension), atherosclerosis and intense physical exertion [18–20]. …”

Section: Introductionmentioning

confidence: 99%

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Żurawska-Płaksej

Grzebyk

Marciniak

et al. 2014

J Endocrinol Invest

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BackgroundMetabolic syndrome (MetS) is a complex metabolic disease connected especially with lipid and carbohydrate disturbances. It is postulated that oxidative stress (OS) is linked to metabolic syndrome, constituting a novel component of its pathogenesis.AimWe aimed to examine the plasma level of oxidatively modified proteins––advanced oxidation protein products (AOPP) and ischemia modified albumin (IMA)––as well as thiol (SH) groups and evaluate their connection with metabolic agents in relation to MetS prevalence.Subjects and methodsThe levels of AOPP, IMA and SH groups were measured spectrophotometrically in 106 patients with MetS risk factors and in 32 control subjects.ResultsThe levels of examined parameters differed significantly between patients with MetS risk factors and the control group. AOPP significantly correlated with glucose (r = 0.30, p = 0.008), HDL-Ch (r = −0.34, p = 0.005), TG (r = 0.48, p < 0.001) and fibrinogen (r = 0.37, p < 0.001). The levels of AOPP and IMA increased progressively with the number of MetS risk factors, being the most significant for AOPP. The highest values of AOPP were associated with the presence of at least three risk factors. Only AOPP were an independent determinant for MetS occurrence in the studied population (OR = 2.72, p = 0.04). Mutual dependence between metabolic, oxidative stress and inflammatory parameters was revealed.ConclusionsOxidative modifications of proteins are increased in MetS and accumulation of MetS risk factors enhances manifestation of OS. AOPP is the most appropriate parameter for determination of OS, with potential diagnostic value in MetS patients.

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“…Another old score system, Duke treadmill score, seemed to well balance the ST-segment depression and chest pain [3]. However, other clinical informations, like age, lipid level or heart rate are not included.…”

Section: The Value Of Ett In Diagnosis Of Cad In Male and Female Patimentioning

confidence: 99%

“…The position of ETT is going down these years by its high false positive and negative rates [1]. People are looking for more parameters that ETT can provide to increase its accuracy rate, like ST/HR slope, Duke treadmill score, QT dispersion and so on [2][3][4]. ST-segment depression and chest pain as the classic criteria for CAD diagnosis are well known and accepted.…”

Section: Introductionmentioning

confidence: 99%

The value of exercise treadmill test in evaluation of coronary artery disease

Mao¹,

Li²,

Zhong³

et al. 2012

RusOMJ

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Abstract:Objective: To evaluate the value of Exercise treadmill test (ETT) in the diagnosis of coronary artery disease (CAD). Methods: Here we reviewed 142 (men, 104, mean age, 52.7±8.6) consecutive patients admitted to the 4th Clinical Hospital of Harbin Medical University for suspicion of CAD and they underwent ETT before coronary angiography (CAG). Patients were divided into four groups to see the sensitivity of different ETT criteria: group I: ETT negative, group II: ETT positive (ST-segment depression ≥0.1mv for more than 2 minutes), group III: ETT positive (exercise induced chest pain), group IV: ETT positive (exercise induced chest pain and ST-segment depression). The severity of coronary artery stenosis was assessed by CAG, only those with >50% of narrowing in at least one of the three major arteries or their first-order branches was considered CAG positive. Results: The false negative rate was 30.6% and the accuracy rate was 69.4% in group I. In group II, III and IV, the accuracy rates and false positive rates were 53.7% and 46.3%, 78.6% and 21.4%, 86.7% and 13.3%, respectively, (p<0.05). Furthermore, we analyzed the data of male patients in each group and the accuracy rates were 67.9%, 60.7%, 76.9%, 100%, respectively, (p<0.05). Multivariate logistic regression results showed that ST-segment depression together with exercise induced chest pain were the most related factors in CAD diagnosis. Conclusion: ST-segment depression and exercise induced chest pain are the strongest factors in CAD diagnosis. Chest pain combined with ST-segment depression had a much higher accuracy rate than ST-segment depression alone.

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Change in Ischemia-Modified Albumin and Its Clinical Significance During Exercise Stress Testing

Cited by 12 publications

References 24 publications

Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

The value of exercise treadmill test in evaluation of coronary artery disease

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